Q9Y2R2 | PTN22_HUMAN | Tyrosine-protein phosphatase non-receptor type 22 (PTPN22)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00102 | Y_phosphatase - Protein-tyrosine phosphatase | 54~288 |
3D structures mapped by conservation among orthologs
[ Domain: "(Phosphotyrosine protein) phosphatases II" // Y_phosphatase ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1701224 |  |
IC50 | = | 113.0 | nM | 506.97 | O=C(O)COc1ccc(/C=N/NC(=O)c2ccc(-c3csc(Nc4ccc(Cl)cc4)n3)cc2)cc1 | Homo sapiens | CHEMBL1738445 | single protein format |
| CHEMBL2396718 |  |
IC50 | = | 171.0 | nM | 503.94 | CCCNC(=O)COc1ccc(-c2oc3cc(O)c(C(=O)O)cc3c2C#Cc2cccc(Cl)c2)cc1 | Homo sapiens | CHEMBL2401204 | assay format |
| CHEMBL2396719 |  |
IC50 | = | 259.0 | nM | 501.92 | O=C(COc1ccc(-c2oc3cc(O)c(C(=O)O)cc3c2C#Cc2cccc(Cl)c2)cc1)NC1CC1 | Homo sapiens | CHEMBL2401470 | assay format |
| CHEMBL2396720 |  |
IC50 | = | 263.0 | nM | 537.96 | O=C(COc1ccc(-c2oc3cc(O)c(C(=O)O)cc3c2C#Cc2cccc(Cl)c2)cc1)Nc1ccccc1 | Homo sapiens | CHEMBL2401204 | assay format |
| CHEMBL2396717 |  |
IC50 | = | 300.0 | nM | 580.04 | CC(C)c1ccc(NC(=O)COc2cccc(-c3oc4cc(O)c(C(=O)O)cc4c3C#Cc3cccc(Cl)c3)c2)cc1 | Homo sapiens | CHEMBL2401470 | assay format |
| CHEMBL2396721 |  |
IC50 | = | 310.0 | nM | 596.08 | O=C(COc1ccc(-c2oc3cc(O)c(C(=O)O)cc3c2C#Cc2cccc(Cl)c2)cc1)NC12CC3CC(CC(C3)C1)C2 | Homo sapiens | CHEMBL2401204 | assay format |
| CHEMBL1650889 |  |
IC50 | = | 340.0 | nM | 562.58 | COc1ccc(-c2oc3cc(O)c(C(=O)O)cc3c2-c2cn(CCCC(=O)Nc3cccc4ccccc34)nn2)cc1 | Homo sapiens | CHEMBL1664624 | single protein format |
| CHEMBL1650891 |  |
IC50 | = | 380.0 | nM | 581.03 | Cc1ccc(-c2oc3cc(O)c(C(=O)O)cc3c2-c2cn(CCCC(=O)Nc3ccc(Cl)c4ccccc34)nn2)cc1 | Homo sapiens | CHEMBL1664624 | single protein format |
| CHEMBL442448 |  |
IC50 | = | 390.0 | nM | 433.46 | COC(=O)c1cc(-c2ccc(/C=C3\SC(=O)N(CCC(=O)O)C3=O)s2)ccc1O | Homo sapiens | CHEMBL927977 | single protein format |
| CHEMBL1650892 |  |
IC50 | = | 410.0 | nM | 546.58 | Cc1ccc(-c2oc3cc(O)c(C(=O)O)cc3c2-c2cn(CCCC(=O)Nc3cccc4ccccc34)nn2)cc1 | Homo sapiens | CHEMBL1664624 | single protein format |
| CHEMBL1650893 |  |
IC50 | = | 520.0 | nM | 583.63 | COc1ccc2nc(NC(=O)CCCn3cc(-c4c(-c5cccc(C)c5)oc5cc(O)c(C(=O)O)cc45)nn3)sc2c1 | Homo sapiens | CHEMBL1664624 | single protein format |
| CHEMBL1650894 |  |
IC50 | = | 560.0 | nM | 567.0 | O=C(CCCn1cc(-c2c(-c3ccccc3)oc3cc(O)c(C(=O)O)cc23)nn1)Nc1ccc(Cl)c2ccccc12 | Homo sapiens | CHEMBL1664624 | single protein format |
| CHEMBL1650895 |  |
IC50 | = | 610.0 | nM | 571.59 | Cc1cccc(-c2oc3cc(O)c(C(=O)O)cc3c2-c2cn(CCCC(=O)Nc3nc4ccc(F)cc4s3)nn2)c1 | Homo sapiens | CHEMBL1664624 | single protein format |
| CHEMBL2396714 |  |
IC50 | = | 610.0 | nM | 507.25 | O=C(O)c1cc2c(C#Cc3ccc(Cl)c(Cl)c3)c(-c3ccc(OC(F)(F)F)cc3)oc2cc1O | Homo sapiens | CHEMBL2401204 | assay format |
| CHEMBL2316908 |  |
IC50 | = | 630.0 | nM | 446.46 | O=C(O)c1cc2c(C#Cc3ccc(Oc4ccccc4)cc3)c(-c3ccccc3)oc2cc1O | Homo sapiens | CHEMBL2317716 | assay format |
| CHEMBL1650896 |  |
IC50 | = | 640.0 | nM | 591.58 | Cc1ccc(-c2oc3cc(O)c(C(=O)O)cc3c2-c2cn(CCCC(=O)Nc3ccc([N+](=O)[O-])c4ccccc34)nn2)cc1 | Homo sapiens | CHEMBL1664624 | single protein format |
| CHEMBL1650898 |  |
IC50 | = | 650.0 | nM | 510.55 | Cc1cccc(-c2oc3cc(O)c(C(=O)O)cc3c2-c2cn(CCCC(=O)NCc3ccccc3)nn2)c1 | Homo sapiens | CHEMBL1664624 | single protein format |
| CHEMBL1650897 |  |
IC50 | = | 650.0 | nM | 496.52 | Cc1cccc(-c2oc3cc(O)c(C(=O)O)cc3c2-c2cn(CCCC(=O)Nc3ccccc3)nn2)c1 | Homo sapiens | CHEMBL1664624 | single protein format |
| CHEMBL2396713 |  |
IC50 | = | 680.0 | nM | 472.8 | O=C(O)c1cc2c(C#Cc3cccc(Cl)c3)c(-c3ccc(OC(F)(F)F)cc3)oc2cc1O | Homo sapiens | CHEMBL2401470 | assay format |
| CHEMBL1650900 |  |
IC50 | = | 740.0 | nM | 496.52 | O=C(CCCn1cc(-c2c(-c3ccccc3)oc3cc(O)c(C(=O)O)cc23)nn1)NCc1ccccc1 | Homo sapiens | CHEMBL1664624 | single protein format |