Q9Y478 | AAKB1_HUMAN | 5'-AMP-activated protein kinase subunit beta-1 (PRKAB1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF04739 | AMPKBI - 5'-AMP-activated protein kinase beta subunit, interaction domain | 201~269 | |
| PF16561 | AMPK1_CBM - Glycogen recognition site of AMP-activated protein kinase | 79~160 |
3D structures mapped by conservation among orthologs
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // AMPK1_CBM ]
[ Domain: "AMPKBI-like" // AMPKBI ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2385579 |  |
IC50 | = | 39.9 | nM | 346.39 | c1cc(N2CCOCC2)ccc1-c1cnc2c(-c3cn[nH]c3)cnn2c1 | Homo sapiens | CHEMBL2390519 | single protein format |
| CHEMBL2385600 |  |
IC50 | = | 44.0 | nM | 291.31 | COc1ccc(-c2cnc3c(-c4cn[nH]c4)cnn3c2)cc1 | Homo sapiens | CHEMBL2390519 | single protein format |
| CHEMBL2385586 |  |
IC50 | = | 82.0 | nM | 345.41 | c1cc(N2CCNCC2)ccc1-c1cnc2c(-c3cn[nH]c3)cnn2c1 | Homo sapiens | CHEMBL2390519 | single protein format |
| CHEMBL478629 |  |
IC50 | = | 234.6 | nM | 399.5 | c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)ccn1 | Homo sapiens | CHEMBL2390519 | single protein format |
| CHEMBL3891221 |  |
IC50 | = | 400.0 | nM | 341.79 | O=C(O)c1c[nH]c2cc(Cl)c(-c3ccc(C4(O)CCC4)cc3)cc12 | Homo sapiens | CHEMBL4234628 | cell-based format |
| CHEMBL3986871 |  |
IC50 | = | 420.0 | nM | 345.79 | COc1nc(N(C)C)ccc1-c1cc2c(C(=O)O)c[nH]c2cc1Cl | Homo sapiens | CHEMBL4234628 | cell-based format |
| CHEMBL3668018 |  |
IC50 | = | 527.0 | nM | 451.53 | c1ccc2c(-c3cnn4cc(-c5ccc(OCCN6CCOCC6)cc5)cnc34)ccnc2c1 | Homo sapiens | CHEMBL3707742 | single protein format |
| CHEMBL2385596 |  |
IC50 | = | 960.0 | nM | 420.52 | CN1CCN(c2ccc(-c3cnc4c(-c5ccnc6ccccc56)cnn4c3)cc2)CC1 | Homo sapiens | CHEMBL2390519 | single protein format |
| CHEMBL2205426 |  |
Ki | = | 333.0 | nM | 414.47 | CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(-c4ccncc4)cc3)n2)c(=O)c1=O | Homo sapiens | CHEMBL2210936 | single protein format |