Q9Y5X5 | NPFF2_HUMAN | Neuropeptide FF receptor 2 (NPFFR2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 164~435 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4779743 |  |
Ki | = | 1.42 | nM | 520.62 | COc1cc2c(c(OC)c1OC)-c1c(cc(C)c(C)c1OC)[C@@H](C(=O)Oc1ccccc1)[C@@](C)(O)[C@@H](C)C2 | Homo sapiens | CHEMBL4772279 | cell-based format |
| CHEMBL4800299 |  |
Ki | = | 2.17 | nM | 518.61 | COc1cc2c(c(OC)c1OC)-c1c(cc3c(c1OC)CC3)[C@@H](C(=O)Oc1ccccc1)[C@@](C)(O)[C@@H](C)C2 | Homo sapiens | CHEMBL4772279 | cell-based format |
| CHEMBL2208338 |  |
Ki | = | 4.0 | nM | 500.6 | N=C(N)NCCC[C@@H](NC(=O)c1ccccc1-c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | Homo sapiens | CHEMBL2215248 | cell-based format |
| CHEMBL2208319 |  |
Ki | = | 4.0 | nM | 514.63 | N=C(N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | Homo sapiens | CHEMBL2215248 | cell-based format |
| CHEMBL262202 |  |
Ki | = | 6.6 | nM | 598.77 | CSCC[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | Homo sapiens | CHEMBL4772223 | cell-based format |
| CHEMBL2208322 |  |
Ki | = | 9.0 | nM | 500.6 | N=C(N)NCCC[C@@H](NC(=O)c1cccc(-c2ccccc2)c1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | Homo sapiens | CHEMBL2215248 | cell-based format |
| CHEMBL2208340 |  |
Ki | = | 22.0 | nM | 424.51 | N=C(N)NCCC[C@@H](NC(=O)c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | Homo sapiens | CHEMBL2215248 | cell-based format |
| CHEMBL326770 |  |
Ki | = | 25.0 | nM | 545.65 | NC(=O)CC[C@H](NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | Homo sapiens | CHEMBL4772216 | cell-based format |
| CHEMBL3361433 |  |
Ki | = | 30.0 | nM | 443.6 | N=C(N)NCC(=O)NCC1(Cc2cccc3ccccc23)CCN(Cc2ccccc2)CC1 | Homo sapiens | CHEMBL3387186 | cell-based format |
| CHEMBL4793841 |  |
Ki | = | 37.0 | nM | 242.11 | NC1=NC=C(c2ccc(Cl)c(Cl)c2)CN1 | Homo sapiens | CHEMBL4772289 | cell membrane format |
| CHEMBL1672380 |  |
Ki | = | 43.0 | nM | 482.63 | N=C(N)NCCC[C@H](NC(=O)C12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | Homo sapiens | CHEMBL2215248 | cell-based format |
| CHEMBL2208312 |  |
Ki | = | 47.0 | nM | 475.55 | N=C(N)NCCC[C@H](NC(=O)c1ccc2ccccc2n1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | Homo sapiens | CHEMBL2215248 | cell-based format |
| CHEMBL3360829 |  |
Ki | = | 75.0 | nM | 481.64 | CC(=N)NCCC[C@H](NC(=O)C12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | Homo sapiens | CHEMBL3387181 | cell-based format |
| CHEMBL3361434 |  |
Ki | = | 82.0 | nM | 462.43 | N=C(N)NCC(=O)NCC1(Cc2ccc(Cl)c(Cl)c2)CCN(Cc2ccccc2)CC1 | Homo sapiens | CHEMBL3387186 | cell-based format |
| CHEMBL332347 |  |
Ki | = | 84.0 | nM | 473.58 | NC(N)=NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 | Homo sapiens | CHEMBL3750358 | cell-based format |
| CHEMBL3361423 |  |
Ki | = | 84.0 | nM | 393.54 | N=C(N)NCC(=O)NCC1(Cc2ccccc2)CCN(Cc2ccccc2)CC1 | Homo sapiens | CHEMBL3387186 | cell-based format |
| CHEMBL4777535 |  |
Ki | = | 91.0 | nM | 200.25 | Cc1cc(NC(=N)N)nc2ccccc12 | Homo sapiens | CHEMBL4772261 | single protein format |
| CHEMBL2208339 |  |
Ki | = | 92.0 | nM | 424.51 | N=C(N)NCCC[C@H](NC(=O)c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | Homo sapiens | CHEMBL2215248 | cell-based format |
| CHEMBL2208325 |  |
Ki | = | 94.0 | nM | 500.6 | N=C(N)NCCC[C@@H](NC(=O)c1ccc(-c2ccccc2)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | Homo sapiens | CHEMBL2215248 | cell-based format |
| CHEMBL2208303 |  |
Ki | = | 117.0 | nM | 450.54 | N=C(N)NCCC[C@@H](NC(=O)/C=C/c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | Homo sapiens | CHEMBL2215248 | cell-based format |