Q9Y239 | NOD1_HUMAN | Nucleotide-binding oligomerization domain-containing protein 1 (NOD1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00619 | CARD - Caspase recruitment domain | 21~98 | |
| PF05729 | NACHT - NACHT domain | 197~367 | |
| PF13516 | LRR_6 - Leucine Rich repeat | 730~749 | |
| PF13516 | LRR_6 - Leucine Rich repeat | 786~805 | |
| PF13516 | LRR_6 - Leucine Rich repeat | 821~833 | |
| PF13516 | LRR_6 - Leucine Rich repeat | 839~861 | |
| PF17776 | NLRC4_HD2 - NLRC4 helical domain HD2 | 517~666 | |
| PF17779 | NOD2_WH - NOD2 winged helix domain | 458~515 |
3D structures mapped by conservation among orthologs
[ Domain: "DEATH domain" // CARD ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1713298 |  |
IC50 | = | 80.0 | nM | 426.44 | O=C(Nc1ccc(OC(F)(F)F)cc1)c1ccc(CN2CCc3ccccc3C2)cc1 | Homo sapiens | CHEMBL2020290 | cell-based format |
| CHEMBL1521474 |  |
IC50 | = | 90.0 | nM | 307.76 | Nc1nc2ccccc2n1S(=O)(=O)c1ccc(Cl)cc1 | Homo sapiens | CHEMBL2020290 | cell-based format |
| CHEMBL1569174 |  |
IC50 | = | 150.0 | nM | 414.51 | CCOC(=O)c1ccc(NC(=O)c2ccc(CN3CCc4ccccc4C3)cc2)cc1 | Homo sapiens | CHEMBL2020290 | cell-based format |
| CHEMBL3321858 |  |
IC50 | = | 200.0 | nM | 502.62 | CN(CCc1nc2ccccc2n1CC(=O)Nc1ccc2c(c1)CCC2)C(=O)c1ccc2ccccc2c1 | Homo sapiens | CHEMBL3363923 | cell-based format |
| CHEMBL4779776 |  |
IC50 | = | 230.0 | nM | 493.51 | CCCCc1noc(CC2c3cccc(C)c3S(=O)(=O)N2C(=O)c2cccc(C(F)(F)F)c2)n1 | Homo sapiens | CHEMBL4773081 | cell-based format |
| CHEMBL1704728 |  |
IC50 | = | 240.0 | nM | 388.54 | CSc1ccc(NC(=O)c2ccc(CN3CCc4ccccc4C3)cc2)cc1 | Homo sapiens | CHEMBL2020290 | cell-based format |
| CHEMBL1732337 |  |
IC50 | = | 260.0 | nM | 470.55 | CC1Cc2cc(S(=O)(=O)N3CCN(c4ccc([N+](=O)[O-])cc4)CC3)ccc2N1C(=O)C1CC1 | Homo sapiens | CHEMBL2020290 | cell-based format |
| CHEMBL3321857 |  |
IC50 | = | 400.0 | nM | 452.56 | CN(CCc1nc2ccccc2n1CC(=O)Nc1ccc2c(c1)CCC2)C(=O)c1ccccc1 | Homo sapiens | CHEMBL3363923 | cell-based format |
| CHEMBL1450407 |  |
IC50 | = | 510.0 | nM | 455.58 | COc1ccc(N2CCN(S(=O)(=O)c3ccc4c(c3)CC(C)N4C(=O)C3CC3)CC2)cc1 | Homo sapiens | CHEMBL2020290 | cell-based format |
| CHEMBL1700405 |  |
IC50 | = | 510.0 | nM | 372.47 | COc1ccc(NC(=O)c2ccc(CN3CCc4ccccc4C3)cc2)cc1 | Homo sapiens | CHEMBL2020290 | cell-based format |
| CHEMBL1412853 |  |
IC50 | = | 560.0 | nM | 287.34 | Cc1ccc(S(=O)(=O)n2c(N)nc3ccccc32)cc1 | Homo sapiens | CHEMBL2020290 | cell-based format |
| CHEMBL4103835 |  |
IC50 | = | 610.0 | nM | 595.05 | COC(=O)CC[C@H]1NC(=O)c2cc(Oc3cccc(N(C)C)c3)c(NC(=O)COCc3ccc(Cl)cc3)cc2NC1=O | Homo sapiens | CHEMBL4016493 | cell-based format |
| CHEMBL1419822 |  |
IC50 | = | 790.0 | nM | 301.26 | Cn1c(=O)[nH]c(=O)c2c1nc([N+](=O)[O-])n2Cc1ccccc1 | Homo sapiens | CHEMBL3363923 | cell-based format |
| CHEMBL3321853 |  |
IC50 | = | 800.0 | nM | 440.55 | CC(C)c1cccc(NC(=O)Cn2c(CCNC(=O)c3ccccc3)nc3ccccc32)c1 | Homo sapiens | CHEMBL3363923 | cell-based format |
| CHEMBL1612423 |  |
IC50 | = | 830.0 | nM | 376.89 | O=C(Nc1ccc(Cl)cc1)c1ccc(CN2CCc3ccccc3C2)cc1 | Homo sapiens | CHEMBL2020290 | cell-based format |
| CHEMBL4750880 |  |
IC50 | = | 840.0 | nM | 501.89 | O=C(NCCCOc1ccc(C(F)(F)F)cc1)c1cc2nc[nH]c(=O)c2cc1-c1cccc(Cl)c1 | Homo sapiens | CHEMBL4710716 | cell-based format |
| CHEMBL4742329 |  |
IC50 | = | 890.0 | nM | 573.96 | COC(=O)Cn1cnc2cc(C(=O)NCCCOc3ccc(C(F)(F)F)cc3)c(-c3cccc(Cl)c3)cc2c1=O | Homo sapiens | CHEMBL4710716 | cell-based format |
| CHEMBL1595049 |  |
IC50 | = | 940.0 | nM | 372.49 | CCCCCn1c(SCCc2ccccc2)nc2c1c(=O)[nH]c(=O)n2C | Homo sapiens | CHEMBL3363923 | cell-based format |
| CHEMBL4757010 |  |
IC50 | = | 1000.0 | nM | 443.53 | CCc1ccc(S(=O)(=O)Nc2cc(-n3c(C)nc4ccccc4c3=O)ccc2F)s1 | Homo sapiens | CHEMBL4710741 | cell-based format |