Q9Y2K2 | SIK3_HUMAN | Serine/threonine-protein kinase SIK3 (SIK3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 66~317 | |
| PF23312 | UBA_SIK3 - Protein kinase SIK3 UBA domain | 348~385 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5417444 |  |
IC50 | = | 0.6 | nM | 453.45 | COc1cc(-n2cnc3cc(-c4cnn(C)c4)ccc32)cc(OC(F)F)c1C(=O)NC1CC1 | Homo sapiens | CHEMBL5338277 | single protein format |
| CHEMBL5440720 |  |
IC50 | = | 0.6 | nM | 501.53 | COc1cc(-c2cnc3cc(OCCC4CCOCC4)ccn23)cc(OC(F)F)c1C(=O)NC1CC1 | Homo sapiens | CHEMBL5338277 | single protein format |
| CHEMBL5431938 |  |
IC50 | = | 1.0 | nM | 455.47 | CCNC(=O)c1c(OC)cc(-n2cnc3cc(-c4cnn(CC)c4)ccc32)cc1OC(F)F | Homo sapiens | CHEMBL5345753 | cell-based format |
| CHEMBL5438171 |  |
IC50 | = | 1.0 | nM | 391.43 | CCn1cc(-c2ccc3c(c2)ncn3-c2cc(OC)c(C(N)=O)c(OC)c2)cn1 | Homo sapiens | CHEMBL5345753 | cell-based format |
| CHEMBL5415380 |  |
IC50 | = | 1.1 | nM | 441.44 | CCNC(=O)c1c(OC)cc(-n2cnc3cc(-c4cnn(C)c4)ccc32)cc1OC(F)F | Homo sapiens | CHEMBL5345753 | cell-based format |
| CHEMBL5407103 |  |
IC50 | = | 1.2 | nM | 430.47 | CCc1nnc(-c2c(OC)cc(-c3cnc4cc(-c5cnn(C)c5)ccn34)cc2OC)o1 | Homo sapiens | CHEMBL5338274 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 1.24 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328605 | single protein format |
| CHEMBL5412961 |  |
IC50 | = | 1.3 | nM | 431.5 | CCn1cc(-c2ccc3c(c2)ncn3-c2cc(OC)c(C(=O)NC3CC3)c(OC)c2)cn1 | Homo sapiens | CHEMBL5345753 | cell-based format |
| CHEMBL5402124 |  |
IC50 | = | 1.4 | nM | 499.52 | COc1cc(-c2cnc3cc(N4CCN(C(C)=O)CC4)ccn23)cc(OC(F)F)c1C(=O)NC1CC1 | Homo sapiens | CHEMBL5338277 | single protein format |
| CHEMBL5404502 |  |
IC50 | = | 1.4 | nM | 473.46 | CCn1cc(-c2ccc3c(c2)ncn3-c2cc(OC)c(C(=O)NCC(F)(F)F)c(OC)c2)cn1 | Homo sapiens | CHEMBL5338277 | single protein format |
| CHEMBL5405883 |  |
IC50 | = | 1.7 | nM | 499.56 | COc1cc(-c2cnc3cc(N4CCC(N(C)C)CC4)ccn23)cc(OC(F)F)c1C(=O)NC1CC1 | Homo sapiens | CHEMBL5338277 | single protein format |
| CHEMBL5439455 |  |
IC50 | = | 1.7 | nM | 464.42 | COc1cc(-c2cnc3cc(N4CC(F)(F)C4)ccn23)cc(OC(F)F)c1C(=O)NC1CC1 | Homo sapiens | CHEMBL5338277 | single protein format |
| CHEMBL5437300 |  |
IC50 | = | 1.7 | nM | 502.52 | COc1cc(-c2cnc3cc(OCCN4CCOCC4)ccn23)cc(OC(F)F)c1C(=O)NC1CC1 | Homo sapiens | CHEMBL5338277 | single protein format |
| CHEMBL5410472 |  |
IC50 | = | 1.9 | nM | 501.53 | COc1cc(-c2cnc3cc(N4CCN(CCO)CC4)ccn23)cc(OC(F)F)c1C(=O)NC1CC1 | Homo sapiens | CHEMBL5338277 | single protein format |
| CHEMBL5397288 |  |
IC50 | = | 2.2 | nM | 430.47 | CCNC(=O)c1c(OC)cc(-n2cnc3cc(-c4cnn(CC#N)c4)ccc32)cc1OC | Homo sapiens | CHEMBL5345753 | cell-based format |
| CHEMBL5401167 |  |
IC50 | = | 2.9 | nM | 419.49 | CCNC(=O)c1c(OC)cc(-n2cnc3cc(-c4cnn(CC)c4)ccc32)cc1OC | Homo sapiens | CHEMBL5345753 | cell-based format |
| CHEMBL5419090 |  |
IC50 | = | 3.1 | nM | 471.51 | COc1cc(-c2cnc3cc(N4CCN(C)CC4)ccn23)cc(OC(F)F)c1C(=O)NC1CC1 | Homo sapiens | CHEMBL5338277 | single protein format |
| CHEMBL5440381 |  |
IC50 | = | 3.2 | nM | 470.4 | COc1cc(-c2cnc3cc(N4CC(F)(F)C4)ccn23)cc(OC)c1C(=O)NCC(F)(F)F | Homo sapiens | CHEMBL5338277 | single protein format |
| CHEMBL5410039 |  |
IC50 | = | 3.6 | nM | 500.5 | COc1cc(-c2cnc3cc(NC(=O)C4CCOCC4)ccn23)cc(OC(F)F)c1C(=O)NC1CC1 | Homo sapiens | CHEMBL5338277 | single protein format |
| CHEMBL5427025 |  |
IC50 | = | 3.7 | nM | 378.43 | CCn1cc(-c2ccc3c(c2)ncn3-c2cc(OC)c(CO)c(OC)c2)cn1 | Homo sapiens | CHEMBL5345753 | cell-based format |