Q9Y5K2 | KLK4_HUMAN | Kallikrein-4 (KLK4)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00089 | Trypsin - Trypsin | 31~247 |
3D structures mapped by conservation among orthologs
[ Domain: "FMN-binding split barrel 2" // Trypsin_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1184949 |  |
IC50 | = | 3.4 | nM | 530.52 | N=C(N)Nc1ccc(C(NC(=O)OCc2ccccc2)P(=O)(Oc2ccccc2)Oc2ccccc2)cc1 | Homo sapiens | CHEMBL3772516 | assay format |
| CHEMBL239535 |  |
IC50 | = | 12.0 | nM | 544.55 | N=C(N)Nc1ccc(CC(NC(=O)OCc2ccccc2)P(=O)(Oc2ccccc2)Oc2ccccc2)cc1 | Homo sapiens | CHEMBL3772516 | assay format |
| CHEMBL238913 |  |
IC50 | = | 15.0 | nM | 543.56 | N=C(N)c1ccc(CCC(NC(=O)OCc2ccccc2)P(=O)(Oc2ccccc2)Oc2ccccc2)cc1 | Homo sapiens | CHEMBL3772516 | assay format |
| CHEMBL239331 |  |
IC50 | = | 40.0 | nM | 496.5 | N=C(N)NCCCC(NC(=O)OCc1ccccc1)P(=O)(Oc1ccccc1)Oc1ccccc1 | Homo sapiens | CHEMBL3772516 | assay format |
| CHEMBL238707 |  |
IC50 | = | 41.0 | nM | 515.51 | N=C(N)c1ccc(C(NC(=O)OCc2ccccc2)P(=O)(Oc2ccccc2)Oc2ccccc2)cc1 | Homo sapiens | CHEMBL3772516 | assay format |
| CHEMBL3770794 |  |
IC50 | = | 80.0 | nM | 395.4 | N=C(N)Nc1ccc(CCP(=O)(Oc2ccccc2)Oc2ccccc2)cc1 | Homo sapiens | CHEMBL3772516 | assay format |
| CHEMBL3771081 |  |
IC50 | = | 250.0 | nM | 381.37 | N=C(N)Nc1ccc(CP(=O)(Oc2ccccc2)Oc2ccccc2)cc1 | Homo sapiens | CHEMBL3772516 | assay format |