Q9UQL6 | HDAC5_HUMAN | Histone deacetylase 5 (HDAC5)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00850 | Hist_deacetyl - Histone deacetylase domain | 704~1022 | |
| PF12203 | HDAC4_Gln - Glutamine rich N terminal domain of histone deacetylase 4 | 67~164 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3692689 |  |
IC50 | = | 1.2 | nM | 418.42 | C[C@H](CN(C)Cc1ccccc1)NC(=O)c1ccc(-c2noc(C(F)(F)F)n2)cc1 | Homo sapiens | CHEMBL5156168 | single protein format |
| CHEMBL2312164 |  |
IC50 | = | 2.31 | nM | 280.32 | Cc1cccc(C(=O)NOCCCCCC(=O)NO)c1 | Homo sapiens | CHEMBL2318995 | single protein format |
| CHEMBL2414098 |  |
IC50 | = | 2.5 | nM | 340.22 | O=C(CCCCCCc1nc2ccc(Br)cc2[nH]1)NO | Homo sapiens | CHEMBL2417301 | single protein format |
| CHEMBL3110021 |  |
IC50 | = | 4.0 | nM | 320.35 | O=C(NO)[C@@H]1[C@H](c2ccccc2)[C@H]1c1ccc(-c2cnco2)cc1 | Homo sapiens | CHEMBL3112173 | single protein format |
| CHEMBL2312168 |  |
IC50 | = | 4.22 | nM | 294.35 | Cc1cc(C)cc(C(=O)NOCCCCCC(=O)NO)c1 | Homo sapiens | CHEMBL2318995 | single protein format |
| CHEMBL2105763 |  |
IC50 | = | 5.95 | nM | 394.48 | Cn1cc(CNCC2CCN(c3ncc(C(=O)NO)cn3)CC2)c2ccccc21 | Homo sapiens | CHEMBL4376740 | cell-based format |
| CHEMBL3110001 |  |
IC50 | = | 7.0 | nM | 305.34 | O=C(NO)[C@@H]1[C@H](c2ccccc2)[C@H]1c1ccc2nccnc2c1 | Homo sapiens | CHEMBL3112173 | single protein format |
| CHEMBL609583 |  |
IC50 | = | 7.1 | nM | 413.46 | O=C(NO)c1cnc(N2CCN(S(=O)(=O)c3ccc4ccccc4c3)CC2)nc1 | Homo sapiens | CHEMBL1068532 | single protein format |
| CHEMBL484073 |  |
IC50 | = | 7.6 | nM | 327.38 | O=C(/C=C/c1ccc2cccnc2c1)NCCCCCC(=O)NO | Homo sapiens | CHEMBL960368 | single protein format |
| CHEMBL4761013 |  |
IC50 | = | 8.0 | nM | 408.44 | O=C(NO)c1ccc(CN2C(=O)c3ccccc3S2(=O)=O)cc1-c1ccccc1 | Homo sapiens | CHEMBL4737691 | single protein format |
| CHEMBL3109983 |  |
IC50 | = | 9.0 | nM | 390.36 | O=C(NO)[C@@H]1[C@H](c2ccccc2)[C@H]1c1ccc2c(c1)CN(CC(F)(F)F)C2=O | Homo sapiens | CHEMBL3112173 | single protein format |
| CHEMBL3109980 |  |
IC50 | = | 9.0 | nM | 345.78 | O=C(NO)[C@@H]1[C@H](c2ccccc2)[C@H]1c1cc(Cl)c2c(c1)OCCO2 | Homo sapiens | CHEMBL3112173 | single protein format |
| CHEMBL3793392 |  |
IC50 | = | 10.0 | nM | 367.36 | O=C(NO)[C@]1(F)[C@H](c2ccccc2)[C@H]1c1ccc(-c2ncc(F)cn2)cc1 | Homo sapiens | CHEMBL3796509 | single protein format |
| CHEMBL518821 |  |
IC50 | = | 10.0 | nM | 422.34 | O=C(c1ccc(-c2nc(COc3ccc(-c4nnco4)cc3)no2)s1)C(F)(F)F | Homo sapiens | CHEMBL3112173 | single protein format |
| CHEMBL3692671 |  |
IC50 | = | 10.0 | nM | 398.43 | CCCN(CCC)C[C@@H](C)NC(=O)c1ccc(-c2noc(C(F)(F)F)n2)cc1 | Homo sapiens | CHEMBL4689588 | single protein format |
| CHEMBL487253 |  |
IC50 | = | 10.0 | nM | 358.27 | Cn1c(CCCC(=O)O)nc2cc(N(CCCl)CCCl)ccc21 | Homo sapiens | CHEMBL5113667 | single protein format |
| CHEMBL598797 |  |
IC50 | = | 11.4 | nM | 434.5 | C#Cc1cccc(Nc2ncnc3cc(OC)c(OCCCCCCC(=O)NO)cc23)c1 | Homo sapiens | CHEMBL1065585 | assay format |
| CHEMBL4748500 |  |
IC50 | = | 12.0 | nM | 372.38 | O=C(NO)c1ccc(CN2C(=O)c3ccccc3C2=O)cc1-c1ccccc1 | Homo sapiens | CHEMBL4737691 | single protein format |
| CHEMBL4437833 |  |
IC50 | = | 16.0 | nM | 337.35 | Cc1ncc(-c2ccc(C(C(=O)NO)c3ccccc3F)cc2)cn1 | Homo sapiens | CHEMBL4310908 | cell-based format |
| CHEMBL4799406 |  |
IC50 | = | 16.0 | nM | 390.37 | O=C(NO)c1ccc(CN2C(=O)c3cccc(F)c3C2=O)cc1-c1ccccc1 | Homo sapiens | CHEMBL4737691 | single protein format |