Q9Y6A2 | CP46A_HUMAN | Cholesterol 24-hydroxylase (CYP46A1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00067 | p450 - Cytochrome P450 | 34~469 |
3D structures mapped by conservation among orthologs
[ Domain: "Cytochrome P450" // p450 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5279173 |  |
IC50 | = | 1.0 | nM | 374.44 | O=C(c1cccnc1-c1ccncn1)N1CCC(O)(Cc2ccccc2)CC1 | Homo sapiens | CHEMBL5237300 | assay format |
| CHEMBL5288661 |  |
IC50 | = | 2.4 | nM | 406.91 | O=C(c1cc(Cl)ccc1-c1ccncc1)N1CCC(O)(Cc2ccccc2)CC1 | Homo sapiens | CHEMBL5237300 | assay format |
| CHEMBL5276973 |  |
IC50 | = | 2.7 | nM | 386.5 | Cc1ccc(-c2ccncc2)c(C(=O)N2CCC(O)(Cc3ccccc3)CC2)c1 | Homo sapiens | CHEMBL5237300 | assay format |
| CHEMBL5282804 |  |
IC50 | = | 4.3 | nM | 373.46 | O=C(c1ccccc1-c1ccncn1)N1CCC(O)(Cc2ccccc2)CC1 | Homo sapiens | CHEMBL5237300 | assay format |
| CHEMBL5271033 |  |
IC50 | = | 4.4 | nM | 386.5 | Cc1ccc(C(=O)N2CCC(O)(Cc3ccccc3)CC2)c(-c2ccncc2)c1 | Homo sapiens | CHEMBL5237300 | assay format |
| CHEMBL5269674 |  |
IC50 | = | 4.7 | nM | 402.49 | COc1ccc(-c2ccncc2)c(C(=O)N2CCC(O)(Cc3ccccc3)CC2)c1 | Homo sapiens | CHEMBL5237300 | assay format |
| CHEMBL5289771 |  |
IC50 | = | 4.9 | nM | 400.52 | Cc1ccc(-c2ccncc2C)c(C(=O)N2CCC(O)(Cc3ccccc3)CC2)c1 | Homo sapiens | CHEMBL5237300 | assay format |
| CHEMBL5284673 |  |
IC50 | = | 6.1 | nM | 390.46 | O=C(c1cc(F)ccc1-c1ccncc1)N1CCC(O)(Cc2ccccc2)CC1 | Homo sapiens | CHEMBL5237300 | assay format |
| CHEMBL5093928 |  |
IC50 | = | 7.3 | nM | 328.39 | CN(C)C(=O)C1CCN(c2cncnc2-c2ccc(F)cc2)CC1 | Homo sapiens | CHEMBL5042226 | cell-based format |
| CHEMBL4298172 |  |
IC50 | = | 7.4 | nM | 373.46 | O=C(c1cccnc1-c1ccncc1)N1CCC(O)(Cc2ccccc2)CC1 | Homo sapiens | CHEMBL5042226 | cell-based format |
| CHEMBL5275089 |  |
IC50 | = | 7.8 | nM | 386.5 | Cc1cccc(-c2ccncc2)c1C(=O)N1CCC(O)(Cc2ccccc2)CC1 | Homo sapiens | CHEMBL5237300 | assay format |
| CHEMBL5275183 |  |
IC50 | = | 7.9 | nM | 372.47 | O=C(c1ccccc1-c1ccncc1)N1CCC(O)(Cc2ccccc2)CC1 | Homo sapiens | CHEMBL5237300 | assay format |
| CHEMBL4594072 |  |
IC50 | = | 8.1 | nM | 321.42 | O=C(NC1CC1)C1CCN(c2cnccc2-c2ccccc2)CC1 | Homo sapiens | CHEMBL5042226 | cell-based format |
| CHEMBL4532699 |  |
IC50 | = | 8.5 | nM | 313.41 | Cc1cnn(-c2ccncc2N2CCC(C(=O)N(C)C)CC2)c1 | Homo sapiens | CHEMBL5042226 | cell-based format |
| CHEMBL4527933 |  |
IC50 | = | 9.5 | nM | 378.27 | CN(C)C(=O)C1CCN(c2cnccc2-n2cc(Br)cn2)CC1 | Homo sapiens | CHEMBL5042226 | cell-based format |
| CHEMBL5083867 |  |
IC50 | = | 12.0 | nM | 330.46 | Cc1cnc(-c2ccncc2N2CCC(C(=O)N(C)C)CC2)s1 | Homo sapiens | CHEMBL5042226 | cell-based format |
| CHEMBL4538165 |  |
IC50 | = | 12.0 | nM | 339.44 | CN(C)C(=O)C1CCN(c2cnccc2-n2cc(C3CC3)cn2)CC1 | Homo sapiens | CHEMBL5042226 | cell-based format |
| CHEMBL5076011 |  |
IC50 | = | 14.0 | nM | 324.43 | CCN(C)C(=O)C1CCN(c2cncnc2-c2ccccc2)CC1 | Homo sapiens | CHEMBL5042226 | cell-based format |
| CHEMBL5082831 |  |
IC50 | = | 16.0 | nM | 310.4 | CN(C)C(=O)C1CCN(c2cncnc2-c2ccccc2)CC1 | Homo sapiens | CHEMBL5042226 | cell-based format |
| CHEMBL5286208 |  |
IC50 | = | 16.0 | nM | 386.5 | Cc1ccc(-c2ccncc2)c(C(=O)N2CCC(Cc3ccccc3)C(O)C2)c1 | Homo sapiens | CHEMBL5237300 | assay format |