Q9Y210 | TRPC6_HUMAN | Short transient receptor potential channel 6 (TRPC6)
Pfam Domain Table
Accession | Domain | Range | Color |
---|---|---|---|
PF00520 | Ion_trans - Ion transport protein | 486~738 | |
PF08344 | TRP_2 - Transient receptor ion channel II | 253~315 | |
PF12796 | Ank_2 - Ankyrin repeats (3 copies) | 104~183 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
---|---|---|---|---|---|---|---|---|---|---|
CHEMBL4764496 | IC50 | = | 0.1 | nM | 375.4 | Cc1ccc(Cn2c(N3CC[C@@H](F)[C@H](N)C3)nc3cc(F)c(F)cc32)nc1 | Homo sapiens | CHEMBL4725099 | cell-based format | |
CHEMBL4741505 | IC50 | = | 0.2 | nM | 362.36 | N[C@@H]1CN(c2nc3ccc(F)cc3n2Cc2ncc(F)cn2)CC[C@H]1F | Homo sapiens | CHEMBL4725099 | cell-based format | |
CHEMBL4752852 | IC50 | = | 0.3 | nM | 395.82 | N[C@@H]1CN(c2nc3cc(F)ccc3n2Cc2ccc(Cl)cn2)CCC1(F)F | Homo sapiens | CHEMBL4725099 | cell-based format | |
CHEMBL4776935 | IC50 | = | 0.4 | nM | 408.84 | COc1cc(F)c2nc(N3CC[C@@H](F)[C@H](N)C3)n(Cc3ncc(Cl)cn3)c2c1 | Homo sapiens | CHEMBL4725099 | cell-based format | |
CHEMBL4746182 | IC50 | = | 0.4 | nM | 361.37 | N[C@@H]1CN(c2nc3ccc(F)cc3n2Cc2ccc(F)cn2)CC[C@H]1F | Homo sapiens | CHEMBL4725099 | cell-based format | |
CHEMBL4753871 | IC50 | = | 0.4 | nM | 362.36 | N[C@@H]1CN(c2nc3cc(F)ccc3n2Cc2ncc(F)cn2)CC[C@H]1F | Homo sapiens | CHEMBL4725099 | cell-based format | |
CHEMBL4129456 | IC50 | = | 3.0 | nM | 369.48 | C[C@]12CCC(F)=C[C@H]1C[C@@H](N1CCC[C@@H](N)C1)[C@@H]2Oc1ccc(C#N)cc1 | Homo sapiens | CHEMBL4122824 | cell-based format | |
CHEMBL2418809 | IC50 | = | 4.0 | nM | 411.89 | CC1CCCN(C(=O)c2nc(Nc3cc4c(cc3F)OCO4)sc2Cl)C1C | Homo sapiens | CHEMBL2422303 | cell-based format | |
CHEMBL4129805 | IC50 | = | 8.0 | nM | 365.48 | N#Cc1ccc(O[C@@H]2[C@@H]3[C@H](C[C@H]2N2CCC[C@@H](N)C2)[C@@H]2CC(=O)[C@H]3C2)cc1 | Homo sapiens | CHEMBL4122824 | cell-based format | |
CHEMBL4129809 | IC50 | = | 9.5 | nM | 367.88 | N#Cc1ccc(O[C@@H]2c3ccccc3C[C@H]2N2CCC[C@@H](N)C2)c(Cl)c1 | Homo sapiens | CHEMBL4122824 | cell-based format | |
CHEMBL4127600 | IC50 | = | 11.0 | nM | 367.49 | C[C@]12CCC(=O)C[C@H]1C[C@@H](N1CCC[C@@H](N)C1)[C@@H]2Oc1ccc(C#N)cc1 | Homo sapiens | CHEMBL4122824 | cell-based format | |
CHEMBL2418807 | IC50 | = | 16.0 | nM | 359.45 | CC1CCCN(C(=O)c2csc(Nc3ccc4c(c3)OCO4)n2)C1C | Homo sapiens | CHEMBL2422303 | cell-based format | |
CHEMBL2418811 | IC50 | = | 16.0 | nM | 381.9 | Cc1sc(Nc2ccc(Cl)cc2F)nc1C(=O)N1CCC[C@H](C)[C@@H]1C | Homo sapiens | CHEMBL2422303 | cell-based format | |
CHEMBL4126041 | IC50 | = | 22.0 | nM | 339.44 | N#Cc1ccc(O[C@@H]2[C@@H]3CCC(=O)[C@@H]3C[C@H]2N2CCC[C@@H](N)C2)cc1 | Homo sapiens | CHEMBL4122824 | cell-based format | |
CHEMBL2418808 | IC50 | = | 25.0 | nM | 391.47 | Cc1sc(Nc2cc3c(cc2F)OCO3)nc1C(=O)N1CCCC(C)C1C | Homo sapiens | CHEMBL2422303 | cell-based format | |
CHEMBL4128079 | IC50 | = | 30.0 | nM | 389.49 | C[C@]12CCC(F)(F)C[C@H]1C[C@@H](N1CCC[C@@H](N)C1)[C@@H]2Oc1ccc(C#N)cc1 | Homo sapiens | CHEMBL4122824 | cell-based format | |
CHEMBL2418815 | IC50 | = | 32.0 | nM | 407.5 | Cc1sc(Nc2ccc3c(c2)OCO3)nc1C(=O)N1CCc2ccccc2C1C | Homo sapiens | CHEMBL2422303 | cell-based format | |
CHEMBL4128782 | IC50 | = | 33.0 | nM | 396.54 | CO/N=C1\CC[C@@]2(C)[C@@H](C1)C[C@@H](N1CCC[C@@H](N)C1)[C@@H]2Oc1ccc(C#N)cc1 | Homo sapiens | CHEMBL4122824 | cell-based format | |
CHEMBL4127190 | IC50 | = | 37.0 | nM | 353.51 | C[C@]12CCCC[C@H]1C[C@@H](N1CCC[C@@H](N)C1)[C@@H]2Oc1ccc(C#N)cc1 | Homo sapiens | CHEMBL4122824 | cell-based format | |
CHEMBL4125756 | IC50 | = | 49.0 | nM | 369.51 | C[C@]12CC[C@@H](O)C[C@H]1C[C@@H](N1CCC[C@@H](N)C1)[C@@H]2Oc1ccc(C#N)cc1 | Homo sapiens | CHEMBL4122824 | cell-based format |