Q9Y4D2 | DGLA_HUMAN | Diacylglycerol lipase-alpha (DAGLA)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01764 | Lipase_3 - Lipase (class 3) | 394~529 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3764017 |  |
IC50 | = | 0.6 | nM | 574.53 | CC1(C)CCc2cc(S(=O)(=O)N(CC(=O)O)C3(c4cccc(-c5cc(Cl)cc(Cl)c5)c4)CCC3)ccc2O1 | Homo sapiens | CHEMBL3768666 | cell-based format |
| CHEMBL3765578 |  |
IC50 | = | 0.9 | nM | 588.55 | CC1(C)CCc2cc(S(=O)(=O)N(CC(=O)O)C3(c4cccc(-c5cc(Cl)cc(Cl)c5)c4)CCCC3)ccc2O1 | Homo sapiens | CHEMBL3768666 | cell-based format |
| CHEMBL3764876 |  |
IC50 | = | 2.4 | nM | 502.32 | O=C(O)CN(c1cccc(-c2cccc(Cl)c2Cl)c1)S(=O)(=O)c1ccc(OC(F)F)cc1 | Homo sapiens | CHEMBL3768666 | cell-based format |
| CHEMBL3765716 |  |
IC50 | = | 3.0 | nM | 534.46 | CC1(C)CCc2cc(S(=O)(=O)N(CC(=O)O)Cc3ccc(-c4cc(Cl)cc(Cl)c4)cc3)ccc2O1 | Homo sapiens | CHEMBL3768666 | cell-based format |
| CHEMBL3763826 |  |
IC50 | = | 3.0 | nM | 534.46 | CC1(C)CCc2cc(S(=O)(=O)N(CC(=O)O)Cc3cccc(-c4cc(Cl)cc(Cl)c4)c3)ccc2O1 | Homo sapiens | CHEMBL3768666 | cell-based format |
| CHEMBL3763853 |  |
IC50 | = | 3.0 | nM | 516.35 | O=C(O)CN(Cc1cccc(-c2cccc(Cl)c2Cl)c1)S(=O)(=O)c1ccc(OC(F)F)cc1 | Homo sapiens | CHEMBL3768666 | cell-based format |
| CHEMBL3763831 |  |
IC50 | = | 4.0 | nM | 524.85 | O=C(O)CN(C1(c2cccc(-c3cc(Cl)cc(Cl)c3)c2)CCC1)S(=O)(=O)c1ccc(Cl)cc1 | Homo sapiens | CHEMBL3768666 | cell-based format |
| CHEMBL3765421 |  |
IC50 | = | 6.0 | nM | 556.41 | O=C(O)CN(C1(c2ccc(-c3ccc(Cl)cc3Cl)cc2)CCC1)S(=O)(=O)c1ccc(OC(F)F)cc1 | Homo sapiens | CHEMBL3768666 | cell-based format |
| CHEMBL3764093 |  |
IC50 | = | 6.0 | nM | 559.3 | O=C(O)CN(C1(c2cccc(-c3ccc(Cl)cc3Cl)c2)CCC1)S(=O)(=O)c1ccc(Cl)c(Cl)c1 | Homo sapiens | CHEMBL3768666 | cell-based format |
| CHEMBL3763430 |  |
IC50 | = | 8.0 | nM | 590.53 | CC1(C)CCc2cc(S(=O)(=O)N(CC(=O)O)C3(c4ccc(-c5cc(Cl)cc(Cl)c5)cc4)CCOC3)ccc2O1 | Homo sapiens | CHEMBL3768666 | cell-based format |
| CHEMBL3765022 |  |
IC50 | = | 8.0 | nM | 571.52 | O=C(O)CN(C1(c2ccc(-c3ccccc3OC(F)(F)F)cc2)CCC1)S(=O)(=O)c1ccc(OC(F)F)cc1 | Homo sapiens | CHEMBL3768666 | cell-based format |
| CHEMBL3765158 |  |
IC50 | = | 11.0 | nM | 556.41 | O=C(O)CN(C1(c2cccc(-c3cc(Cl)cc(Cl)c3)c2)CCC1)S(=O)(=O)c1ccc(OC(F)F)cc1 | Homo sapiens | CHEMBL3768666 | cell-based format |
| CHEMBL3765824 |  |
IC50 | = | 16.0 | nM | 516.35 | O=C(O)CN(Cc1cccc(-c2cc(Cl)cc(Cl)c2)c1)S(=O)(=O)c1ccc(OC(F)F)cc1 | Homo sapiens | CHEMBL3768666 | cell-based format |
| CHEMBL521157 |  |
IC50 | = | 16.0 | nM | 495.75 | CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H](NC=O)C(C)CC | Homo sapiens | CHEMBL982702 | cell-based format |
| CHEMBL3764377 |  |
IC50 | = | 17.0 | nM | 531.46 | O=C(O)CN(Cc1cccc(-c2ccccc2OC(F)(F)F)c1)S(=O)(=O)c1ccc(OC(F)F)cc1 | Homo sapiens | CHEMBL3768666 | cell-based format |
| CHEMBL3764778 |  |
IC50 | = | 17.0 | nM | 531.46 | O=C(O)CN(Cc1ccc(-c2ccccc2OC(F)(F)F)cc1)S(=O)(=O)c1ccc(OC(F)F)cc1 | Homo sapiens | CHEMBL3768666 | cell-based format |
| CHEMBL3765573 |  |
IC50 | = | 18.0 | nM | 530.38 | C[C@@H](c1ccc(-c2ccc(Cl)cc2Cl)cc1)N(CC(=O)O)S(=O)(=O)c1ccc(OC(F)F)cc1 | Homo sapiens | CHEMBL3768666 | cell-based format |
| CHEMBL3319620 |  |
IC50 | = | 18.0 | nM | 481.57 | CC1(C)CCc2cc(S(=O)(=O)N(CC(=O)O)Cc3ccc(Oc4ccccc4)cc3)ccc2O1 | Homo sapiens | CHEMBL3373886 | cell-based format |
| CHEMBL3765497 |  |
IC50 | = | 19.0 | nM | 530.38 | C[C@H](c1ccc(-c2ccc(Cl)cc2Cl)cc1)N(CC(=O)O)S(=O)(=O)c1ccc(OC(F)F)cc1 | Homo sapiens | CHEMBL3768666 | cell-based format |
| CHEMBL3765546 |  |
IC50 | = | 30.0 | nM | 516.35 | O=C(O)CN(Cc1ccc(-c2ccc(Cl)cc2Cl)cc1)S(=O)(=O)c1ccc(OC(F)F)cc1 | Homo sapiens | CHEMBL3768666 | cell-based format |