Q9UM47 | NOTC3_HUMAN | Neurogenic locus notch homolog protein 3 (NOTCH3)
Helixβ‑strandTurn secondary structure
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00008 | EGF | 43–75 | |
| PF00008 | EGF | 123–153 | |
| PF00008 | EGF | 201–231 | |
| PF00008 | EGF | 318–346 | |
| PF00008 | EGF | 355–385 | |
| PF00008 | EGF | 435–464 | |
| PF00008 | EGF | 511–539 | |
| PF00008 | EGF | 549–577 | |
| PF00008 | EGF | 586–615 | |
| PF00008 | EGF | 775–806 | |
| PF00008 | EGF | 853–883 | |
| PF00008 | EGF | 1004–1031 | |
| PF00008 | EGF | 1055–1080 | |
| PF00008 | EGF | 1088–1118 | |
| PF00008 | EGF | 1126–1151 | |
| PF00008 | EGF | 1172–1201 | |
| PF00008 | EGF | 1339–1371 | |
| PF00023 | Ank | 1905–1936 | |
| PF00066 | Notch | 1385–1418 | |
| PF00066 | Notch | 1425–1458 | |
| PF00066 | Notch | 1465–1500 | |
| PF06816 | NOD | 1505–1559 | |
| PF07645 | EGF_CA | 158–190 | |
| PF07645 | EGF_CA | 274–307 | |
| PF07645 | EGF_CA | 391–424 | |
| PF07645 | EGF_CA | 810–842 | |
| PF07645 | EGF_CA | 1205–1239 | |
| PF07684 | NODP | 1577–1637 | |
| PF12661 | hEGF | 245–266 | |
| PF12661 | hEGF | 478–499 | |
| PF12661 | hEGF | 632–649 | |
| PF12661 | hEGF | 666–686 | |
| PF12661 | hEGF | 704–724 | |
| PF12661 | hEGF | 896–916 | |
| PF12661 | hEGF | 933–954 | |
| PF12796 | Ank_2 | 1819–1900 | |
| PF12796 | Ank_2 | 1957–2024 |
3D structures mapped by conservation among orthologs
[ Domain: "Notch heterodimerization domain" // NOD ]
[ Domain: "Lin12/Notch repeat" // Notch ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3410162 |  |
IC50 | = | 1.0 | nM | 550.58 | Cc1cccc([C@H](C(N)=O)[C@@H](CCC(F)(F)F)C(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | Homo sapiens | CHEMBL3412051 | cell-based format |
| CHEMBL3410169 |  |
IC50 | = | 1.0 | nM | 572.53 | CN1C(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2ccc(F)cc2F)N=C(c2ccccc2)c2ccccc21 | Homo sapiens | CHEMBL3412051 | cell-based format |
| CHEMBL3410167 |  |
IC50 | = | 1.0 | nM | 554.54 | CN1C(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2ccc(F)cc2)N=C(c2ccccc2)c2ccccc21 | Homo sapiens | CHEMBL3412051 | cell-based format |
| CHEMBL3410153 |  |
IC50 | = | 1.0 | nM | 530.59 | CCC(CC)[C@H](C(N)=O)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O | Homo sapiens | CHEMBL3412051 | cell-based format |
| CHEMBL3410168 |  |
IC50 | = | 2.0 | nM | 572.53 | CN1C(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2ccc(F)c(F)c2)N=C(c2ccccc2)c2ccccc21 | Homo sapiens | CHEMBL3412051 | cell-based format |
| CHEMBL3410170 |  |
IC50 | = | 2.0 | nM | 572.53 | CN1C(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2cc(F)cc(F)c2)N=C(c2ccccc2)c2ccccc21 | Homo sapiens | CHEMBL3412051 | cell-based format |
| CHEMBL3922868 |  |
IC50 | = | 2.1 | nM | 582.55 | NC(=O)[C@@H](CCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(C3CC3)c2NC1=O | Homo sapiens | CHEMBL3888077 | single protein format |
| CHEMBL3410160 |  |
IC50 | = | 3.0 | nM | 541.53 | Cc1nocc1[C@H](C(N)=O)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O | Homo sapiens | CHEMBL3412051 | cell-based format |
| CHEMBL3410151 |  |
IC50 | = | 3.0 | nM | 490.65 | CCC(CC)[C@H](C(N)=O)[C@@H](CC(C)C)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O | Homo sapiens | CHEMBL3412051 | cell-based format |
| CHEMBL3410152 |  |
IC50 | = | 3.0 | nM | 504.68 | CCC(CC)[C@H](C(N)=O)[C@@H](CC(C)(C)C)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O | Homo sapiens | CHEMBL3412051 | cell-based format |
| CHEMBL3971963 |  |
IC50 | = | 3.0 | nM | 556.51 | Cc1ccc(C2=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc3ccccc32)cc1 | Homo sapiens | CHEMBL3888077 | single protein format |
| CHEMBL3984723 |  |
IC50 | = | 3.2 | nM | 598.59 | Cc1cccc(C2=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc3c2cccc3C(C)C)c1 | Homo sapiens | CHEMBL3888077 | single protein format |
| CHEMBL3985392 |  |
IC50 | = | 4.0 | nM | 598.54 | NC(=O)[C@@H](CCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(OC3CC3)c2NC1=O | Homo sapiens | CHEMBL3888077 | single protein format |
| CHEMBL3410161 |  |
IC50 | = | 4.0 | nM | 536.55 | CN1C(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2ccccc2)N=C(c2ccccc2)c2ccccc21 | Homo sapiens | CHEMBL3412051 | cell-based format |
| CHEMBL3960841 |  |
IC50 | = | 4.2 | nM | 572.51 | NC(=O)[C@@H](CCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccc(CO)cc2)c2ccccc2NC1=O | Homo sapiens | CHEMBL3888077 | single protein format |
| CHEMBL3891599 |  |
IC50 | = | 4.4 | nM | 590.95 | Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1cccc(Cl)c1 | Homo sapiens | CHEMBL3888077 | single protein format |
| CHEMBL3985584 |  |
IC50 | = | 4.5 | nM | 584.56 | CCc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1cccc(C)c1 | Homo sapiens | CHEMBL3888077 | single protein format |
| CHEMBL3984170 |  |
IC50 | = | 4.6 | nM | 556.51 | Cc1ccccc1C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc2ccccc21 | Homo sapiens | CHEMBL3888077 | single protein format |
| CHEMBL3983707 |  |
IC50 | = | 4.9 | nM | 584.56 | CC(C)c1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1ccccc1 | Homo sapiens | CHEMBL3888077 | single protein format |
| CHEMBL3895390 |  |
IC50 | = | 5.7 | nM | 586.53 | COc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1cccc(C)c1 | Homo sapiens | CHEMBL3888077 | single protein format |