Q9UM07 | PADI4_HUMAN | Protein-arginine deiminase type-4 (PADI4)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF03068 | PAD - Protein-arginine deiminase (PAD) | 284~660 | |
| PF08526 | PAD_N - Protein-arginine deiminase (PAD) N-terminal domain | 1~111 | |
| PF08527 | PAD_M - Protein-arginine deiminase (PAD) middle domain | 113~273 |
3D structures mapped by conservation among orthologs
[ Domain: "Common fold of diphtheria toxin/transcription factors/cytochrome f" // PAD_M ]
[ Domain: "Cupredoxin-related" // PAD_N ]
[ Domain: "Pentein" // PAD ]
[ Domain: "Pentein" // PAD,PAD_M ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5437488 |  |
IC50 | <= | 10.0 | nM | 556.65 | Cn1c(-c2cc3cccc(OCCc4ccn[nH]4)c3n2CC2CC2)nc2cc3c(nc21)CCN(C[C@H](N)CF)C3=O | Homo sapiens | CHEMBL5346484 | single protein format |
| CHEMBL5395995 |  |
IC50 | <= | 10.0 | nM | 557.63 | Cn1c(-c2cc3cccc(OCCc4ccon4)c3n2CC2CC2)nc2cc3c(nc21)CCN(C[C@H](N)CF)C3=O | Homo sapiens | CHEMBL5346484 | single protein format |
| CHEMBL5438633 |  |
IC50 | <= | 10.0 | nM | 557.63 | Cn1c(-c2cc3cccc(OCCc4cnn[nH]4)c3n2CC2CC2)nc2cc3c(nc21)CCN(C[C@H](N)CF)C3=O | Homo sapiens | CHEMBL5346484 | single protein format |
| CHEMBL5419109 |  |
IC50 | <= | 10.0 | nM | 567.67 | Cn1c(-c2cc3cccc(OCCc4cccnc4)c3n2CC2CC2)nc2cc3c(nc21)CCN(C[C@H](N)CF)C3=O | Homo sapiens | CHEMBL5346484 | single protein format |
| CHEMBL5433085 |  |
IC50 | <= | 10.0 | nM | 557.63 | Cn1c(-c2cc3cccc(OCCc4cnco4)c3n2CC2CC2)nc2cc3c(nc21)CCN(C[C@H](N)CF)C3=O | Homo sapiens | CHEMBL5346484 | single protein format |
| CHEMBL5415549 |  |
IC50 | <= | 10.0 | nM | 557.63 | Cn1c(-c2cc3cccc(OCCn4cnnn4)c3n2CC2CC2)nc2cc3c(cc21)CCN(CC(N)CF)C3=O | Homo sapiens | CHEMBL5360347 | single protein format |
| CHEMBL5435488 |  |
IC50 | <= | 10.0 | nM | 556.65 | Cn1c(-c2cc3cccc(OCCn4cncn4)c3n2CC2CC2)nc2cc3c(cc21)CCN(CC(N)CF)C3=O | Homo sapiens | CHEMBL5360347 | single protein format |
| CHEMBL5425563 |  |
IC50 | <= | 10.0 | nM | 557.63 | Cn1c(-c2cc3ccnc(OCCn4ccnc4)c3n2CC2CC2)nc2cc3c(nc21)CCN(C[C@H](N)CF)C3=O | Homo sapiens | CHEMBL5346484 | single protein format |
| CHEMBL5427267 |  |
IC50 | <= | 10.0 | nM | 555.66 | Cn1c(-c2cc3cccc(OCCn4ccnc4)c3n2CC2CC2)nc2cc3c(cc21)CCN(CC(N)CF)C3=O | Homo sapiens | CHEMBL5360347 | single protein format |
| CHEMBL5428512 |  |
IC50 | <= | 10.0 | nM | 560.63 | Cn1c(-c2cc3cccc(OCC4CNC(=O)O4)c3n2CC2CC2)nc2cc3c(cc21)CCN(CC(N)CF)C3=O | Homo sapiens | CHEMBL5360347 | single protein format |
| CHEMBL5438281 |  |
IC50 | <= | 10.0 | nM | 556.64 | Cn1c(-c2cc3cccc(OCCc4cnoc4)c3n2CC2CC2)nc2cc3c(cc21)CCN(CC(N)CF)C3=O | Homo sapiens | CHEMBL5360347 | single protein format |
| CHEMBL5396801 |  |
IC50 | <= | 10.0 | nM | 576.67 | COC(=O)N(C)CCOc1cccc2cc(-c3nc4cc5c(cc4n3C)CCN(CC(N)CF)C5=O)n(CC3CC3)c12 | Homo sapiens | CHEMBL5360347 | single protein format |
| CHEMBL5180282 |  |
IC50 | = | 14.1 | nM | 583.69 | COc1cc(C(=O)N2[C@H]3CC[C@@H]2[C@H](N)C3)cc2nc(-c3cc4ccc([C@@H](C)N5CCOC5=O)nc4n3CC3CC3)c(C)n12 | Homo sapiens | CHEMBL5131025 | cell-based format |
| CHEMBL5081624 |  |
IC50 | = | 50.0 | nM | 510.04 | COc1cc(C(=O)N2CC[C@@H](O)[C@@H](N)C2)cc2nc(-c3cc4ccccc4n3CC3CC3)n(C)c12.Cl | Homo sapiens | CHEMBL5446172 | single protein format |
| CHEMBL4539512 |  |
IC50 | = | 50.0 | nM | 473.58 | COc1cc(C(=O)N2CC[C@@H](O)[C@@H](N)C2)cc2nc(-c3cc4ccccc4n3CC3CC3)n(C)c12 | Homo sapiens | CHEMBL4425347 | single protein format |
| CHEMBL5434057 |  |
IC50 | = | 200.0 | nM | 418.5 | COc1cc(C(=O)N2CCC[C@@H](N)C2)cc2cc(-c3cc4cccnc4n3C)n(N)c12 | Homo sapiens | CHEMBL5388666 | assay format |
| CHEMBL58150 |  |
IC50 | = | 240.0 | nM | 295.25 | NC1=CC(=O)c2ccc(-c3cccc(C(=O)O)n3)nc2C1=O | Homo sapiens | CHEMBL3119092 | single protein format |
| CHEMBL5071309 |  |
IC50 | = | 250.0 | nM | 435.96 | CCn1c(-c2nc3cc(C(=O)N4CC[C]C(N)C4)ccc3n2C)cc2ccccc21.Cl | Homo sapiens | CHEMBL5476572 | single protein format |
| CHEMBL1910970 |  |
IC50 | = | 400.0 | nM | 452.36 | N=C(CF)NCCC[C@H](NC(=O)c1ccccc1C(=O)O)C(N)=O.O=C(O)C(F)(F)F | Homo sapiens | CHEMBL1914114 | assay format |
| CHEMBL3113470 |  |
IC50 | = | 560.0 | nM | 253.06 | NC1=C(Br)C(=O)c2cccnc2C1=O | Homo sapiens | CHEMBL3119092 | single protein format |