Q9UNA0 | ATS5_HUMAN | A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5)

Pfam Domain Table

AccessionDomainRangeColor
PF00090TSP_1 - Thrombospondin type 1 domain572~621
PF01421Reprolysin - Reprolysin (M12B) family zinc metalloprotease269~476
PF05986ADAMTS_spacer1 - ADAM-TS Spacer 1734~852
PF17771ADAMTS_CR_2 - ADAMTS cysteine-rich domain 2487~554
PF19030TSP1_ADAMTS - Thrombospondin type 1 domain879~930
PF19236ADAMTS_CR_3 - ADAMTS cysteine-rich domain628~731

3D structures mapped by conservation among orthologs

[ Domain: "Metalloproteases ("zincins") catalytic domain" // Reprolysin ]

 PyMOL session

[ Domain: "Disulfide-rich domain in A Disintegrin And Metalloprotease (ADAM) domain-containing proteins" // KOG3538_1st ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL4066965 IC50 = 1.0 nM 383.37 C[C@H](Cc1ccc(C(F)(F)F)cc1)C(=O)NC[C@@]1(C2CC2)NC(=O)NC1=O Homo sapiens CHEMBL3887658 single protein format
CHEMBL179552 IC50 = 1.4 nM 503.4 CC1(C)C[C@@H](O)CN(S(=O)(=O)c2ccc(OCc3ccc(Cl)cc3Cl)cc2)[C@H]1C(=O)NO Homo sapiens CHEMBL1768098 single protein format
CHEMBL4072836 IC50 = 2.0 nM 397.4 CC[C@H](Cc1ccc(C(F)(F)F)cc1)C(=O)NC[C@@]1(C2CC2)NC(=O)NC1=O Homo sapiens CHEMBL3887658 single protein format
CHEMBL3980860 IC50 = 2.0 nM 409.41 O=C1NC(=O)[C@](CNC(=O)[C@@H](Cc2ccc(C(F)(F)F)cc2)C2CC2)(C2CC2)N1 Homo sapiens CHEMBL3887658 single protein format
CHEMBL1766903 IC50 = 2.9 nM 460.96 C[C@@H]1[C@H](c2ccccc2)[C@]1(NS(=O)(=O)c1cc2[nH]c3cc(Cl)ccc3c2s1)C(=O)O Homo sapiens CHEMBL1768098 single protein format
CHEMBL4436740 IC50 = 3.0 nM 435.36 Cc1cnc([C@]2(CNC(=O)c3cc4cc(C(F)(F)F)ccc4o3)NC(=O)NC2=O)n1C Homo sapiens CHEMBL4425557 single protein format
CHEMBL3972836 IC50 = 4.0 nM 397.4 CC(C)(Cc1ccc(C(F)(F)F)cc1)C(=O)NC[C@@]1(C2CC2)NC(=O)NC1=O Homo sapiens CHEMBL3887658 single protein format
CHEMBL4450729 IC50 = 4.0 nM 435.36 CCn1ccnc1[C@]1(CNC(=O)c2cc3cc(C(F)(F)F)ccc3o2)NC(=O)NC1=O Homo sapiens CHEMBL4425557 single protein format
CHEMBL3358158 IC50 = 4.0 nM 421.34 Cn1ccnc1[C@]1(CNC(=O)c2cc3cc(C(F)(F)F)ccc3o2)NC(=O)NC1=O Homo sapiens CHEMBL3388951 single protein format
CHEMBL4097165 IC50 = 5.0 nM 381.31 O=C1NC(=O)[C@](CNC(=O)c2cc3cc(C(F)(F)F)ccc3o2)(C2CC2)N1 Homo sapiens CHEMBL4425557 single protein format
CHEMBL4102193 IC50 = 5.0 nM 369.34 O=C(CCc1ccc(C(F)(F)F)cc1)NC[C@@]1(C2CC2)NC(=O)NC1=O Homo sapiens CHEMBL4013265 single protein format
CHEMBL187092 IC50 = 6.3 nM 472.92 C[C@@]1(O)CCCN(S(=O)(=O)c2ccc(OCc3ccc(F)cc3Cl)cc2)[C@H]1C(=O)NO Homo sapiens CHEMBL2167992 cell-based format
CHEMBL4587825 IC50 = 7.0 nM 401.81 Cc1cnc([C@]2(CNC(=O)c3cc4cc(Cl)ccc4o3)NC(=O)NC2=O)n1C Homo sapiens CHEMBL4425557 single protein format
CHEMBL1078281 IC50 = 7.4 nM 437.93 C[C@@H]1[C@H](c2ccccc2)[C@]1(NS(=O)(=O)c1ccc(-n2cc(Cl)cn2)s1)C(=O)O Homo sapiens CHEMBL1106705 single protein format
CHEMBL4864283 IC50 = 8.0 nM 458.52 CC1[C@](C)(c2ccccc2)[C@]1(NS(=O)(=O)N1CCc2c(nc3cc(F)ccn23)C1)C(=O)O Homo sapiens CHEMBL4835255 single protein format
CHEMBL3955404 IC50 = 8.0 nM 411.42 CC(C)[C@H](Cc1ccc(C(F)(F)F)cc1)C(=O)NC[C@@]1(C2CC2)NC(=O)NC1=O Homo sapiens CHEMBL3887658 single protein format
CHEMBL1766904 IC50 = 8.3 nM 444.51 C[C@@H]1[C@H](c2ccccc2)[C@]1(NS(=O)(=O)c1cc2[nH]c3cc(F)ccc3c2s1)C(=O)O Homo sapiens CHEMBL1768098 single protein format
CHEMBL1767014 IC50 = 8.4 nM 458.52 C[C@@H]1[C@](C)(c2ccccc2)[C@]1(NS(=O)(=O)N1CCc2c(nc3cc(F)ccn23)C1)C(=O)O Homo sapiens CHEMBL1768098 single protein format
CHEMBL1767011 IC50 = 8.6 nM 444.49 C[C@@H]1[C@H](c2ccccc2)[C@]1(NS(=O)(=O)N1CCc2c(nn3cc(F)ccc23)C1)C(=O)O Homo sapiens CHEMBL1768098 single protein format
CHEMBL4589438 IC50 = 9.0 nM 401.81 CCn1ccnc1[C@]1(CNC(=O)c2cc3cc(Cl)ccc3o2)NC(=O)NC1=O Homo sapiens CHEMBL4425557 single protein format