Q9Y251 | HPSE_HUMAN | Heparanase (HPSE)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF03662 | Glyco_hydro_79n - Glycosyl hydrolase family 79, N-terminal domain | 165~370 |
3D structures mapped by conservation among orthologs
[ Domain: "Glycosyl hydrolase domain" // UNK_F_TYPE ]
[ Domain: "TIM barrels" // Glyco_hydro_39_1st ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL200597 |  |
IC50 | = | 75.0 | nM | 500.61 | Cc1cc2nc(-c3ccc(NC(=O)Nc4ccc(-c5nc6cc(C)c(C)cc6[nH]5)cc4)cc3)[nH]c2cc1C | Homo sapiens | CHEMBL869912 | assay format |
| CHEMBL372737 |  |
IC50 | = | 150.0 | nM | 472.55 | Cc1ccc2[nH]c(-c3ccc(NC(=O)Nc4ccc(-c5nc6cc(C)ccc6[nH]5)cc4)cc3)nc2c1 | Homo sapiens | CHEMBL869912 | assay format |
| CHEMBL199610 |  |
IC50 | = | 150.0 | nM | 458.53 | Cc1cccc2[nH]c(-c3ccc(NC(=O)Nc4ccc(-c5nc6ccccc6[nH]5)cc4)cc3)nc12 | Homo sapiens | CHEMBL869912 | assay format |
| CHEMBL200541 |  |
IC50 | = | 150.0 | nM | 472.55 | Cc1cccc2[nH]c(-c3ccc(NC(=O)Nc4ccc(-c5nc6c(C)cccc6[nH]5)cc4)cc3)nc12 | Homo sapiens | CHEMBL869912 | assay format |
| CHEMBL4576477 |  |
IC50 | = | 160.0 | nM | 545.41 | COc1ccc(C(=O)Nc2ccc(CNc3ccc(-c4nc5ccccc5[nH]4)cc3F)cc2)cc1Br | Homo sapiens | CHEMBL4326335 | single protein format |
| CHEMBL4283251 |  |
IC50 | = | 180.0 | nM | 598.52 | O=C(O)Cc1ccc2oc(-c3ccc(NC(=O)Nc4ccc(-c5nc6cc(CC(=O)O)ccc6o5)cc4F)c(F)c3)nc2c1 | Homo sapiens | CHEMBL4265450 | single protein format |
| CHEMBL2349247 |  |
IC50 | = | 200.0 | nM | 483.33 | CC(=O)Cc1ccc2oc(-c3ccc(/C=C/C(=O)Nc4ccc(Cl)c(Cl)c4)cc3F)nc2c1 | Homo sapiens | CHEMBL2349721 | assay format |
| CHEMBL326904 |  |
IC50 | = | 200.0 | nM | 534.48 | COc1ccc(N2C(=O)c3ccc(C(=O)O)cc3C2=O)cc1-c1nc2cc(-c3ccc4c(c3)OCO4)ccc2o1 | Homo sapiens | CHEMBL872937 | organism-based format |
| CHEMBL196746 |  |
IC50 | = | 200.0 | nM | 485.3 | O=C(O)Cc1ccc2oc(-c3ccc(/C=C/C(=O)Nc4ccc(Cl)cc4Cl)cc3F)nc2c1 | Homo sapiens | CHEMBL831099 | single protein format |
| CHEMBL5285151 |  |
IC50 | = | 200.0 | nM | 495.3 | O=C(O)Cc1ccc2oc(-c3ccc(NC(=O)/C=C/c4ccc(Br)cc4)cc3F)nc2c1 | Homo sapiens | CHEMBL5257690 | cell-based format |
| CHEMBL325614 |  |
IC50 | = | 200.0 | nM | 567.99 | COCCNc1ccc(N2C(=O)c3ccc(C(=O)O)cc3C2=O)cc1-c1nc2cc(-c3ccc(Cl)cc3)ccc2o1 | Homo sapiens | CHEMBL872937 | organism-based format |
| CHEMBL193591 |  |
IC50 | = | 200.0 | nM | 485.3 | O=C(O)Cc1ccc2oc(-c3ccc(/C=C/C(=O)Nc4ccc(Cl)c(Cl)c4)cc3F)nc2c1 | Homo sapiens | CHEMBL831099 | single protein format |
| CHEMBL193906 |  |
IC50 | = | 200.0 | nM | 551.99 | CCCNc1ccc(N2C(=O)c3ccc(C(=O)O)cc3C2=O)cc1-c1nc2cc(-c3ccc(Cl)cc3)ccc2o1 | Homo sapiens | CHEMBL831099 | single protein format |
| CHEMBL193625 |  |
IC50 | = | 200.0 | nM | 495.3 | O=C(O)Cc1ccc2oc(-c3ccc(/C=C/C(=O)Nc4cccc(Br)c4)cc3F)nc2c1 | Homo sapiens | CHEMBL831099 | single protein format |
| CHEMBL5277782 |  |
IC50 | = | 200.0 | nM | 536.52 | CCCOc1ccc(N2C(=O)c3ccc(C(=O)O)cc3C2=O)cc1-c1nc2cc(-c3ccc(F)cc3)ccc2o1 | Homo sapiens | CHEMBL5245674 | single protein format |
| CHEMBL200215 |  |
IC50 | = | 230.0 | nM | 527.42 | COc1ccc(C(=O)Nc2ccc(CNc3ccc(-c4nc5ccccc5[nH]4)cc3)cc2)cc1Br | Homo sapiens | CHEMBL868733 | assay format |
| CHEMBL5266599 |  |
IC50 | = | 230.0 | nM | 513.4 | COc1ccc(C(=O)Nc2ccc(Nc3ccc(-c4nc5ccccc5[nH]4)cc3)cc2)cc1Br | Homo sapiens | CHEMBL5245676 | single protein format |
| CHEMBL5271688 |  |
IC50 | = | 250.0 | nM | 561.55 | CCCNc1ccc(N2C(=O)c3ccc(C(=O)O)cc3C2=O)cc1-c1nc2cc(-c3ccc4c(c3)OCO4)ccc2o1 | Homo sapiens | CHEMBL5245674 | single protein format |
| CHEMBL109657 |  |
IC50 | = | 250.0 | nM | 517.54 | CCCNc1ccc(N2C(=O)c3ccc(C(=O)O)cc3C2=O)cc1-c1nc2cc(-c3ccccc3)ccc2o1 | Homo sapiens | CHEMBL872937 | organism-based format |
| CHEMBL380606 |  |
IC50 | = | 270.0 | nM | 444.5 | O=C(Nc1ccc(-c2nc3ccccc3[nH]2)cc1)Nc1ccc(-c2nc3ccccc3[nH]2)cc1 | Homo sapiens | CHEMBL869912 | assay format |