Q9Y572 | RIPK3_HUMAN | Receptor-interacting serine/threonine-protein kinase 3 (RIPK3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 22~280 | |
| PF12721 | RHIM - RIP homotypic interaction motif | 448~468 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4470115 |  |
IC50 | = | 0.3 | nM | 550.53 | Nc1ccc(C#Cc2c(Oc3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3F)ccnc2N)nc1 | Homo sapiens | CHEMBL4344880 | cell-based format |
| CHEMBL4439913 |  |
IC50 | = | 0.3 | nM | 365.43 | CNC(=O)c1ccc2c(c1)ncn2-c1ccc(CC(=O)OC(C)(C)C)cc1 | Homo sapiens | CHEMBL4425337 | assay format |
| CHEMBL4779280 |  |
IC50 | = | 1.3 | nM | 383.5 | CC(C)S(=O)(=O)c1ccc2nccc(Nc3ccc4scnc4c3)c2c1 | Homo sapiens | CHEMBL5210337 | single protein format |
| CHEMBL1171837 |  |
IC50 | = | 1.6 | nM | 532.57 | Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 | Homo sapiens | CHEMBL4378731 | cell-based format |
| CHEMBL4455682 |  |
IC50 | = | 2.9 | nM | 502.48 | O=C(Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)c(F)c1)c1cccn(-c2ccc(F)cc2)c1=O | Homo sapiens | CHEMBL4344883 | single protein format |
| CHEMBL4476485 |  |
IC50 | = | 8.0 | nM | 498.51 | Cc1cc(NC(=O)c2cccn(-c3ccc(F)cc3)c2=O)ccc1Oc1ccnc(NC(=O)C2CC2)c1 | Homo sapiens | CHEMBL4344883 | single protein format |
| CHEMBL4441118 |  |
IC50 | = | 8.6 | nM | 377.5 | Cc1cc(-c2cnc(N)c3c(-c4ccc5scnc5c4)csc23)n(C)n1 | Homo sapiens | CHEMBL5339918 | assay format |
| CHEMBL3823499 |  |
IC50 | = | 16.0 | nM | 398.46 | CC(C)(C)S(=O)(=O)c1ccc2nccc(Nc3n[nH]c4ccc(F)cc34)c2c1 | Homo sapiens | CHEMBL3825649 | single protein format |
| CHEMBL4552106 |  |
IC50 | = | 16.0 | nM | 472.45 | CC#Cc1c(Oc2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)ccnc1N | Homo sapiens | CHEMBL4344883 | single protein format |
| CHEMBL4438939 |  |
IC50 | = | 50.0 | nM | 451.46 | O=C(Nc1ccc(Oc2ccncc2)c2ccccc12)c1cccn(-c2ccc(F)cc2)c1=O | Homo sapiens | CHEMBL4344883 | single protein format |
| CHEMBL4476076 |  |
IC50 | = | 88.0 | nM | 512.54 | Cc1cc(NC(=O)c2cccn(-c3ccc(F)cc3)c2=O)cc(C)c1Oc1ccnc(NC(=O)C2CC2)c1 | Homo sapiens | CHEMBL4344883 | single protein format |
| CHEMBL3125890 |  |
IC50 | = | 90.0 | nM | 554.53 | N#Cc1c(Oc2ccc(F)c(NC(=O)Cc3cccc(C(F)(F)F)c3)c2)ccc2nc(NC(=O)C3CC3)sc12 | Homo sapiens | CHEMBL5339937 | single protein format |
| CHEMBL4551490 |  |
IC50 | = | 91.0 | nM | 512.54 | Cc1c(NC(=O)c2cccn(-c3ccc(F)cc3)c2=O)ccc(Oc2ccnc(NC(=O)C3CC3)c2)c1C | Homo sapiens | CHEMBL4344883 | single protein format |
| CHEMBL509101 |  |
IC50 | = | 180.0 | nM | 458.42 | O=C(Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1)c1cccn(-c2ccc(F)cc2)c1=O | Homo sapiens | CHEMBL4344883 | single protein format |
| CHEMBL4434881 |  |
IC50 | = | 180.0 | nM | 429.45 | Cc1c(NC(=O)c2cccn(-c3ccc(F)cc3)c2=O)ccc(Oc2ccncc2)c1C | Homo sapiens | CHEMBL4344883 | single protein format |
| CHEMBL4569395 |  |
IC50 | = | 200.0 | nM | 376.49 | CC(=O)O[C@@H]1CCC(C)(C)[C@H]2C[C@@H](O)C3=C[C@@H](CCC(=O)[C@@]21C)[C@H](C)C3=O | Homo sapiens | CHEMBL4378760 | cell-based format |
| CHEMBL2028663 |  |
IC50 | = | 250.0 | nM | 519.57 | CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(-c2ccnc(N)n2)s1 | Homo sapiens | CHEMBL4378747 | cell-based format |
| CHEMBL3735817 |  |
IC50 | = | 270.0 | nM | 452.59 | CN1CCN(c2ccc3nc(-c4cccc(-c5cccs5)c4)c(-c4ccncc4)n3n2)CC1 | Homo sapiens | CHEMBL3736773 | cell-based format |
| CHEMBL4434926 |  |
IC50 | = | 270.0 | nM | 376.42 | Cc1ccc(COC(=O)Nc2cc(-c3cc4c([nH]3)CCNC4=O)ccn2)cc1 | Homo sapiens | CHEMBL4344880 | cell-based format |
| CHEMBL3735315 |  |
IC50 | = | 300.0 | nM | 452.59 | CN1CCN(c2ccc3nc(-c4cccc(-c5ccsc5)c4)c(-c4ccncc4)n3n2)CC1 | Homo sapiens | CHEMBL3736773 | cell-based format |