Q9Y4K4 | M4K5_HUMAN | Mitogen-activated protein kinase kinase kinase kinase 5 (MAP4K5)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 20~277 | |
| PF00780 | CNH - CNH domain | 522~812 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL288441 |  |
IC50 | = | 0.3 | nM | 530.46 | COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl | Homo sapiens | CHEMBL1244320 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 0.309 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328465 | single protein format |
| CHEMBL4793665 |  |
IC50 | = | 6.4 | nM | 395.53 | CCN1CCC(c2ncc(-c3cnc(N)c(OCc4ccncc4)c3)s2)CC1 | Homo sapiens | CHEMBL4674069 | single protein format |
| CHEMBL3770443 |  |
IC50 | = | 10.0 | nM | 492.97 | CNc1ncc2cc(-c3ccc(-c4cccc(C)n4)cc3Cl)c(=O)n(C[C@H]3OC[C@H](N)CO3)c2n1 | Homo sapiens | CHEMBL3772530 | single protein format |
| CHEMBL5409039 |  |
IC50 | = | 22.0 | nM | 539.64 | CC(C)(O)Cn1cc(-c2cnc3nc2N[C@H](CO)c2ccccc2OCCCCc2cc(ccc2C#N)N3)cn1 | Homo sapiens | CHEMBL5317045 | single protein format |
| CHEMBL5396594 |  |
IC50 | = | 25.2 | nM | 477.5 | [2H]C([2H])(O)[C@@H](Nc1nc(Nc2ccc3c(c2)C(C)(C)NC3=O)ncc1-c1nnco1)c1ccc(F)cc1 | Homo sapiens | CHEMBL5377068 | cell-based format |
| CHEMBL4281823 |  |
IC50 | = | 37.0 | nM | 481.48 | CCn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc21 | Homo sapiens | CHEMBL4261412 | single protein format |
| CHEMBL5174830 |  |
IC50 | = | 89.0 | nM | 331.42 | CN(C)CC#Cc1ccc2[nH]c3c(c2c1)-c1nc(N)ncc1CCC3 | Homo sapiens | CHEMBL5479569 | single protein format |
| CHEMBL5090394 |  |
IC50 | = | 210.0 | nM | 496.93 | CNc1ncc2cc(-c3ccc(-c4ncccc4F)cc3Cl)c(=O)n(C[C@H]3OC[C@H](N)CO3)c2n1 | Homo sapiens | CHEMBL5151382 | single protein format |
| CHEMBL4748154 |  |
IC50 | = | 231.9 | nM | 458.48 | CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nnco4)c(N[C@H](CO)c4ccccc4)n3)cc21 | Homo sapiens | CHEMBL5377068 | cell-based format |
| CHEMBL5083143 |  |
IC50 | = | 539.0 | nM | 406.49 | c1ccc2c(-c3coc4cc(-c5ccc(N6CCNCC6)cc5)cnc34)ccnc2c1 | Homo sapiens | CHEMBL5478947 | single protein format |
| CHEMBL4793380 |  |
IC50 | = | 711.0 | nM | 423.48 | CC(C)(C)c1cc(NC(=O)Nc2ccc(Nc3ncnc4c3OCCCN4)cc2)no1 | Homo sapiens | CHEMBL4767011 | single protein format |
| CHEMBL3577124 |  |
IC50 | = | 970.0 | nM | 424.52 | CNc1ncc2cc(-c3cc(NC(=O)NCCC(C)(C)C)c(F)cc3C)c(C)nc2n1 | Homo sapiens | CHEMBL3578904 | cell-based format |