Q9Y345 | SC6A5_HUMAN | Sodium- and chloride-dependent glycine transporter 2 (SLC6A5)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00209 | SNF - Sodium:neurotransmitter symporter family | 191~737 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3325502 |  |
IC50 | = | 15.3 | nM | 463.54 | CN(C)CCCN1CCC(NC(=O)c2ccc(COc3ccc(C(F)(F)F)cc3)cc2)CC1 | Homo sapiens | CHEMBL3390091 | cell-based format |
| CHEMBL88588 |  |
IC50 | = | 16.0 | nM | 412.53 | COc1cc(C(=O)NCC2(N(C)C)CCCC2)cc(OC)c1OCc1ccccc1 | Homo sapiens | CHEMBL680554 | single protein format |
| CHEMBL153717 |  |
IC50 | = | 24.0 | nM | 412.53 | O=C(NCC/C=C/c1ccccc1)c1ccccc1CN1CCc2ccc(O)cc2C1 | Homo sapiens | CHEMBL680555 | assay format |
| CHEMBL4587165 |  |
IC50 | = | 25.5 | nM | 447.1 | CCCCCCCC/C=C\CCCCCCCC(=O)N[C@@H](CCCCN)C(=O)O.Cl | Homo sapiens | CHEMBL4481230 | cell-based format |
| CHEMBL4515597 |  |
IC50 | = | 29.2 | nM | 413.67 | CCCCCCCC/C=C\CCCCCCCC(=O)N[C@@H](CCSC)C(=O)O | Homo sapiens | CHEMBL4481230 | cell-based format |
| CHEMBL153731 |  |
IC50 | = | 30.0 | nM | 426.56 | CC1c2cc(O)ccc2CCN1Cc1ccccc1C(=O)NCC/C=C/c1ccccc1 | Homo sapiens | CHEMBL680555 | assay format |
| CHEMBL239601 |  |
IC50 | = | 31.5 | nM | 492.6 | OCC1(N2CCN(C3CCc4ccc(OCc5noc(-c6ccccc6F)n5)cc43)CC2)CCCC1 | Homo sapiens | CHEMBL903409 | cell-based format |
| CHEMBL4572247 |  |
IC50 | = | 31.6 | nM | 433.08 | CCCCCCCC/C=C\CCCCCCCC(=O)N[C@@H](CCCN)C(=O)O.Cl | Homo sapiens | CHEMBL4481230 | cell-based format |
| CHEMBL358473 |  |
IC50 | = | 33.0 | nM | 398.51 | O=C(NCC/C=C/c1ccccc1)c1ccccc1CN1Cc2ccc(O)cc2C1 | Homo sapiens | CHEMBL680555 | assay format |
| CHEMBL155273 |  |
IC50 | = | 43.0 | nM | 426.56 | O=C(NCC/C=C/c1ccccc1)c1ccccc1CNC1CCc2cc(O)ccc2C1 | Homo sapiens | CHEMBL680555 | assay format |
| CHEMBL4562565 |  |
IC50 | = | 47.9 | nM | 511.58 | CCCCCCCC/C=C\CCCCCCCC(=O)N[C@@H](CCCNC(=N)N)C(=O)O.Cl.Cl | Homo sapiens | CHEMBL4481230 | cell-based format |
| CHEMBL4535356 |  |
IC50 | = | 48.3 | nM | 447.1 | CCCCCCCC/C=C\CCCCCCCC(=O)N[C@H](CCCCN)C(=O)O.Cl | Homo sapiens | CHEMBL4481230 | cell-based format |
| CHEMBL3325511 |  |
IC50 | = | 51.9 | nM | 469.51 | O=C(NC1CCN(Cc2cccnc2)CC1)c1ccc(COc2ccc(C(F)(F)F)cc2)cc1 | Homo sapiens | CHEMBL3390091 | cell-based format |
| CHEMBL4227139 |  |
IC50 | = | 54.6 | nM | 468.68 | CCCCCCCC/C=C\CCCCCCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | Homo sapiens | CHEMBL4481230 | cell-based format |
| CHEMBL153630 |  |
IC50 | = | 56.0 | nM | 400.52 | O=C(NCC/C=C/c1ccccc1)c1ccccc1CNCCc1ccc(O)cc1 | Homo sapiens | CHEMBL680555 | assay format |
| CHEMBL150560 |  |
IC50 | = | 58.0 | nM | 426.56 | O=C(NCC/C=C/c1ccccc1)c1ccccc1CN1CCc2ccc(O)cc2CC1 | Homo sapiens | CHEMBL680555 | assay format |
| CHEMBL3325505 |  |
IC50 | = | 62.1 | nM | 468.52 | O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc(COc2ccc(C(F)(F)F)cc2)cc1 | Homo sapiens | CHEMBL3390091 | cell-based format |
| CHEMBL4527071 |  |
IC50 | = | 64.8 | nM | 369.55 | CCCCCCCC/C=C\CCCCCCCC(=O)N[C@H](CO)C(=O)O | Homo sapiens | CHEMBL4481230 | cell-based format |
| CHEMBL3325509 |  |
IC50 | = | 65.8 | nM | 422.45 | O=C(NC1CCN(CCO)CC1)c1ccc(COc2ccc(C(F)(F)F)cc2)cc1 | Homo sapiens | CHEMBL3390091 | cell-based format |
| CHEMBL150377 |  |
IC50 | = | 67.0 | nM | 426.56 | CC1Cc2ccc(O)cc2CN1Cc1ccccc1C(=O)NCC/C=C/c1ccccc1 | Homo sapiens | CHEMBL680555 | assay format |