Q9Y210 | TRPC6_HUMAN | Short transient receptor potential channel 6 (TRPC6)

Pfam Domain Table

AccessionDomainRangeColor
PF00520Ion_trans - Ion transport protein486~738
PF08344TRP_2 - Transient receptor ion channel II253~315
PF12796Ank_2 - Ankyrin repeats (3 copies)104~183

3D structures mapped by conservation among orthologs


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL4764496 IC50 = 0.1 nM 375.4 Cc1ccc(Cn2c(N3CC[C@@H](F)[C@H](N)C3)nc3cc(F)c(F)cc32)nc1 Homo sapiens CHEMBL4725099 cell-based format
CHEMBL4741505 IC50 = 0.2 nM 362.36 N[C@@H]1CN(c2nc3ccc(F)cc3n2Cc2ncc(F)cn2)CC[C@H]1F Homo sapiens CHEMBL4725099 cell-based format
CHEMBL4752852 IC50 = 0.3 nM 395.82 N[C@@H]1CN(c2nc3cc(F)ccc3n2Cc2ccc(Cl)cn2)CCC1(F)F Homo sapiens CHEMBL4725099 cell-based format
CHEMBL4776935 IC50 = 0.4 nM 408.84 COc1cc(F)c2nc(N3CC[C@@H](F)[C@H](N)C3)n(Cc3ncc(Cl)cn3)c2c1 Homo sapiens CHEMBL4725099 cell-based format
CHEMBL4746182 IC50 = 0.4 nM 361.37 N[C@@H]1CN(c2nc3ccc(F)cc3n2Cc2ccc(F)cn2)CC[C@H]1F Homo sapiens CHEMBL4725099 cell-based format
CHEMBL4753871 IC50 = 0.4 nM 362.36 N[C@@H]1CN(c2nc3cc(F)ccc3n2Cc2ncc(F)cn2)CC[C@H]1F Homo sapiens CHEMBL4725099 cell-based format
CHEMBL4129456 IC50 = 3.0 nM 369.48 C[C@]12CCC(F)=C[C@H]1C[C@@H](N1CCC[C@@H](N)C1)[C@@H]2Oc1ccc(C#N)cc1 Homo sapiens CHEMBL4122824 cell-based format
CHEMBL2418809 IC50 = 4.0 nM 411.89 CC1CCCN(C(=O)c2nc(Nc3cc4c(cc3F)OCO4)sc2Cl)C1C Homo sapiens CHEMBL2422303 cell-based format
CHEMBL4129805 IC50 = 8.0 nM 365.48 N#Cc1ccc(O[C@@H]2[C@@H]3[C@H](C[C@H]2N2CCC[C@@H](N)C2)[C@@H]2CC(=O)[C@H]3C2)cc1 Homo sapiens CHEMBL4122824 cell-based format
CHEMBL4129809 IC50 = 9.5 nM 367.88 N#Cc1ccc(O[C@@H]2c3ccccc3C[C@H]2N2CCC[C@@H](N)C2)c(Cl)c1 Homo sapiens CHEMBL4122824 cell-based format
CHEMBL4127600 IC50 = 11.0 nM 367.49 C[C@]12CCC(=O)C[C@H]1C[C@@H](N1CCC[C@@H](N)C1)[C@@H]2Oc1ccc(C#N)cc1 Homo sapiens CHEMBL4122824 cell-based format
CHEMBL2418807 IC50 = 16.0 nM 359.45 CC1CCCN(C(=O)c2csc(Nc3ccc4c(c3)OCO4)n2)C1C Homo sapiens CHEMBL2422303 cell-based format
CHEMBL2418811 IC50 = 16.0 nM 381.9 Cc1sc(Nc2ccc(Cl)cc2F)nc1C(=O)N1CCC[C@H](C)[C@@H]1C Homo sapiens CHEMBL2422303 cell-based format
CHEMBL4126041 IC50 = 22.0 nM 339.44 N#Cc1ccc(O[C@@H]2[C@@H]3CCC(=O)[C@@H]3C[C@H]2N2CCC[C@@H](N)C2)cc1 Homo sapiens CHEMBL4122824 cell-based format
CHEMBL2418808 IC50 = 25.0 nM 391.47 Cc1sc(Nc2cc3c(cc2F)OCO3)nc1C(=O)N1CCCC(C)C1C Homo sapiens CHEMBL2422303 cell-based format
CHEMBL4128079 IC50 = 30.0 nM 389.49 C[C@]12CCC(F)(F)C[C@H]1C[C@@H](N1CCC[C@@H](N)C1)[C@@H]2Oc1ccc(C#N)cc1 Homo sapiens CHEMBL4122824 cell-based format
CHEMBL2418815 IC50 = 32.0 nM 407.5 Cc1sc(Nc2ccc3c(c2)OCO3)nc1C(=O)N1CCc2ccccc2C1C Homo sapiens CHEMBL2422303 cell-based format
CHEMBL4128782 IC50 = 33.0 nM 396.54 CO/N=C1\CC[C@@]2(C)[C@@H](C1)C[C@@H](N1CCC[C@@H](N)C1)[C@@H]2Oc1ccc(C#N)cc1 Homo sapiens CHEMBL4122824 cell-based format
CHEMBL4127190 IC50 = 37.0 nM 353.51 C[C@]12CCCC[C@H]1C[C@@H](N1CCC[C@@H](N)C1)[C@@H]2Oc1ccc(C#N)cc1 Homo sapiens CHEMBL4122824 cell-based format
CHEMBL4125756 IC50 = 49.0 nM 369.51 C[C@]12CC[C@@H](O)C[C@H]1C[C@@H](N1CCC[C@@H](N)C1)[C@@H]2Oc1ccc(C#N)cc1 Homo sapiens CHEMBL4122824 cell-based format