Q9UPN9 | TRI33_HUMAN | E3 ubiquitin-protein ligase TRIM33 (TRIM33)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00439 | Bromodomain - Bromodomain | 966~1050 | |
| PF00628 | PHD - PHD-finger | 890~931 | |
| PF00643 | zf-B_box - B-box zinc finger | 274~310 |
3D structures mapped by conservation among orthologs
[ Domain: "Bromodomain" // Bromodomain ]
[ Domain: "FYVE/PHD zinc finger" // PHD_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4440737 |  |
IC50 | = | 3.19 | nM | 319.37 | COc1ccc(Nc2c(-c3c[nH]c(C)n3)nc3ccccn23)cc1 | Homo sapiens | CHEMBL4418855 | single protein format |
| CHEMBL4470967 |  |
IC50 | = | 13.72 | nM | 398.26 | COc1ccc(Nc2c(-c3nc[nH]c3C)nc3ccc(Br)cn23)cc1 | Homo sapiens | CHEMBL4418855 | single protein format |
| CHEMBL18620 |  |
IC50 | = | 233.5 | nM | 84.12 | O=C1CCCC1 | Homo sapiens | CHEMBL4418855 | single protein format |
| CHEMBL4467793 |  |
IC50 | = | 240.3 | nM | 159.19 | Cc1cccc2c(C=O)c[nH]c12 | Homo sapiens | CHEMBL4418855 | single protein format |
| CHEMBL18737 |  |
IC50 | = | 249.8 | nM | 126.2 | O=C1CCCCCCC1 | Homo sapiens | CHEMBL4418855 | single protein format |
| CHEMBL4572394 |  |
IC50 | = | 268.9 | nM | 175.23 | O=Cc1ccc(N2CCCC2)cc1 | Homo sapiens | CHEMBL4418855 | single protein format |
| CHEMBL543846 |  |
IC50 | = | 283.4 | nM | 203.62 | Cc1ncc(CO)c(C=O)c1O.Cl | Homo sapiens | CHEMBL4418855 | single protein format |
| CHEMBL108925 |  |
IC50 | = | 299.4 | nM | 122.12 | O=Cc1ccccc1O | Homo sapiens | CHEMBL4418855 | single protein format |
| CHEMBL350966 |  |
IC50 | = | 300.6 | nM | 152.15 | COc1ccc(C=O)c(O)c1 | Homo sapiens | CHEMBL4418855 | single protein format |
| CHEMBL2229659 |  |
IC50 | = | 305.4 | nM | 109.13 | Cn1cccc1C=O | Homo sapiens | CHEMBL4418855 | single protein format |
| CHEMBL4451080 |  |
IC50 | = | 319.8 | nM | 550.64 | COC(=O)c1ccc2nc(-c3cn(S(=O)(=O)c4ccc(C)cc4)c4ccccc34)c(NCc3ccccc3)n2c1 | Homo sapiens | CHEMBL4418855 | single protein format |
| CHEMBL13883 |  |
IC50 | = | 325.6 | nM | 152.15 | COc1cc(C=O)ccc1O | Homo sapiens | CHEMBL4418855 | single protein format |
| CHEMBL4592980 |  |
IC50 | = | 335.7 | nM | 226.23 | O=Cc1cccc(-c2ccc(C(=O)O)cc2)c1 | Homo sapiens | CHEMBL4418855 | single protein format |
| CHEMBL4448530 |  |
IC50 | = | 537.9 | nM | 398.26 | COc1ccc(Nc2c(-c3c[nH]c(C)n3)nc3ccc(Br)cn23)cc1 | Homo sapiens | CHEMBL4418855 | single protein format |
| CHEMBL4452179 |  |
IC50 | = | 553.2 | nM | 566.68 | COc1ccc(CCNc2c(-c3cn(S(=O)(=O)c4ccc(C)cc4)c4ccccc34)nc3ccccn23)cc1OC | Homo sapiens | CHEMBL4418855 | single protein format |
| CHEMBL4446283 |  |
IC50 | = | 641.0 | nM | 319.37 | COc1ccc(Nc2c(-c3nc[nH]c3C)nc3ccccn23)cc1 | Homo sapiens | CHEMBL4418855 | single protein format |