Q9Y5Y9 | SCNAA_HUMAN | Sodium channel protein type 10 subunit alpha (SCN10A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00520 | Ion_trans - Ion transport protein | 129~407 | |
| PF00520 | Ion_trans - Ion transport protein | 666~896 | |
| PF00520 | Ion_trans - Ion transport protein | 1151~1427 | |
| PF00520 | Ion_trans - Ion transport protein | 1476~1732 | |
| PF06512 | Na_trans_assoc - Sodium ion transport-associated | 904~1147 | |
| PF24609 | IQ_SCN5A_C - SCN5A-like, C-terminal IQ motif | 1844~1872 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4760292 |  |
IC50 | = | 0.3 | nM | 459.91 | Cc1nc(N2CCCC(F)(F)CC2)c(C(=O)Nc2ccnc(S(N)(=O)=O)c2)cc1Cl | Homo sapiens | CHEMBL4672963 | cell-based format |
| CHEMBL4798938 |  |
IC50 | = | 0.4 | nM | 581.37 | COc1cc(Oc2ccc(OC(F)(F)F)c(F)c2OC)c(C(=O)Nc2ccnc(C(N)=O)c2)c(F)c1C(F)(F)F | Homo sapiens | CHEMBL4672974 | cell-based format |
| CHEMBL4777598 |  |
IC50 | = | 0.5 | nM | 493.46 | Cc1nc(N2CCCC(F)(F)CC2)c(C(=O)Nc2ccnc(S(N)(=O)=O)c2)cc1C(F)(F)F | Homo sapiens | CHEMBL4672963 | cell-based format |
| CHEMBL4753280 |  |
IC50 | = | 0.8 | nM | 565.37 | COc1c(Oc2cc(C(F)(F)F)c(C)c(F)c2C(=O)Nc2ccnc(C(N)=O)c2)ccc(OC(F)(F)F)c1F | Homo sapiens | CHEMBL4672974 | cell-based format |
| CHEMBL4781110 |  |
IC50 | = | 0.9 | nM | 465.53 | NS(=O)(=O)c1cc(NC(=O)c2ccc(CC3CC3)nc2N2CCCC(F)(F)CC2)ccn1 | Homo sapiens | CHEMBL4672963 | cell-based format |
| CHEMBL4745699 |  |
IC50 | = | 1.0 | nM | 465.53 | NS(=O)(=O)c1cc(NC(=O)c2cc(CC3CC3)cnc2N2CCCC(F)(F)CC2)ccn1 | Homo sapiens | CHEMBL4672963 | cell-based format |
| CHEMBL1277958 |  |
IC50 | = | 1.0 | nM | 333.39 | CCOc1ccc(-c2cncc(C(=O)Nc3cccc(C)c3)n2)cc1 | Homo sapiens | CHEMBL1286452 | cell-based format |
| CHEMBL4744908 |  |
IC50 | = | 1.3 | nM | 547.82 | COc1c(Cl)cc(Oc2ccc(OC(F)(F)F)c(F)c2OC)c(C(=O)Nc2ccnc(C(N)=O)c2)c1F | Homo sapiens | CHEMBL4672974 | cell-based format |
| CHEMBL4750365 |  |
IC50 | = | 1.4 | nM | 531.82 | COc1c(Oc2cc(Cl)c(C)c(F)c2C(=O)Nc2ccnc(C(N)=O)c2)ccc(OC(F)(F)F)c1F | Homo sapiens | CHEMBL4672974 | cell-based format |
| CHEMBL4787299 |  |
IC50 | = | 1.6 | nM | 581.37 | COc1c(Oc2cc(C(F)(F)F)c(OC)c(F)c2C(=O)Nc2ccnc(C(N)=O)c2)ccc(OC(F)(F)F)c1F | Homo sapiens | CHEMBL4672974 | cell-based format |
| CHEMBL4764433 |  |
IC50 | = | 1.6 | nM | 439.49 | Cc1cc(C(=O)Nc2ccnc(S(N)(=O)=O)c2)c(N2CCCC(F)(F)CC2)nc1C | Homo sapiens | CHEMBL4672963 | cell-based format |
| CHEMBL4756380 |  |
IC50 | = | 1.7 | nM | 547.82 | COc1cc(Oc2ccc(OC(F)(F)F)c(F)c2OC)c(C(=O)Nc2ccnc(C(N)=O)c2)c(F)c1Cl | Homo sapiens | CHEMBL4672974 | cell-based format |
| CHEMBL4782190 |  |
IC50 | = | 1.8 | nM | 563.38 | COc1cc(OC(F)(F)F)ccc1Oc1cc(OC)c(C(F)(F)F)c(F)c1C(=O)Nc1ccnc(C(N)=O)c1 | Homo sapiens | CHEMBL4672974 | cell-based format |
| CHEMBL1269882 |  |
IC50 | = | 2.0 | nM | 336.82 | Cc1ccccc1CNC(=O)c1cncc(-c2ccc(Cl)cc2)c1 | Homo sapiens | CHEMBL1272888 | single protein format |
| CHEMBL4483603 |  |
IC50 | = | 2.0 | nM | 245.37 | CCC[C@H](N)c1nc2cc(C(C)(C)C)ccc2[nH]1 | Homo sapiens | CHEMBL4331778 | cell-based format |
| CHEMBL4761578 |  |
IC50 | = | 2.0 | nM | 594.26 | COc1cc(OC(F)(F)F)ccc1Oc1ccc(C(F)(F)F)c(Br)c1C(=O)Nc1ccnc(C(N)=O)c1 | Homo sapiens | CHEMBL4672974 | cell-based format |
| CHEMBL4785523 |  |
IC50 | = | 2.0 | nM | 549.81 | COc1cc(OC(F)(F)F)ccc1Oc1ccc(C(F)(F)F)c(Cl)c1C(=O)Nc1ccnc(C(N)=O)c1 | Homo sapiens | CHEMBL4672974 | cell-based format |
| CHEMBL1270797 |  |
IC50 | = | 2.0 | nM | 375.35 | Cc1cc(C)cc(NC(=O)c2ccc(-c3ccc(OC(F)(F)F)cc3)o2)c1 | Homo sapiens | CHEMBL1272888 | single protein format |
| CHEMBL1277959 |  |
IC50 | = | 2.0 | nM | 347.42 | CCOc1ccc(-c2cncc(C(=O)NCc3ccccc3C)n2)cc1 | Homo sapiens | CHEMBL1286452 | cell-based format |
| CHEMBL1277877 |  |
IC50 | = | 2.0 | nM | 347.42 | CCOc1ccc(-c2cncc(C(=O)Nc3cc(C)cc(C)c3)n2)cc1 | Homo sapiens | CHEMBL1286452 | cell-based format |