Q9Y233 | PDE10_HUMAN | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00233 | PDEase_I - 3'5'-cyclic nucleotide phosphodiesterase | 790~1020 | |
| PF01590 | GAF - GAF domain | 371~504 | |
| PF01590 | GAF - GAF domain | 544~688 |
3D structures mapped by conservation among orthologs
[ Domain: "HD-domain/PDEase-like" // PDEase_I ]
- 2OUN
- 2OUP
- 2OUQ
- 2OUR
- 2OUS
- 2OUU
- 2OUV
- 2OUY
- 2WEY
- 2Y0J
- 3SN7
- 3SNI
- 3SNL
- 3UI7
- 3UUO
- 3WI2
- 3WS8
- 3WS9
- 3WYK
- 3WYL
- 3WYM
- 4AEL
- 4AJD
- 4AJF
- 4AJG
- 4AJM
- 4BBX
- 4DDL
- 4DFF
- 4FCB
- 4FCD
- 4HEU
- 4HF4
- 4LKQ
- 4LLJ
- 4LLK
- 4LLP
- 4LLX
- 4LM0
- 4LM1
- 4LM2
- 4LM3
- 4LM4
- 4MRW
- 4MRZ
- 4MS0
- 4MSA
- 4MSC
- 4MSE
- 4MSH
- 4MSN
- 4MUW
- 4MVH
- 4P0N
- 4P1R
- 4PHW
- 4TPM
- 4TPP
- 4WN1
- 4XY2
- 4YQH
- 4YS7
- 4ZO5
- 5AXP
- 5AXQ
- 5B4K
- 5B4L
- 5C1W
- 5C28
- 5C29
- 5C2A
- 5C2E
- 5C2H
- 5DH4
- 5DH5
- 5EDE
- 5EDG
- 5EDH
- 5EDI
- 5I2R
- 5K9R
- 5UWF
- 5XUI
- 5XUJ
- 5ZNL
- 6IJH
- 6IJI
- 6KDX
- 6KDZ
- 6KE0
- 6MSA
- 6MSC
[ Domain: "sensor domains" // GAF ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3686946 |  |
IC50 | = | 0.001 | nM | 372.47 | CC1(C)CC(c2nccnc2C2CN(c3ccc4ccccc4n3)C2)=CCO1 | Homo sapiens | CHEMBL3705852 | assay format |
| CHEMBL3686945 |  |
IC50 | = | 0.0011 | nM | 344.42 | C1=C(c2nccnc2C2CN(c3ccc4ccccc4n3)C2)CCOC1 | Homo sapiens | CHEMBL3705852 | assay format |
| CHEMBL3691541 |  |
IC50 | = | 0.0012 | nM | 369.43 | COc1cccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)n1 | Homo sapiens | CHEMBL3705852 | assay format |
| CHEMBL3691542 |  |
IC50 | = | 0.00122 | nM | 424.4 | Fc1cc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc(C(F)(F)F)c1 | Homo sapiens | CHEMBL3705852 | assay format |
| CHEMBL3686914 |  |
IC50 | = | 0.00135 | nM | 399.45 | COc1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)c(OC)n1 | Homo sapiens | CHEMBL3705852 | assay format |
| CHEMBL3686927 |  |
IC50 | = | 0.0023 | nM | 386.89 | Cc1cc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)ccc1Cl | Homo sapiens | CHEMBL3705852 | assay format |
| CHEMBL3686929 |  |
IC50 | = | 0.0023 | nM | 388.86 | Oc1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc1Cl | Homo sapiens | CHEMBL3705852 | assay format |
| CHEMBL3686909 |  |
IC50 | = | 0.00234 | nM | 369.43 | COc1ncccc1-c1nccnc1C1CN(c2ccc3ccccc3n2)C1 | Homo sapiens | CHEMBL3705852 | assay format |
| CHEMBL3686919 |  |
IC50 | = | 0.00262 | nM | 416.51 | CS(=O)(=O)c1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc1 | Homo sapiens | CHEMBL3705852 | assay format |
| CHEMBL3686920 |  |
IC50 | = | 0.00278 | nM | 354.42 | Nc1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cn1 | Homo sapiens | CHEMBL3705852 | assay format |
| CHEMBL3686910 |  |
IC50 | = | 0.00279 | nM | 353.43 | Cc1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cn1 | Homo sapiens | CHEMBL3705852 | assay format |
| CHEMBL2180441 |  |
IC50 | = | 0.0033 | nM | 518.57 | Cc1nc2ccc(C(F)(F)F)cc2nc1/C=C/c1nc(N[C@@H]2CCS(=O)(=O)C2)cc(N2CCCC2)n1 | Homo sapiens | CHEMBL2187842 | single protein format |
| CHEMBL3686933 |  |
IC50 | = | 0.0035 | nM | 382.47 | COc1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc1C | Homo sapiens | CHEMBL3705852 | assay format |
| CHEMBL3686921 |  |
IC50 | = | 0.00376 | nM | 354.42 | Nc1cncc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)c1 | Homo sapiens | CHEMBL3705852 | assay format |
| CHEMBL3686936 |  |
IC50 | = | 0.0041 | nM | 390.85 | Fc1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc1Cl | Homo sapiens | CHEMBL3705852 | assay format |
| CHEMBL3686912 |  |
IC50 | = | 0.00418 | nM | 357.39 | Fc1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cn1 | Homo sapiens | CHEMBL3705852 | assay format |
| CHEMBL3686928 |  |
IC50 | = | 0.0042 | nM | 370.43 | Cc1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc1F | Homo sapiens | CHEMBL3705852 | assay format |
| CHEMBL3686935 |  |
IC50 | = | 0.0051 | nM | 370.43 | Cc1cc(F)cc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)c1 | Homo sapiens | CHEMBL3705852 | assay format |
| CHEMBL3686939 |  |
IC50 | = | 0.0055 | nM | 366.47 | Cc1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc1C | Homo sapiens | CHEMBL3705852 | assay format |
| CHEMBL3686931 |  |
IC50 | = | 0.0062 | nM | 400.46 | CCOc1ccc(-c2nccnc2C2CN(c3ccc4ccccc4n3)C2)cc1F | Homo sapiens | CHEMBL3705852 | assay format |