Q9UPP1 | PHF8_HUMAN | Histone lysine demethylase PHF8 (PHF8)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00628 | PHD - PHD-finger | 44~89 | |
| PF02373 | JmjC - JmjC domain, hydroxylase | 270~370 | |
| PF17811 | JHD - Jumonji helical domain | 374~477 |
3D structures mapped by conservation among orthologs
[ Domain: "Double-stranded beta-helix" // JmjC_1 ]
[ Domain: "C-terminal helical domain in Jumonji domain-containing histone demethylases" // KOG1633 ]
[ Domain: "FYVE/PHD zinc finger" // PHD ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4294926 |  |
IC50 | = | 100.0 | nM | 336.79 | Clc1ccccc1Cn1cnc(-c2cc(-c3c[nH]nn3)ccn2)c1 | Homo sapiens | CHEMBL4257000 | cell-based format |
| CHEMBL4281254 |  |
IC50 | = | 100.0 | nM | 226.24 | Cn1cnc(-c2cc(-c3c[nH]nn3)ccn2)c1 | Homo sapiens | CHEMBL4257000 | cell-based format |
| CHEMBL4283877 |  |
IC50 | = | 100.0 | nM | 316.37 | CC(c1ccccc1)n1cnc(-c2cc(-c3c[nH]nn3)ccn2)c1 | Homo sapiens | CHEMBL4257000 | cell-based format |
| CHEMBL4281520 |  |
IC50 | = | 100.0 | nM | 320.33 | Cn1cnc(-c2cc(-c3c[nH]nn3)ccn2)c1-c1ccc(F)cc1 | Homo sapiens | CHEMBL4257000 | cell-based format |
| CHEMBL4279714 |  |
IC50 | = | 100.0 | nM | 346.39 | COc1ccccc1CCn1cnc(-c2cc(-c3c[nH]nn3)ccn2)c1 | Homo sapiens | CHEMBL4257000 | cell-based format |
| CHEMBL4279343 |  |
IC50 | = | 100.0 | nM | 414.39 | FC(F)(F)COc1ccccc1CCn1cnc(-c2cc(-c3c[nH]nn3)ccn2)c1 | Homo sapiens | CHEMBL4257000 | cell-based format |
| CHEMBL4294188 |  |
IC50 | = | 100.0 | nM | 360.42 | CCOc1ccccc1CCn1cnc(-c2cc(-c3c[nH]nn3)ccn2)c1 | Homo sapiens | CHEMBL4257000 | cell-based format |
| CHEMBL4280770 |  |
IC50 | = | 100.0 | nM | 356.43 | c1ccc2c(c1)CCCC2Cn1cnc(-c2cc(-c3c[nH]nn3)ccn2)c1 | Homo sapiens | CHEMBL4257000 | cell-based format |
| CHEMBL4278569 |  |
IC50 | = | 100.0 | nM | 391.44 | N#Cc1[nH]nnc1-c1ccnc(-c2cn(CCc3cccc4ccccc34)cn2)c1 | Homo sapiens | CHEMBL4257000 | cell-based format |
| CHEMBL4279599 |  |
IC50 | = | 100.0 | nM | 381.44 | N#Cc1[nH]nnc1-c1ccnc(-c2cn(CC3CCCc4ccccc43)cn2)c1 | Homo sapiens | CHEMBL4257000 | cell-based format |
| CHEMBL4292796 |  |
IC50 | = | 100.0 | nM | 386.46 | c1ccc(OCC2CC2)c(CCn2cnc(-c3cc(-c4c[nH]nn4)ccn3)c2)c1 | Homo sapiens | CHEMBL4257000 | cell-based format |
| CHEMBL4282591 |  |
IC50 | = | 100.0 | nM | 366.43 | c1ccc2c(CCn3cnc(-c4cc(-c5c[nH]nn5)ccn4)c3)cccc2c1 | Homo sapiens | CHEMBL4257000 | cell-based format |
| CHEMBL4288588 |  |
IC50 | = | 100.0 | nM | 371.23 | Clc1cccc(Cn2cnc(-c3cc(-c4c[nH]nn4)ccn3)c2)c1Cl | Homo sapiens | CHEMBL4257000 | cell-based format |
| CHEMBL4287550 |  |
IC50 | = | 100.0 | nM | 404.78 | FC(F)(F)c1cccc(Cn2cnc(-c3cc(-c4c[nH]nn4)ccn3)c2)c1Cl | Homo sapiens | CHEMBL4257000 | cell-based format |
| CHEMBL4292673 |  |
IC50 | = | 100.0 | nM | 497.13 | Clc1cccc(Cn2cnc(-c3cc(-c4nn[nH]c4I)ccn3)c2)c1Cl | Homo sapiens | CHEMBL4257000 | cell-based format |
| CHEMBL4288982 |  |
IC50 | = | 100.0 | nM | 389.22 | Fc1[nH]nnc1-c1ccnc(-c2cn(Cc3cccc(Cl)c3Cl)cn2)c1 | Homo sapiens | CHEMBL4257000 | cell-based format |
| CHEMBL4283711 |  |
IC50 | = | 100.0 | nM | 384.37 | FC(F)(F)c1ccccc1CCn1cnc(-c2cc(-c3c[nH]nn3)ccn2)c1 | Homo sapiens | CHEMBL4257000 | cell-based format |
| CHEMBL4283694 |  |
IC50 | = | 100.0 | nM | 350.36 | COc1cccc(Cn2cnc(-c3cc(-c4c[nH]nn4)ccn3)c2)c1F | Homo sapiens | CHEMBL4257000 | cell-based format |
| CHEMBL4287368 |  |
IC50 | = | 100.0 | nM | 378.87 | CC(C)(Cn1cnc(-c2cc(-c3c[nH]nn3)ccn2)c1)c1ccccc1Cl | Homo sapiens | CHEMBL4257000 | cell-based format |
| CHEMBL4293177 |  |
IC50 | = | 100.0 | nM | 334.36 | Cc1cccc(Cn2cnc(-c3cc(-c4c[nH]nn4)ccn3)c2)c1F | Homo sapiens | CHEMBL4257000 | cell-based format |