Q9Y463 | DYR1B_HUMAN | Dual specificity tyrosine-phosphorylation-regulated kinase 1B (DYRK1B)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 111~431 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5438158 |  |
IC50 | = | 0.0 | nM | 396.49 | O=C1NC(NC23CC4CC(CC(F)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5363959 | single protein format |
| CHEMBL4797548 |  |
IC50 | = | 0.002 | nM | 339.37 | Fc1ccccc1-n1cc(-c2ccnc(NC3CCOCC3)n2)cn1 | Homo sapiens | CHEMBL4742614 | single protein format |
| CHEMBL4794264 |  |
IC50 | = | 0.003 | nM | 375.44 | COc1ccccc1-n1cc(-c2ccnc(NCc3c(C)n[nH]c3C)n2)cn1 | Homo sapiens | CHEMBL4742614 | single protein format |
| CHEMBL4785938 |  |
IC50 | = | 0.003 | nM | 283.31 | CCNc1nccc(-c2cnn(-c3ccccc3F)c2)n1 | Homo sapiens | CHEMBL4742614 | single protein format |
| CHEMBL4787263 |  |
IC50 | = | 0.004 | nM | 346.37 | Fc1ccccc1-n1cc(-c2ccnc(NCc3ccncc3)n2)cn1 | Homo sapiens | CHEMBL4742614 | single protein format |
| CHEMBL2386744 |  |
IC50 | = | 0.24 | nM | 432.28 | COC(=N)c1nc2ccc3ncnc(Nc4ccc(Br)cc4F)c3c2s1 | Homo sapiens | CHEMBL2388920 | single protein format |
| CHEMBL2386747 |  |
IC50 | = | 0.28 | nM | 404.28 | COC(=N)c1nc2ccc3ncnc(Nc4ccc(Cl)cc4Cl)c3c2s1 | Homo sapiens | CHEMBL2388920 | single protein format |
| CHEMBL3894571 |  |
IC50 | = | 0.59 | nM | 383.41 | COC(=N)c1nc2ccc3ncnc(Nc4ccc(OC)cc4F)c3c2s1 | Homo sapiens | CHEMBL3889023 | single protein format |
| CHEMBL2386745 |  |
IC50 | = | 0.59 | nM | 383.41 | COC(=N)c1nc2ccc3ncnc(Nc4ccc(F)cc4OC)c3c2s1 | Homo sapiens | CHEMBL2388920 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 0.967 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328391 | single protein format |
| CHEMBL5400230 |  |
IC50 | = | 1.0 | nM | 364.47 | O=C1NC(NC23CC4CC(CC2C4)C3)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5363959 | single protein format |
| CHEMBL5082044 |  |
IC50 | = | 1.0 | nM | 336.42 | Cc1nc(NCc2cccs2)c2c(-c3ccnc(N)c3)c[nH]c2n1 | Homo sapiens | CHEMBL5034570 | single protein format |
| CHEMBL5092157 |  |
IC50 | = | 1.0 | nM | 330.4 | Cc1nc(NCc2ccccc2)c2c(-c3ccnc(N)c3)c[nH]c2n1 | Homo sapiens | CHEMBL5034570 | single protein format |
| CHEMBL5091510 |  |
IC50 | = | 1.0 | nM | 337.41 | Cc1nc(OCc2ccsc2)c2c(-c3ccnc(N)c3)c[nH]c2n1 | Homo sapiens | CHEMBL5034570 | single protein format |
| CHEMBL3421963 |  |
IC50 | = | 1.0 | nM | 415.5 | COc1cc(N2CCN(C)CC2)ccc1Nc1cc(-c2c[nH]c3cnccc23)ncn1 | Homo sapiens | CHEMBL3424978 | single protein format |
| CHEMBL5090676 |  |
IC50 | = | 1.0 | nM | 338.4 | Cc1nc(OCc2cncs2)c2c(-c3ccnc(N)c3)c[nH]c2n1 | Homo sapiens | CHEMBL5034570 | single protein format |
| CHEMBL5083159 |  |
IC50 | = | 1.0 | nM | 336.42 | Cc1nc(NCc2ccsc2)c2c(-c3ccnc(N)c3)c[nH]c2n1 | Homo sapiens | CHEMBL5034570 | single protein format |
| CHEMBL5405059 |  |
IC50 | = | 1.0 | nM | 394.5 | O=C1NC(NC23CC4CC(CC(O)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5363959 | single protein format |
| CHEMBL5422486 |  |
IC50 | = | 1.0 | nM | 432.47 | O=C1NC(NC23CC4(F)CC(F)(CC(F)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5363959 | single protein format |
| CHEMBL2386748 |  |
IC50 | = | 1.07 | nM | 371.37 | COC(=N)c1nc2ccc3ncnc(Nc4ccc(F)cc4F)c3c2s1 | Homo sapiens | CHEMBL2388920 | single protein format |