Q9Y5S8 | NOX1_HUMAN | NADPH oxidase 1 (NOX1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01794 | Ferric_reduct - Ferric reductase like transmembrane component | 75~217 | |
| PF08022 | FAD_binding_8 - FAD-binding domain | 295~388 | |
| PF08030 | NAD_binding_6 - Ferric reductase NAD binding domain | 395~544 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL397686 |  |
IC50 | = | 240.0 | nM | 314.55 | [Cl-].c1ccc2c(c1)[I+]c1ccccc1-2 | Homo sapiens | CHEMBL5367006 | cell-based format |
| CHEMBL407734 |  |
IC50 | = | 250.0 | nM | 241.31 | CC(=O)c1ccc2c(c1)Nc1ccccc1S2 | Homo sapiens | CHEMBL5367028 | cell-based format |
| CHEMBL301982 |  |
IC50 | = | 410.0 | nM | 450.62 | CC1=C(O)C(=O)C=C2C1=CC=C1[C@@]2(C)CC[C@@]2(C)[C@@H]3C[C@](C)(C(=O)O)CC[C@]3(C)CC[C@]12C | Homo sapiens | CHEMBL5367006 | cell-based format |
| CHEMBL51085 |  |
IC50 | = | 500.0 | nM | 274.18 | O=c1c2ccccc2[se]n1-c1ccccc1 | Homo sapiens | CHEMBL5367011 | cell-based format |
| CHEMBL4210329 |  |
IC50 | = | 500.0 | nM | 360.4 | c1ccc(Cn2nnc3c(Sc4nc5ccccc5o4)ncnc32)cc1 | Homo sapiens | CHEMBL5367014 | cell-based format |
| CHEMBL4303187 |  |
Ki | = | 140.0 | nM | 394.86 | CN(C)c1cccc(-c2c3c(=O)n(-c4ccccc4Cl)[nH]c3cc(=O)n2C)c1 | Homo sapiens | CHEMBL5367025 | single protein format |
| CHEMBL1276946 |  |
Ki | = | 165.0 | nM | 366.81 | Cc1c2c(=O)n(-c3ccccc3Cl)[nH]c2cc(=O)n1Cc1ccccn1 | Homo sapiens | CHEMBL1286988 | cell-based format |
| CHEMBL3827985 |  |
Ki | = | 350.0 | nM | 371.89 | CN1C(=S)N(c2cccc(Cl)c2)C(=O)/C1=C/c1ccc(N(C)C)cc1 | Homo sapiens | CHEMBL3829980 | assay format |