Q9UQD0 | SCN8A_HUMAN | Sodium channel protein type 8 subunit alpha (SCN8A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00520 | Ion_trans - Ion transport protein | 131~420 | |
| PF00520 | Ion_trans - Ion transport protein | 753~983 | |
| PF00520 | Ion_trans - Ion transport protein | 1197~1473 | |
| PF00520 | Ion_trans - Ion transport protein | 1522~1776 | |
| PF06512 | Na_trans_assoc - Sodium ion transport-associated | 991~1192 | |
| PF11933 | Na_trans_cytopl - Cytoplasmic domain of voltage-gated Na+ ion channel | 546~702 | |
| PF24609 | IQ_SCN5A_C - SCN5A-like, C-terminal IQ motif | 1888~1913 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3617063 |  |
IC50 | = | 0.8 | nM | 534.96 | Nc1nc2cc(-c3cc(Cl)ccc3Oc3cc(F)c(S(=O)(=O)Nc4ncns4)cc3F)ccc2[nH]1 | Homo sapiens | CHEMBL3806747 | cell-based format |
| CHEMBL501134 |  |
IC50 | = | 1.1 | nM | 299.29 | N=C1N[C@H]2[C@H](COC(N)=O)NC(=N)N3CCC(O)(O)[C@]23N1 | Homo sapiens | CHEMBL4321996 | cell-based format |
| CHEMBL5182397 |  |
IC50 | = | 1.2 | nM | 431.24 | O=C1C[C@H](C(=O)NC(c2ccc(Cl)cc2)c2ccc(Cl)c(C(F)(F)F)c2)CN1 | Homo sapiens | CHEMBL5135965 | cell-based format |
| CHEMBL507974 |  |
IC50 | = | 2.3 | nM | 319.27 | NC1=N[C@H](O)[C@H]2[C@H]3O[C@]4(O)O[C@@H]([C@@H](O)[C@@]2(N1)[C@@H]4O)[C@]3(O)CO | Homo sapiens | CHEMBL4321996 | cell-based format |
| CHEMBL5196342 |  |
IC50 | = | 2.6 | nM | 414.79 | O=C1C[C@H](C(=O)NC(c2ccc(Cl)cc2)c2ccc(F)c(C(F)(F)F)c2)CN1 | Homo sapiens | CHEMBL5135965 | cell-based format |
| CHEMBL5193659 |  |
IC50 | = | 2.9 | nM | 433.76 | O=C1C[C@H](C(=O)NC(c2ccc(F)c(Cl)c2)c2ccc(F)c(C(F)(F)F)n2)CN1 | Homo sapiens | CHEMBL5135965 | cell-based format |
| CHEMBL5194703 |  |
IC50 | = | 3.4 | nM | 381.23 | O=C1C[C@H](C(=O)NC(c2ccc(Cl)cc2)c2ccc(F)c(Cl)c2)CN1 | Homo sapiens | CHEMBL5135965 | cell-based format |
| CHEMBL5183619 |  |
IC50 | = | 4.1 | nM | 412.8 | O=C1C[C@H](C(=O)NC(c2ccc(Cl)cc2)c2ccc(OC(F)(F)F)cc2)CN1 | Homo sapiens | CHEMBL5135965 | cell-based format |
| CHEMBL5197040 |  |
IC50 | = | 4.2 | nM | 468.21 | O=C1C[C@H](C(=O)NC(c2cnc(C(F)(F)F)c(Cl)c2)c2ccc(F)c(Cl)c2F)CN1 | Homo sapiens | CHEMBL5135965 | cell-based format |
| CHEMBL3341983 |  |
IC50 | = | 11.0 | nM | 535.94 | Nc1noc2ccc(-c3cc(Cl)ccc3Oc3cc(F)c(S(=O)(=O)Nc4ncns4)cc3F)cc12 | Homo sapiens | CHEMBL3806747 | cell-based format |
| CHEMBL3662190 |  |
IC50 | = | 38.0 | nM | 435.56 | CC1(COc2cc(F)c(C(=O)NS(=O)(=O)C3CC3)cc2C2CC2)CCC2(CC1)CC2 | Homo sapiens | CHEMBL4321996 | cell-based format |
| CHEMBL3662077 |  |
IC50 | = | 49.0 | nM | 445.5 | CC1(COc2cc(F)c(C(=O)NS(=O)(=O)C3CC3)cc2C2CC2)CCC(F)(F)CC1 | Homo sapiens | CHEMBL5264217 | cell-based format |
| CHEMBL5424289 |  |
IC50 | = | 51.0 | nM | 460.6 | Cc1cc(S(=O)(=O)Nc2cscn2)c(F)cc1N(C)[C@@H]1CCN(Cc2ccccc2)C1 | Homo sapiens | CHEMBL5384401 | cell-based format |
| CHEMBL5196338 |  |
IC50 | = | 80.0 | nM | 373.46 | N#Cc1ccc(Oc2ccc3c(ccc(=O)n3CCN3CCCCC3)c2)cc1 | Homo sapiens | CHEMBL5147705 | assay format |
| CHEMBL4290579 |  |
IC50 | = | 92.0 | nM | 442.59 | O=S(=O)(Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(C3CC3)cn12)C1CC1 | Homo sapiens | CHEMBL4256592 | cell-based format |
| CHEMBL2325014 |  |
IC50 | = | 160.0 | nM | 500.36 | Nc1[nH]ncc1-c1cc(Cl)ccc1Oc1cc(F)c(S(=O)(=O)Nc2cscn2)cc1Cl | Homo sapiens | CHEMBL4321996 | cell-based format |
| CHEMBL3707218 |  |
IC50 | = | 170.0 | nM | 429.35 | O=C1N(Cc2ccc(C(F)(F)F)o2)c2ccccc2[C@]12COc1cc3c(cc12)OCO3 | Homo sapiens | CHEMBL4321996 | cell-based format |
| CHEMBL4279238 |  |
IC50 | = | 190.0 | nM | 416.55 | CS(=O)(=O)Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(C3CC3)cn12 | Homo sapiens | CHEMBL4256592 | cell-based format |
| CHEMBL5094715 |  |
IC50 | = | 198.0 | nM | 543.49 | C[C@@H](c1cc(Cl)cc(Cl)c1)N1CCC(COc2cc(F)c(C(=O)NS(C)(=O)=O)cc2C2CC2)CC1 | Homo sapiens | CHEMBL5055702 | cell-based format |
| CHEMBL4854735 |  |
IC50 | = | 230.0 | nM | 581.49 | O=S(=O)(Nc1cccc(F)n1)c1cc(F)c(O[C@H]2CCN(CC(F)(F)F)C[C@@H]2c2ccc(F)c(F)c2)c(F)c1 | Homo sapiens | CHEMBL4813116 | single protein format |