Q9Y2U5 | M3K2_HUMAN | Mitogen-activated protein kinase kinase kinase 2 (MAP3K2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 358~615 | |
| PF00564 | PB1 - PB1 domain | 44~120 |
3D structures mapped by conservation among orthologs
[ Domain: "Ubiquitin-like" // PB1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL388978 |  |
IC50 | = | 43.5 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328492 | single protein format |
| CHEMBL4554938 |  |
IC50 | = | 79.6 | nM | 416.49 | CN1C(=O)c2sccc2N(C)c2nc(Nc3ccc(S(N)(=O)=O)cc3)ncc21 | Homo sapiens | CHEMBL5212981 | single protein format |
| CHEMBL5404574 |  |
IC50 | < | 100.0 | nM | 465.51 | COC[C@@H](C)OC(=O)Cc1ccc(Nc2cc(Nc3ccccc3OC)c(C(N)=O)cn2)nc1 | Homo sapiens | CHEMBL5375204 | single protein format |
| CHEMBL5407329 |  |
IC50 | < | 100.0 | nM | 393.4 | COc1ccccc1Nc1cc(Nc2ccc(CC(=O)O)cn2)ncc1C(N)=O | Homo sapiens | CHEMBL5375204 | single protein format |
| CHEMBL4281823 |  |
IC50 | = | 255.0 | nM | 481.48 | CCn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc21 | Homo sapiens | CHEMBL4261413 | single protein format |
| CHEMBL2436978 |  |
IC50 | = | 661.0 | nM | 421.55 | CN1CCN(Cc2ccc(-c3cnc4[nH]cc(-c5ccc6[nH]ccc6c5)c4c3)cc2)CC1 | Homo sapiens | CHEMBL2439759 | single protein format |
| CHEMBL4436748 |  |
IC50 | = | 910.0 | nM | 459.59 | Nc1c(C(=O)NCc2ccc(C(=O)NCCCC3CCCCC3)cc2)cnn1-c1ccccc1 | Homo sapiens | CHEMBL4324190 | cell-based format |