Q9Y4P1 | ATG4B_HUMAN | Cysteine protease ATG4B (ATG4B)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF03416 | Peptidase_C54 - Peptidase C54 catalytic domain | 40~335 | |
| PF20166 | ATG4_LIR - ATG4, F-type LIR motif | 363~391 |
3D structures mapped by conservation among orthologs
[ Domain: "Cysteine proteinases" // Peptidase_C54 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4581663 |  |
IC50 | = | 15.0 | nM | 410.42 | O=C(CF)CNC(=O)[C@H](Cc1ccccc1)NC(=O)c1cccc2c(F)cccc12 | Homo sapiens | CHEMBL4480315 | cell-based format |
| CHEMBL4546760 |  |
IC50 | = | 60.0 | nM | 410.42 | O=C(CF)CNC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc(F)c2ccccc12 | Homo sapiens | CHEMBL4480315 | cell-based format |
| CHEMBL4520267 |  |
IC50 | = | 73.0 | nM | 392.43 | O=C(CF)CNC(=O)[C@H](Cc1ccccc1)NC(=O)c1cccc2ccccc12 | Homo sapiens | CHEMBL4480315 | cell-based format |
| CHEMBL4520585 |  |
IC50 | = | 130.0 | nM | 406.46 | CN(CC(=O)CF)C(=O)[C@H](Cc1ccccc1)NC(=O)c1cccc2ccccc12 | Homo sapiens | CHEMBL4480315 | cell-based format |
| CHEMBL4553669 |  |
IC50 | = | 230.0 | nM | 394.41 | O=C(CF)CNC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnnc2ccccc12 | Homo sapiens | CHEMBL4480315 | cell-based format |
| CHEMBL1496397 |  |
IC50 | = | 316.0 | nM | 466.63 | Cc1sc2nc(C3CCCCC3)nc(SCC(=O)N3CC(=O)Nc4ccccc43)c2c1C | Homo sapiens | CHEMBL3870650 | assay format |
| CHEMBL4469737 |  |
IC50 | = | 360.0 | nM | 422.46 | O=C(CF)CNC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1cccc2ccccc12 | Homo sapiens | CHEMBL4407115 | single protein format |
| CHEMBL4567870 |  |
IC50 | = | 530.0 | nM | 393.42 | O=C(CF)CNC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccnc2ccccc12 | Homo sapiens | CHEMBL4480315 | cell-based format |
| CHEMBL4560825 |  |
IC50 | = | 610.0 | nM | 357.19 | O=C(NCc1ccc(Br)cc1)Nc1ncc([N+](=O)[O-])s1 | Homo sapiens | CHEMBL4482757 | single protein format |
| CHEMBL303579 |  |
IC50 | = | 630.0 | nM | 331.8 | O=C(N[C@@H](Cc1ccccc1)C(=O)CCl)OCc1ccccc1 | Homo sapiens | CHEMBL3870651 | single protein format |
| CHEMBL4534968 |  |
IC50 | = | 640.0 | nM | 329.34 | O=C(NCc1cnc2ccccc2c1)Nc1ncc([N+](=O)[O-])s1 | Homo sapiens | CHEMBL4482757 | single protein format |
| CHEMBL4578571 |  |
IC50 | = | 720.0 | nM | 372.4 | COc1cccc(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(=O)CF)c1 | Homo sapiens | CHEMBL4480313 | single protein format |
| CHEMBL4483776 |  |
IC50 | = | 730.0 | nM | 312.74 | O=C(NCc1cccc(Cl)c1)Nc1ncc([N+](=O)[O-])s1 | Homo sapiens | CHEMBL4482757 | single protein format |
| CHEMBL4575072 |  |
IC50 | = | 850.0 | nM | 279.28 | O=C(NCc1cccnc1)Nc1ncc([N+](=O)[O-])s1 | Homo sapiens | CHEMBL4482757 | single protein format |
| CHEMBL4592322 |  |
IC50 | = | 880.0 | nM | 346.29 | O=C(NCc1ccc(C(F)(F)F)cc1)Nc1ncc([N+](=O)[O-])s1 | Homo sapiens | CHEMBL4482757 | single protein format |
| CHEMBL4574173 |  |
IC50 | = | 920.0 | nM | 356.4 | O=C(CF)CNC(=O)[C@H](Cc1ccccc1)NC(=O)Cc1ccccc1 | Homo sapiens | CHEMBL4480315 | cell-based format |
| CHEMBL4555963 |  |
IC50 | = | 950.0 | nM | 357.19 | O=C(NCc1cccc(Br)c1)Nc1ncc([N+](=O)[O-])s1 | Homo sapiens | CHEMBL4482757 | single protein format |
| CHEMBL4579064 |  |
IC50 | = | 950.0 | nM | 344.35 | O=C(CF)CNC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1 | Homo sapiens | CHEMBL4480315 | cell-based format |
| CHEMBL4542508 |  |
IC50 | = | 1000.0 | nM | 354.39 | O=C(NCc1ccc(-c2ccccc2)cc1)Nc1ncc([N+](=O)[O-])s1 | Homo sapiens | CHEMBL4482757 | single protein format |