Q9Y6F1 | PARP3_HUMAN | Protein mono-ADP-ribosyltransferase PARP3 (PARP3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00644 | PARP - Poly(ADP-ribose) polymerase catalytic domain | 335~532 | |
| PF02877 | PARP_reg - Poly(ADP-ribose) polymerase, regulatory domain | 183~319 | |
| PF05406 | WGR - WGR domain | 66~143 |
3D structures mapped by conservation among orthologs
[ Domain: "Domain of poly(ADP-ribose) polymerase" // PARP_reg ]
[ Domain: "WGR domain" // WGR ]
[ Domain: "ADP-ribosylation" // PARP ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5402698 |  |
IC50 | = | 1.1 | nM | 549.36 | O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCn2c(nnc2-c2ccc(Br)o2)C1 | Homo sapiens | CHEMBL5366429 | single protein format |
| CHEMBL3970252 |  |
IC50 | = | 18.0 | nM | 311.35 | CC(C)(N)C(=O)N1CC2=NNC(=O)c3cccc4[nH]c(c2c34)C1 | Homo sapiens | CHEMBL3887991 | single protein format |
| CHEMBL3740104 |  |
IC50 | = | 46.0 | nM | 450.5 | N#Cc1cccnc1N1CCN(C(=O)c2cccc(Cc3n[nH]c(=O)c4ccccc34)c2)CC1 | Homo sapiens | CHEMBL3743827 | single protein format |
| CHEMBL521686 |  |
IC50 | = | 46.0 | nM | 434.47 | O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCN(C(=O)C2CC2)CC1 | Homo sapiens | CHEMBL3743827 | single protein format |
| CHEMBL595018 |  |
IC50 | = | 50.0 | nM | 307.35 | O=C1NCC2c3c(cccc31)CCN2C(=O)Cc1cccnc1 | Homo sapiens | CHEMBL1074655 | single protein format |
| CHEMBL5403305 |  |
IC50 | = | 51.0 | nM | 488.5 | CCC(CC)N1CCN(C(=O)c2cc(Cn3c(=O)[n-]c(=O)c4ccccc43)ccc2F)CC1=O.[Na+] | Homo sapiens | CHEMBL5373891 | cell-based format |
| CHEMBL3764816 |  |
IC50 | = | 62.8 | nM | 380.36 | Cn1ncnc1[C@@H]1c2n[nH]c(=O)c3cc(F)cc(c23)N[C@H]1c1ccc(F)cc1 | Homo sapiens | CHEMBL3995362 | assay format |
| CHEMBL3907010 |  |
IC50 | = | 66.9 | nM | 486.43 | CC1CN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)Cc2nnc(C(F)(F)F)n21 | Homo sapiens | CHEMBL3887959 | single protein format |
| CHEMBL609002 |  |
IC50 | = | 70.0 | nM | 322.37 | O=C1NCC2c3c(cccc31)CCN2C(=O)CCc1cnccn1 | Homo sapiens | CHEMBL1074655 | single protein format |
| CHEMBL5199558 |  |
IC50 | = | 110.0 | nM | 282.34 | Cc1ccc2c(=O)[nH]c(-c3ccc(C(C)(C)O)cc3)cn12 | Homo sapiens | CHEMBL5228291 | cell-based format |
| CHEMBL3911687 |  |
IC50 | = | 136.0 | nM | 271.3 | CC1(C)CC2=NNC(=O)c3cc(F)cc4[nH]c(c2c34)C1 | Homo sapiens | CHEMBL3887991 | single protein format |
| CHEMBL3922789 |  |
IC50 | = | 180.0 | nM | 294.31 | O=C1NN=C2CN(C(=O)C3CC3)Cc3[nH]c4cccc1c4c32 | Homo sapiens | CHEMBL3887991 | single protein format |
| CHEMBL4112930 |  |
IC50 | = | 185.0 | nM | 298.32 | C[C@]12CCCN1CC1=NNC(=O)c3cc(F)cc4[nH]c2c1c34 | Homo sapiens | CHEMBL3887991 | single protein format |
| CHEMBL3891329 |  |
IC50 | = | 199.0 | nM | 225.25 | O=C1NN=C2CCCc3[nH]c4cccc1c4c32 | Homo sapiens | CHEMBL3887991 | single protein format |
| CHEMBL1094636 |  |
IC50 | = | 296.0 | nM | 320.4 | NC(=O)c1cccc2cn(-c3ccc([C@@H]4CCCNC4)cc3)nc12 | Homo sapiens | CHEMBL3995362 | assay format |
| CHEMBL1173055 |  |
IC50 | = | 512.0 | nM | 323.37 | CNCc1ccc(-c2[nH]c3cc(F)cc4c3c2CCNC4=O)cc1 | Homo sapiens | CHEMBL3995362 | assay format |
| CHEMBL3978989 |  |
IC50 | = | 660.0 | nM | 310.36 | CC(C)(C)C(=O)N1CC2=NNC(=O)c3cccc4[nH]c(c2c34)C1 | Homo sapiens | CHEMBL3887991 | single protein format |
| CHEMBL3907535 |  |
IC50 | = | 760.0 | nM | 268.32 | CC(C)N1CC2=NNC(=O)c3cccc4[nH]c(c2c34)C1 | Homo sapiens | CHEMBL3887991 | single protein format |
| CHEMBL1086580 |  |
IC50 | = | 839.0 | nM | 312.32 | Oc1nc(-c2ccc(C(F)(F)F)cc2)nc2c1CSCC2 | Homo sapiens | CHEMBL3995362 | assay format |
| CHEMBL3092537 |  |
IC50 | = | 900.0 | nM | 321.38 | C[C@H](NC(=O)CCc1nc2ccccc2c(=O)[nH]1)c1ccccc1 | Homo sapiens | CHEMBL3096299 | single protein format |