Q9UL62 | TRPC5_HUMAN | Short transient receptor potential channel 5 (TRPC5)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00023 | Ank - Ankyrin repeat | 144~164 | |
| PF00520 | Ion_trans - Ion transport protein | 376~635 | |
| PF08344 | TRP_2 - Transient receptor ion channel II | 176~238 | |
| PF12796 | Ank_2 - Ankyrin repeats (3 copies) | 38~118 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4546097 |  |
IC50 | = | 0.52 | nM | 475.33 | Cn1c(=O)n(CCCO)c(=O)c2c1nc(Oc1cccc(Cl)c1)n2Cc1ccc(Cl)cc1 | Homo sapiens | CHEMBL4377071 | cell-based format |
| CHEMBL4476390 |  |
IC50 | <= | 1.0 | nM | 514.5 | Cn1c(=O)n(CCCCO)c(=O)c2c(Cc3ccccc3)c(Oc3cccc(OC(F)(F)F)c3)ccc21 | Homo sapiens | CHEMBL4377078 | cell-based format |
| CHEMBL4581773 |  |
IC50 | <= | 1.0 | nM | 400.45 | CCCOc1ccc2c(c1Cc1ccc(F)cc1)c(=O)n(CCCO)c(=O)n2C | Homo sapiens | CHEMBL4377078 | cell-based format |
| CHEMBL4462719 |  |
IC50 | <= | 1.0 | nM | 450.92 | Cn1c(=O)n(CCCO)c(=O)c2c(Cc3ccccc3)c(Oc3cccc(Cl)c3)ccc21 | Homo sapiens | CHEMBL4377078 | cell-based format |
| CHEMBL4459054 |  |
IC50 | < | 1.0 | nM | 414.48 | CCCCOc1ccc2c(c1Cc1ccc(F)cc1)c(=O)n(CCCO)c(=O)n2C | Homo sapiens | CHEMBL4426333 | cell-based format |
| CHEMBL4554717 |  |
IC50 | <= | 1.0 | nM | 518.46 | Cn1c(=O)n(CCCO)c(=O)c2c(Cc3ccc(F)cc3)c(Oc3cccc(OC(F)(F)F)c3)ccc21 | Homo sapiens | CHEMBL4377078 | cell-based format |
| CHEMBL4466522 |  |
IC50 | = | 1.3 | nM | 524.88 | Cn1c(=O)n(CCCO)c(=O)c2c1nc(Oc1cccc(OC(F)(F)F)c1)n2Cc1ccc(Cl)cc1 | Homo sapiens | CHEMBL4377063 | cell-based format |
| CHEMBL3920228 |  |
IC50 | = | 1.91 | nM | 524.95 | Cn1c(=O)n(CCCO)c(=O)c2c(Cc3ccc(Cl)cc3)c(-c3cccc(OC(F)(F)F)c3)sc21 | Homo sapiens | CHEMBL3889027 | cell-based format |
| CHEMBL4466158 |  |
IC50 | = | 2.64 | nM | 400.45 | CC(C)Oc1ccc2c(c1Cc1ccc(F)cc1)c(=O)n(CCCO)c(=O)n2C | Homo sapiens | CHEMBL4426333 | cell-based format |
| CHEMBL4525688 |  |
IC50 | = | 2.69 | nM | 500.47 | Cn1c(=O)n(CCCO)c(=O)c2c(Cc3ccccc3)c(Oc3cccc(OC(F)(F)F)c3)ccc21 | Homo sapiens | CHEMBL4426333 | cell-based format |
| CHEMBL4562137 |  |
IC50 | = | 8.37 | nM | 372.4 | COc1ccc2c(c1Cc1ccc(F)cc1)c(=O)n(CCCO)c(=O)n2C | Homo sapiens | CHEMBL4426334 | cell-based format |
| CHEMBL3975501 |  |
IC50 | < | 21.0 | nM | 414.41 | Cc1c(-c2ccccc2OC(F)(F)F)sc2c1c(=O)n(CCCO)c(=O)n2C | Homo sapiens | CHEMBL3889027 | cell-based format |
| CHEMBL3949592 |  |
IC50 | <= | 21.0 | nM | 365.84 | Cc1c(-c2cncc(Cl)c2)sc2c1c(=O)n(CCCO)c(=O)n2C | Homo sapiens | CHEMBL4377078 | cell-based format |
| CHEMBL3932679 |  |
IC50 | <= | 21.0 | nM | 503.38 | O=c1c2c(Cc3ccc(Cl)cc3)c(-c3cccc(Cl)c3)oc2n(CCCO)c(=O)n1CCCO | Homo sapiens | CHEMBL4377078 | cell-based format |
| CHEMBL4464289 |  |
IC50 | = | 27.0 | nM | 354.41 | COc1ccc2c(c1Cc1ccccc1)c(=O)n(CCCO)c(=O)n2C | Homo sapiens | CHEMBL4426333 | cell-based format |
| CHEMBL3942703 |  |
IC50 | = | 27.0 | nM | 475.4 | Cn1c(=O)n(CCCO)c(=O)c2c(Cc3ccc(Cl)cc3)c(-c3cccc(Cl)c3)sc21 | Homo sapiens | CHEMBL3889027 | cell-based format |
| CHEMBL3928277 |  |
IC50 | = | 27.0 | nM | 364.85 | Cc1c(-c2ccccc2Cl)sc2c1c(=O)n(CCCO)c(=O)n2C | Homo sapiens | CHEMBL3889027 | cell-based format |
| CHEMBL3935541 |  |
IC50 | < | 27.0 | nM | 399.3 | Cc1c(-c2ccc(Cl)c(Cl)c2)sc2c1c(=O)n(CCCO)c(=O)n2C | Homo sapiens | CHEMBL3889027 | cell-based format |
| CHEMBL3942647 |  |
IC50 | = | 27.0 | nM | 348.4 | Cc1c(-c2cccc(F)c2)sc2c1c(=O)n(CCCO)c(=O)n2C | Homo sapiens | CHEMBL3889027 | cell-based format |
| CHEMBL3937276 |  |
IC50 | < | 27.0 | nM | 416.4 | Cc1c(-c2ccc(F)c(C(F)(F)F)c2)sc2c1c(=O)n(CCCO)c(=O)n2C | Homo sapiens | CHEMBL3889027 | cell-based format |