Q9Y2I7 | FYV1_HUMAN | 1-phosphatidylinositol 3-phosphate 5-kinase (PIKFYVE)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00118 | Cpn60_TCP1 - TCP-1/cpn60 chaperonin family | 610~855 | |
| PF00610 | DEP - Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) | 368~437 | |
| PF01363 | FYVE - FYVE zinc finger | 154~215 | |
| PF01504 | PIP5K - Phosphatidylinositol-4-phosphate 5-Kinase | 1858~2027 | |
| PF01504 | PIP5K - Phosphatidylinositol-4-phosphate 5-Kinase | 2029~2082 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2178735 |  |
IC50 | = | 0.82 | nM | 467.49 | Nc1ccc(C(=O)Nc2cccc(-c3nc(N4CCOCC4)c4oc5ncccc5c4n3)c2)cn1 | Homo sapiens | CHEMBL5111458 | cell-based format |
| CHEMBL5189479 |  |
IC50 | = | 1.8 | nM | 336.44 | CCC(O)(CC)c1ccc2[nH]c3c(c2c1)-c1nc(N)ncc1CCC3 | Homo sapiens | CHEMBL5111458 | cell-based format |
| CHEMBL5193848 |  |
IC50 | = | 1.9 | nM | 322.41 | CCC(C)(O)c1ccc2[nH]c3c(c2c1)-c1nc(N)ncc1CCC3 | Homo sapiens | CHEMBL5111458 | cell-based format |
| CHEMBL2334586 |  |
IC50 | = | 2.2 | nM | 332.41 | CC(C)(O)C#Cc1ccc2[nH]c3c(c2c1)-c1nc(N)ncc1CCC3 | Homo sapiens | CHEMBL5111447 | assay format |
| CHEMBL4297643 |  |
IC50 | = | 3.4 | nM | 418.5 | Cc1cccc(/C=N/Nc2cc(N3CCOCC3)nc(OCCc3ccccn3)n2)c1 | Homo sapiens | CHEMBL5111458 | cell-based format |
| CHEMBL4303292 |  |
IC50 | = | 3.7 | nM | 413.49 | Cc1cccc(/C=N/Nc2cc(N3CCOCC3)n3nc(-c4ccncc4)cc3n2)c1 | Homo sapiens | CHEMBL5111458 | cell-based format |
| CHEMBL5171359 |  |
IC50 | = | 4.05 | nM | 294.36 | CC(O)c1ccc2[nH]c3c(c2c1)-c1nc(N)ncc1CCC3 | Homo sapiens | CHEMBL5111459 | cell-based format |
| CHEMBL5181163 |  |
IC50 | = | 6.1 | nM | 292.34 | CC(C)(O)C#Cc1ccc2[nH]cc(-c3ccnc(N)n3)c2c1 | Homo sapiens | CHEMBL5111458 | cell-based format |
| CHEMBL5198944 |  |
IC50 | = | 6.2 | nM | 322.41 | COC(C)(C)c1ccc2[nH]c3c(c2c1)-c1nc(N)ncc1CCC3 | Homo sapiens | CHEMBL5111458 | cell-based format |
| CHEMBL5174830 |  |
IC50 | = | 6.9 | nM | 331.42 | CN(C)CC#Cc1ccc2[nH]c3c(c2c1)-c1nc(N)ncc1CCC3 | Homo sapiens | CHEMBL5111458 | cell-based format |
| CHEMBL5207387 |  |
IC50 | = | 8.2 | nM | 330.37 | Nc1ncc2c(n1)-c1c([nH]c3ccc(-c4ccc(F)cc4)cc13)CC2 | Homo sapiens | CHEMBL5111458 | cell-based format |
| CHEMBL5194705 |  |
IC50 | = | 9.0 | nM | 577.43 | Ic1cccc(/C=N/Nc2nc(N3CCOCC3)nc(N(c3ccccc3)c3ccccc3)n2)c1 | Homo sapiens | CHEMBL5131986 | single protein format |
| CHEMBL5171753 |  |
IC50 | = | 9.3 | nM | 344.39 | Nc1ncc2c(n1)-c1c([nH]c3ccc(-c4ccc(F)cc4)cc13)CCC2 | Homo sapiens | CHEMBL5111458 | cell-based format |
| CHEMBL5190524 |  |
IC50 | = | 22.0 | nM | 351.41 | Nc1ncc2c(n1)-c1c([nH]c3ccc(C#Cc4ccncc4)cc13)CCC2 | Homo sapiens | CHEMBL5111458 | cell-based format |
| CHEMBL5188159 |  |
IC50 | = | 26.0 | nM | 330.39 | Cn1cc(-c2ccc3[nH]c4c(c3c2)-c2nc(N)ncc2CCC4)cn1 | Homo sapiens | CHEMBL5111458 | cell-based format |
| CHEMBL5200109 |  |
IC50 | = | 34.0 | nM | 316.37 | Cn1cc(-c2ccc3[nH]c4c(c3c2)-c2nc(N)ncc2CC4)cn1 | Homo sapiens | CHEMBL5111458 | cell-based format |
| CHEMBL5185288 |  |
IC50 | = | 40.0 | nM | 294.36 | Nc1ncc2c(n1)-c1c([nH]c3ccc(CCO)cc13)CCC2 | Homo sapiens | CHEMBL5111459 | cell-based format |
| CHEMBL4446338 |  |
IC50 | = | 40.1 | nM | 531.62 | CN(C)C/C=C/C(=O)Nc1ccc(C(=O)Nc2cccc(Nc3cc(-c4c[nH]c5ccccc45)ncn3)c2)cc1 | Homo sapiens | CHEMBL4345239 | single protein format |
| CHEMBL5190153 |  |
IC50 | = | 45.7 | nM | 346.43 | CC(C)C(O)C#Cc1ccc2[nH]c3c(c2c1)-c1nc(N)ncc1CCC3 | Homo sapiens | CHEMBL5111459 | cell-based format |
| CHEMBL5202422 |  |
IC50 | = | 61.0 | nM | 346.43 | CC(C)(O)C#Cc1ccc2[nH]c3c(c2c1)-c1nc(N)ncc1CCCC3 | Homo sapiens | CHEMBL5111458 | cell-based format |