Q9Y2I1 | NISCH_HUMAN | Nischarin (NISCH)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00787 | PX - PX domain | 37~117 | |
| PF23142 | PH_PLEKHM2 - PLEKHM2 PH domain-like | 1217~1285 | |
| PF25625 | PH_NISCH_C - Nischarin, C-terminal PH domain | 1347~1500 |
3D structures mapped by conservation among orthologs
[ Domain: "PX domain" // PX ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1933288 |  |
IC50 | = | 97.0 | nM | 458.57 | C[C@@H]1CCNC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5n4CCCN(C)C)cc3n21 | Homo sapiens | CHEMBL5213146 | single protein format |
| CHEMBL3546401 |  |
Ki | = | 0.22 | nM | 248.76 | CC1CN=C(Nc2ccc(Cl)c3c2CCC3)C1 | Homo sapiens | CHEMBL3888188 | assay format |
| CHEMBL3546402 |  |
Ki | = | 2.8 | nM | 228.34 | Cc1ccc(NC2=NCC(C)C2)c2c1CCC2 | Homo sapiens | CHEMBL3888188 | assay format |
| CHEMBL3546398 |  |
Ki | = | 2.8 | nM | 248.76 | CC1CCC(Nc2ccc(Cl)c3c2CCC3)=N1 | Homo sapiens | CHEMBL3888188 | assay format |
| CHEMBL360803 |  |
Ki | = | 4.8 | nM | 355.99 | Clc1cc(I)cc(Cl)c1N=C1NCCN1 | Homo sapiens | CHEMBL989166 | assay format |
| CHEMBL762 |  |
Ki | = | 6.2 | nM | 260.38 | Cc1cc(C(C)(C)C)c(O)c(C)c1CC1=NCCN1 | Homo sapiens | CHEMBL989166 | assay format |
| CHEMBL3547056 |  |
Ki | = | 8.1 | nM | 222.72 | Cc1c(Cl)cccc1NC1=NCC(C)C1 | Homo sapiens | CHEMBL3888188 | assay format |
| CHEMBL134 |  |
Ki | = | 8.9 | nM | 230.1 | Clc1cccc(Cl)c1NC1=NCCN1 | Homo sapiens | CHEMBL841852 | single protein format |
| CHEMBL275970 |  |
Ki | = | 10.0 | nM | 172.23 | C(=C/c1ccccc1)\C1=NCCN1 | Homo sapiens | CHEMBL841026 | assay format |
| CHEMBL597 |  |
Ki | = | 11.4 | nM | 281.36 | Cc1ccc(N(CC2=NCCN2)c2cccc(O)c2)cc1 | Homo sapiens | CHEMBL989166 | assay format |
| CHEMBL6310 |  |
Ki | = | 12.0 | nM | 202.26 | COc1ccc2c3c([nH]c2c1)CNCC3 | Homo sapiens | CHEMBL841867 | single protein format |
| CHEMBL60186 |  |
Ki | = | 13.0 | nM | 227.27 | c1cc2c3c(c1)ccn3CC(C1=NCCN1)O2 | Homo sapiens | CHEMBL874098 | single protein format |
| CHEMBL14242 |  |
Ki | = | 17.0 | nM | 235.26 | CN1CC(C2=NCCN2)Oc2ccc(F)cc21 | Homo sapiens | CHEMBL841871 | single protein format |
| CHEMBL300388 |  |
Ki | = | 17.0 | nM | 275.35 | CCOCc1ccc2c(c1)N(C)CC(C1=NCCN1)O2 | Homo sapiens | CHEMBL841871 | single protein format |
| CHEMBL3546379 |  |
Ki | = | 19.0 | nM | 214.31 | CC1CCC(Nc2cccc3c2CCC3)=N1 | Homo sapiens | CHEMBL3888188 | assay format |
| CHEMBL13987 |  |
Ki | = | 21.7 | nM | 231.3 | Cc1ccc2c(c1)N(C)CC(C1=NCCN1)O2 | Homo sapiens | CHEMBL874098 | single protein format |
| CHEMBL269538 |  |
Ki | = | 22.0 | nM | 212.25 | COc1ccc2c(c1)[nH]c1c(C)nccc12 | Homo sapiens | CHEMBL841867 | single protein format |
| CHEMBL13958 |  |
Ki | = | 22.7 | nM | 231.3 | Cc1cccc2c1OC(C1=NCCN1)CN2C | Homo sapiens | CHEMBL874098 | single protein format |
| CHEMBL1079 |  |
Ki | = | 28.3 | nM | 253.72 | Clc1ccc2nsnc2c1NC1=NCCN1 | Homo sapiens | CHEMBL989166 | assay format |
| CHEMBL420 |  |
Ki | = | 34.7 | nM | 231.09 | N=C(N)N/N=C/c1c(Cl)cccc1Cl | Homo sapiens | CHEMBL989166 | assay format |