Q9Y616 | IRAK3_HUMAN | Interleukin-1 receptor-associated kinase 3 (IRAK3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 167~441 | |
| PF00531 | Death - Death domain | 27~105 |
3D structures mapped by conservation among orthologs
[ Domain: "DEATH domain" // Death ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4788568 |  |
IC50 | = | 4.0 | nM | 384.53 | CC(=O)N1CCN([C@H]2CC[C@@H](Nc3ncnc4[nH]cc(C(C)C)c34)CC2)CC1 | Homo sapiens | CHEMBL4729445 | cell-based format |
| CHEMBL4744403 |  |
IC50 | = | 6.0 | nM | 384.53 | CC(=O)N1CCN([C@H]2CC[C@@H](Nc3ncnn4ccc(C(C)C)c34)CC2)CC1 | Homo sapiens | CHEMBL4729445 | cell-based format |
| CHEMBL4094760 |  |
IC50 | = | 10.0 | nM | 385.51 | c1nc(N[C@H]2CC[C@@H](N3CCOCC3)CC2)c2c(C3CCOCC3)c[nH]c2n1 | Homo sapiens | CHEMBL4729445 | cell-based format |
| CHEMBL4064608 |  |
IC50 | = | 27.0 | nM | 385.51 | c1nc(N[C@H]2CC[C@H](N3CCOCC3)CC2)c2c(C3CCOCC3)c[nH]c2n1 | Homo sapiens | CHEMBL4729445 | cell-based format |
| CHEMBL4278882 |  |
IC50 | = | 31.0 | nM | 384.53 | CC(=O)N1CCN([C@H]2CC[C@H](Nc3ncnn4ccc(C(C)C)c34)CC2)CC1 | Homo sapiens | CHEMBL4729445 | cell-based format |
| CHEMBL4634922 |  |
IC50 | = | 760.0 | nM | 433.46 | CC(C)Nc1cc(Nc2nc3ccnn3cc2F)ncc1C(=O)NC[C@@H](F)C(C)(C)O | Homo sapiens | CHEMBL4625646 | assay format |
| CHEMBL4522930 |  |
IC50 | = | 921.0 | nM | 432.52 | CCC(F)(F)c1cc(N2CCC(S(C)(=O)=O)CC2)nc2sc(C(N)=O)c(N)c12 | Homo sapiens | CHEMBL4887161 | single protein format |