Q9ULD4 | BRPF3_HUMAN | Bromodomain and PHD finger-containing protein 3 (BRPF3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00439 | Bromodomain - Bromodomain | 599~679 | |
| PF00855 | PWWP - PWWP domain | 1078~1184 | |
| PF10513 | EPL1 - Enhancer of polycomb-like | 48~194 | |
| PF13831 | PHD_2 - PHD-finger | 227~259 | |
| PF13832 | zf-HC5HC2H_2 - PHD-zinc-finger like domain | 268~386 |
3D structures mapped by conservation among orthologs
[ Domain: "SH3" // PWWP ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3752151 |  |
IC50 | = | 140.0 | nM | 383.43 | COc1cc(C#N)ccc1S(=O)(=O)Nc1ccc2c(c1)cc(C)c(=O)n2C | Homo sapiens | CHEMBL4030909 | assay format |
| CHEMBL4103077 |  |
IC50 | = | 190.0 | nM | 413.46 | COc1cc2c(cc1NS(=O)(=O)c1ccc(C#N)cc1OC)cc(C)c(=O)n2C | Homo sapiens | CHEMBL4030909 | assay format |
| CHEMBL4102050 |  |
IC50 | = | 260.0 | nM | 353.4 | Cc1cc2cc(NS(=O)(=O)c3ccc(C#N)cc3)ccc2n(C)c1=O | Homo sapiens | CHEMBL4030909 | assay format |
| CHEMBL4059962 |  |
IC50 | = | 280.0 | nM | 383.43 | COc1cc2c(cc1NS(=O)(=O)c1ccc(C#N)cc1)cc(C)c(=O)n2C | Homo sapiens | CHEMBL4030909 | assay format |
| CHEMBL4087315 |  |
IC50 | = | 590.0 | nM | 358.42 | COc1cc2c(cc1NS(=O)(=O)c1ccccc1)cc(C)c(=O)n2C | Homo sapiens | CHEMBL4030909 | assay format |
| CHEMBL4076056 |  |
IC50 | = | 1000.0 | nM | 339.38 | Cn1c(=O)ccc2cc(NS(=O)(=O)c3ccc(C#N)cc3)ccc21 | Homo sapiens | CHEMBL4030909 | assay format |
| CHEMBL4069412 |  |
Ki | = | 100.0 | nM | 377.29 | CN1C[C@H](Nc2cnn(C)c(=O)c2Br)C[C@H](c2ccccc2)C1 | Homo sapiens | CHEMBL4003560 | assay format |