Q9ULD8 | KCNH3_HUMAN | Potassium voltage-gated channel subfamily H member 3 (KCNH3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00027 | cNMP_binding - Cyclic nucleotide-binding domain | 604~647 | |
| PF00520 | Ion_trans - Ion transport protein | 226~511 | |
| PF13426 | PAS_9 - PAS domain | 40~135 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3987187 |  |
IC50 | = | 47.0 | nM | 412.86 | Cl.Fc1ccc(Nc2nc(NCc3ccco3)nc(Nc3ccccc3)n2)cc1 | Homo sapiens | CHEMBL3879996 | cell-based format |
| CHEMBL3902034 |  |
IC50 | = | 52.0 | nM | 358.41 | c1ccc(Nc2nc(NCc3ccco3)nc(Nc3ccccc3)n2)cc1 | Homo sapiens | CHEMBL3879996 | cell-based format |
| CHEMBL3960526 |  |
IC50 | = | 58.0 | nM | 406.4 | Fc1ccc(Nc2nc(NCc3ccncn3)nc(Nc3ccc(F)cc3)n2)cc1 | Homo sapiens | CHEMBL3880086 | cell-based format |
| CHEMBL3908982 |  |
IC50 | = | 65.0 | nM | 406.4 | Fc1ccc(Nc2nc(NCc3ncccn3)nc(Nc3ccc(F)cc3)n2)cc1 | Homo sapiens | CHEMBL3880086 | cell-based format |
| CHEMBL3918973 |  |
IC50 | = | 73.0 | nM | 430.85 | Cl.Fc1ccc(Nc2nc(NCc3ccco3)nc(Nc3ccc(F)cc3)n2)cc1 | Homo sapiens | CHEMBL3879996 | cell-based format |
| CHEMBL3979641 |  |
IC50 | = | 77.0 | nM | 388.41 | Fc1ccc(Nc2nc(NCc3ncccn3)nc(Nc3ccccc3)n2)cc1 | Homo sapiens | CHEMBL3880086 | cell-based format |
| CHEMBL3913727 |  |
IC50 | = | 79.0 | nM | 423.88 | Cl.Fc1cnccc1CNc1nc(Nc2ccccc2)nc(Nc2ccccc2)n1 | Homo sapiens | CHEMBL3879996 | cell-based format |
| CHEMBL3916475 |  |
IC50 | = | 84.0 | nM | 369.43 | c1ccc(Nc2nc(NCc3ccncc3)nc(Nc3ccccc3)n2)cc1 | Homo sapiens | CHEMBL3879996 | cell-based format |
| CHEMBL3934480 |  |
IC50 | = | 85.0 | nM | 441.87 | Cl.Fc1ccc(Nc2nc(NCc3ccnc(F)c3)nc(Nc3ccccc3)n2)cc1 | Homo sapiens | CHEMBL3879996 | cell-based format |
| CHEMBL3912592 |  |
IC50 | = | 85.0 | nM | 441.87 | Cl.Nc1nc(Nc2ccc(F)cc2)nc(N(Cc2ccnc(F)c2)c2ccccc2)n1 | Homo sapiens | CHEMBL3880086 | cell-based format |
| CHEMBL3918716 |  |
IC50 | = | 92.0 | nM | 418.44 | COc1ccc(Nc2nc(NCc3ncccn3)nc(Nc3ccc(F)cc3)n2)cc1 | Homo sapiens | CHEMBL3880086 | cell-based format |
| CHEMBL3941694 |  |
IC50 | = | 100.0 | nM | 459.86 | Cl.Fc1ccc(Nc2nc(NCc3ccnc(F)c3)nc(Nc3ccc(F)cc3)n2)cc1 | Homo sapiens | CHEMBL3879996 | cell-based format |
| CHEMBL3908600 |  |
IC50 | = | 110.0 | nM | 404.88 | Cl.OCCCCNc1nc(Nc2ccccc2)nc(Nc2ccc(F)cc2)n1 | Homo sapiens | CHEMBL3879996 | cell-based format |
| CHEMBL3930654 |  |
IC50 | = | 110.0 | nM | 478.33 | Cl.Cl.Fc1ccc(Nc2nc(NCc3ccncc3)nc(Nc3ccc(F)cc3)n2)cc1 | Homo sapiens | CHEMBL3879996 | cell-based format |
| CHEMBL3967925 |  |
IC50 | = | 140.0 | nM | 424.86 | CC(C)Nc1nc(Nc2ccccc2)nc(Nc2ccc(C(F)(F)F)cc2)n1.Cl | Homo sapiens | CHEMBL3879996 | cell-based format |
| CHEMBL3905763 |  |
IC50 | = | 140.0 | nM | 418.9 | Cl.OCCCCCNc1nc(Nc2ccccc2)nc(Nc2ccc(F)cc2)n1 | Homo sapiens | CHEMBL3879996 | cell-based format |
| CHEMBL3896688 |  |
IC50 | = | 170.0 | nM | 471.9 | COc1ccc(Nc2nc(NCc3ccnc(F)c3)nc(Nc3ccc(F)cc3)n2)cc1.Cl | Homo sapiens | CHEMBL3879996 | cell-based format |
| CHEMBL3965780 |  |
IC50 | = | 180.0 | nM | 438.87 | Cl.OCCOCCNc1nc(Nc2ccc(F)cc2)nc(Nc2ccc(F)cc2)n1 | Homo sapiens | CHEMBL3879996 | cell-based format |
| CHEMBL3951510 |  |
IC50 | = | 180.0 | nM | 320.4 | CC(C)Nc1nc(Nc2ccccc2)nc(Nc2ccccc2)n1 | Homo sapiens | CHEMBL3879996 | cell-based format |
| CHEMBL3899865 |  |
IC50 | = | 190.0 | nM | 364.45 | OCCCCCNc1nc(Nc2ccccc2)nc(Nc2ccccc2)n1 | Homo sapiens | CHEMBL3879996 | cell-based format |