Q9Y6K1 | DNM3A_HUMAN | DNA (cytosine-5)-methyltransferase 3A (DNMT3A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00145 | DNA_methylase - C-5 cytosine-specific DNA methylase | 634~766 | |
| PF00855 | PWWP - PWWP domain | 293~374 | |
| PF17980 | ADD_DNMT3 - DNMT3, cysteine rich ADD domain, GATA1-like zinc finger | 475~530 | |
| PF21255 | DNMT3_ADD_GATA1-like - DNMT3, ADD PHD zinc finger | 537~586 | |
| PF22855 | DNM3A_N - DNA (cytosine-5-)-methyltransferase, N-terminal | 4~284 |
3D structures mapped by conservation among orthologs
[ Domain: "SH3" // PWWP ]
[ Domain: "S-adenosyl-L-methionine-dependent methyltransferases" // DNA_methylase_1 ]
[ Domain: "FYVE/PHD zinc finger" // ADDz_Dnmt3l ]
[ Domain: "FYVE/PHD zinc finger" // ADDz_Dnmt3b ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5285340 |  |
IC50 | = | 800.0 | nM | 481.56 | O=C(Nc1ccc(Nc2ccnc3ccccc23)cc1)c1cccc(Nc2ccnc3ccccc23)c1 | Homo sapiens | CHEMBL5241917 | single protein format |
| CHEMBL2336409 |  |
IC50 | = | 900.0 | nM | 461.53 | Cc1cc(Nc2ccc(NC(=O)c3ccc(Nc4ccnc5ccccc45)cc3)cc2)nc(N)n1 | Homo sapiens | CHEMBL4625181 | single protein format |
| CHEMBL5276042 |  |
IC50 | = | 900.0 | nM | 431.5 | O=C(Nc1ccc(Nc2ccnc3ccccc23)cc1)c1ccc(Nc2ccncc2)cc1 | Homo sapiens | CHEMBL5241908 | single protein format |
| CHEMBL4878570 |  |
IC50 | = | 930.0 | nM | 590.72 | O=C(NO)C1CCN(CC(O)COC(Cn2c3ccccc3c3ccccc32)Cn2c3ccccc3c3ccccc32)CC1 | Homo sapiens | CHEMBL4819314 | single protein format |