Q9Y5Y6 | ST14_HUMAN | Suppressor of tumorigenicity 14 protein (ST14)

Pfam Domain Table

AccessionDomainRangeColor
PF00057Ldl_recept_a - Low-density lipoprotein receptor domain class A453~486
PF00057Ldl_recept_a - Low-density lipoprotein receptor domain class A488~523
PF00057Ldl_recept_a - Low-density lipoprotein receptor domain class A525~559
PF00057Ldl_recept_a - Low-density lipoprotein receptor domain class A566~602
PF00089Trypsin - Trypsin615~849
PF00431CUB - CUB domain227~331
PF00431CUB - CUB domain340~444
PF01390SEA - SEA domain89~163

3D structures mapped by conservation among orthologs

[ Domain: "FMN-binding split barrel 2" // Trypsin_1 ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL1580091 IC50 = 420.0 nM 329.81 CSc1nc(-c2ccc(Cl)cc2)nn1C(=O)c1ccccc1 Homo sapiens CHEMBL2412647 single protein format
CHEMBL1413622 IC50 = 570.0 nM 279.3 Cc1ccc(C(=O)n2nc(-c3cccnc3)nc2N)cc1 Homo sapiens CHEMBL2412647 single protein format
CHEMBL273264 Ki = 0.02 nM 347.38 N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1 Homo sapiens CHEMBL3389935 single protein format
CHEMBL3655686 Ki = 0.069 nM 553.73 N=C(N)c1cccc(CC(NS(=O)(=O)c2cccc(C3CCC(N)=NC3)c2)C(=O)N2CCC(CCN)CC2)c1 Homo sapiens CHEMBL3705096 single protein format
CHEMBL469090 Ki = 0.08 nM 553.73 N=C(N)c1cccc(C[C@H](NS(=O)(=O)c2cccc(C3CCC(N)=NC3)c2)C(=O)N2CCC(CCN)CC2)c1 Homo sapiens CHEMBL1010203 single protein format
CHEMBL3289302 Ki = 0.08 nM 553.73 N=C(N)c1cccc(C[C@@H](NS(=O)(=O)c2cccc(C3CCC(N)=NC3)c2)C(=O)N2CCC(CCN)CC2)c1 Homo sapiens CHEMBL3294545 single protein format
CHEMBL2089123 Ki = 0.088 nM 490.59 C[C@H](NC(=O)[C@@H](N)CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)c1nc2ccccc2s1 Homo sapiens CHEMBL2090833 cell-based format
CHEMBL3352840 Ki = 0.092 nM 577.67 C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)c1nc2ccccc2s1 Homo sapiens CHEMBL3378881 single protein format
CHEMBL468270 Ki = 1.0 nM 528.72 N=C(N)c1cccc(C[C@H](NS(=O)(=O)c2cccc(CCCCN)c2)C(=O)N2CCC(CCN)CC2)c1 Homo sapiens CHEMBL1010203 single protein format
CHEMBL3219087 Ki = 1.0 nM 593.75 COc1ccc(-c2cccc(S(=O)(=O)N[C@@H](Cc3cccc(C(=N)N)c3)C(=O)N3CCC(CCN)CC3)c2)c(OC)c1 Homo sapiens CHEMBL3225088 single protein format
CHEMBL3289038 Ki = 1.0 nM 487.56 N=C(N)c1ccc(Oc2cc(Oc3ccc(C(=N)N)cc3)cc(C(=O)O[C@H]3CC[C@H](N)CC3)c2)cc1 Homo sapiens CHEMBL3294545 single protein format
CHEMBL2089124 Ki = 1.4 nM 362.46 C[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)c1nc2ccccc2s1 Homo sapiens CHEMBL2090833 cell-based format
CHEMBL3951346 Ki = 1.4 nM 404.5 CC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)c1nc2ccccc2s1 Homo sapiens CHEMBL3888636 single protein format
CHEMBL379068 Ki = 1.5 nM 599.76 N=C(N)c1cccc(C[C@H](NS(=O)(=O)c2cccc(NC(=O)CCN)c2)C(=O)N2CCC(CCCN=C(N)N)CC2)c1 Homo sapiens CHEMBL868541 single protein format
CHEMBL461016 Ki = 1.6 nM 549.7 N=C(N)c1cccc(C[C@H](NS(=O)(=O)c2cccc(-c3ccc(N)nc3)c2)C(=O)N2CCC(CCN)CC2)c1 Homo sapiens CHEMBL1010203 single protein format
CHEMBL378657 Ki = 1.8 nM 585.74 N=C(N)NCCC1CCN(C(=O)[C@H](Cc2cccc(C(=N)N)c2)NS(=O)(=O)c2cccc(NC(=O)CCN)c2)CC1 Homo sapiens CHEMBL868541 single protein format
CHEMBL460810 Ki = 2.5 nM 561.75 CCc1ccc(-c2cccc(S(=O)(=O)NC(Cc3cccc(C(=N)N)c3)C(=O)N3CCC(CCN)CC3)c2)cc1 Homo sapiens CHEMBL1010203 single protein format
CHEMBL3289034 Ki = 3.0 nM 486.58 N=C(N)c1ccc(Oc2cc(NC(=O)[C@H]3CC[C@H](N)CC3)cc(Oc3ccc(C(=N)N)cc3)c2)cc1 Homo sapiens CHEMBL3294545 single protein format
CHEMBL3289301 Ki = 3.0 nM 514.63 N=C(N)c1cccc(COc2cc(OCc3cccc(C(=N)N)c3)cc(C(=O)N[C@H]3CC[C@H](N)CC3)c2)c1 Homo sapiens CHEMBL3294545 single protein format
CHEMBL461870 Ki = 3.0 nM 555.71 N=C(N)c1cccc(C[C@H](NS(=O)(=O)c2cccc(NC(=O)C3CNC3)c2)C(=O)N2CCC(CCN)CC2)c1 Homo sapiens CHEMBL1010203 single protein format