Q9UM47 | NOTC3_HUMAN | Neurogenic locus notch homolog protein 3 (NOTCH3)

Pfam Domain Table

AccessionDomainRangeColor
PF00008EGF - EGF-like domain43~75
PF00008EGF - EGF-like domain123~153
PF00008EGF - EGF-like domain201~231
PF00008EGF - EGF-like domain318~346
PF00008EGF - EGF-like domain355~385
PF00008EGF - EGF-like domain435~464
PF00008EGF - EGF-like domain511~539
PF00008EGF - EGF-like domain549~577
PF00008EGF - EGF-like domain586~615
PF00008EGF - EGF-like domain775~806
PF00008EGF - EGF-like domain853~883
PF00008EGF - EGF-like domain1004~1031
PF00008EGF - EGF-like domain1055~1080
PF00008EGF - EGF-like domain1088~1118
PF00008EGF - EGF-like domain1126~1151
PF00008EGF - EGF-like domain1172~1201
PF00008EGF - EGF-like domain1339~1371
PF00023Ank - Ankyrin repeat1905~1936
PF00066Notch - LNR domain1385~1418
PF00066Notch - LNR domain1425~1458
PF00066Notch - LNR domain1465~1500
PF06816NOD - NOTCH protein1505~1559
PF07645EGF_CA - Calcium-binding EGF domain158~190
PF07645EGF_CA - Calcium-binding EGF domain274~307
PF07645EGF_CA - Calcium-binding EGF domain391~424
PF07645EGF_CA - Calcium-binding EGF domain810~842
PF07645EGF_CA - Calcium-binding EGF domain1205~1239
PF07684NODP - NOTCH protein1577~1637
PF12661hEGF - Human growth factor-like EGF245~266
PF12661hEGF - Human growth factor-like EGF478~499
PF12661hEGF - Human growth factor-like EGF632~649
PF12661hEGF - Human growth factor-like EGF666~686
PF12661hEGF - Human growth factor-like EGF704~724
PF12661hEGF - Human growth factor-like EGF896~916
PF12661hEGF - Human growth factor-like EGF933~954
PF12796Ank_2 - Ankyrin repeats (3 copies)1819~1900
PF12796Ank_2 - Ankyrin repeats (3 copies)1957~2024

3D structures mapped by conservation among orthologs

[ Domain: "Notch heterodimerization domain" // NOD ]

 PyMOL session

[ Domain: "Lin12/Notch repeat" // Notch ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL3410162 IC50 = 1.0 nM 550.58 Cc1cccc([C@H](C(N)=O)[C@@H](CCC(F)(F)F)C(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 Homo sapiens CHEMBL3412051 cell-based format
CHEMBL3410169 IC50 = 1.0 nM 572.53 CN1C(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2ccc(F)cc2F)N=C(c2ccccc2)c2ccccc21 Homo sapiens CHEMBL3412051 cell-based format
CHEMBL3410167 IC50 = 1.0 nM 554.54 CN1C(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2ccc(F)cc2)N=C(c2ccccc2)c2ccccc21 Homo sapiens CHEMBL3412051 cell-based format
CHEMBL3410153 IC50 = 1.0 nM 530.59 CCC(CC)[C@H](C(N)=O)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O Homo sapiens CHEMBL3412051 cell-based format
CHEMBL3410168 IC50 = 2.0 nM 572.53 CN1C(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2ccc(F)c(F)c2)N=C(c2ccccc2)c2ccccc21 Homo sapiens CHEMBL3412051 cell-based format
CHEMBL3410170 IC50 = 2.0 nM 572.53 CN1C(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2cc(F)cc(F)c2)N=C(c2ccccc2)c2ccccc21 Homo sapiens CHEMBL3412051 cell-based format
CHEMBL3922868 IC50 = 2.1 nM 582.55 NC(=O)[C@@H](CCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(C3CC3)c2NC1=O Homo sapiens CHEMBL3888077 single protein format
CHEMBL3410160 IC50 = 3.0 nM 541.53 Cc1nocc1[C@H](C(N)=O)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O Homo sapiens CHEMBL3412051 cell-based format
CHEMBL3410151 IC50 = 3.0 nM 490.65 CCC(CC)[C@H](C(N)=O)[C@@H](CC(C)C)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O Homo sapiens CHEMBL3412051 cell-based format
CHEMBL3410152 IC50 = 3.0 nM 504.68 CCC(CC)[C@H](C(N)=O)[C@@H](CC(C)(C)C)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O Homo sapiens CHEMBL3412051 cell-based format
CHEMBL3971963 IC50 = 3.0 nM 556.51 Cc1ccc(C2=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc3ccccc32)cc1 Homo sapiens CHEMBL3888077 single protein format
CHEMBL3984723 IC50 = 3.2 nM 598.59 Cc1cccc(C2=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc3c2cccc3C(C)C)c1 Homo sapiens CHEMBL3888077 single protein format
CHEMBL3985392 IC50 = 4.0 nM 598.54 NC(=O)[C@@H](CCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(OC3CC3)c2NC1=O Homo sapiens CHEMBL3888077 single protein format
CHEMBL3410161 IC50 = 4.0 nM 536.55 CN1C(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2ccccc2)N=C(c2ccccc2)c2ccccc21 Homo sapiens CHEMBL3412051 cell-based format
CHEMBL3960841 IC50 = 4.2 nM 572.51 NC(=O)[C@@H](CCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccc(CO)cc2)c2ccccc2NC1=O Homo sapiens CHEMBL3888077 single protein format
CHEMBL3891599 IC50 = 4.4 nM 590.95 Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1cccc(Cl)c1 Homo sapiens CHEMBL3888077 single protein format
CHEMBL3985584 IC50 = 4.5 nM 584.56 CCc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1cccc(C)c1 Homo sapiens CHEMBL3888077 single protein format
CHEMBL3984170 IC50 = 4.6 nM 556.51 Cc1ccccc1C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc2ccccc21 Homo sapiens CHEMBL3888077 single protein format
CHEMBL3983707 IC50 = 4.9 nM 584.56 CC(C)c1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1ccccc1 Homo sapiens CHEMBL3888077 single protein format
CHEMBL3895390 IC50 = 5.7 nM 586.53 COc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1cccc(C)c1 Homo sapiens CHEMBL3888077 single protein format