Q9UKV0 | HDAC9_HUMAN | Histone deacetylase 9 (HDAC9)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00850 | Hist_deacetyl - Histone deacetylase domain | 654~972 | |
| PF12203 | HDAC4_Gln - Glutamine rich N terminal domain of histone deacetylase 4 | 37~124 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL27759 |  |
IC50 | = | 0.5 | nM | 376.42 | Nc1ccccc1NC(=O)c1ccc(CNC(=O)OCc2cccnc2)cc1 | Homo sapiens | CHEMBL4771418 | single protein format |
| CHEMBL3692689 |  |
IC50 | = | 0.9 | nM | 418.42 | C[C@H](CN(C)Cc1ccccc1)NC(=O)c1ccc(-c2noc(C(F)(F)F)n2)cc1 | Homo sapiens | CHEMBL5156170 | single protein format |
| CHEMBL2414098 |  |
IC50 | = | 1.1 | nM | 340.22 | O=C(CCCCCCc1nc2ccc(Br)cc2[nH]1)NO | Homo sapiens | CHEMBL2417249 | single protein format |
| CHEMBL485514 |  |
IC50 | = | 2.3 | nM | 350.42 | O=C(C=C1c2ccccc2-c2ccccc21)NCCCCCC(=O)NO | Homo sapiens | CHEMBL960372 | single protein format |
| CHEMBL484073 |  |
IC50 | = | 2.8 | nM | 327.38 | O=C(/C=C/c1ccc2cccnc2c1)NCCCCCC(=O)NO | Homo sapiens | CHEMBL960372 | single protein format |
| CHEMBL484489 |  |
IC50 | = | 3.9 | nM | 328.77 | O=C(/C=C/c1ccc(Cl)cc1F)NCCCCCC(=O)NO | Homo sapiens | CHEMBL960372 | single protein format |
| CHEMBL490018 |  |
IC50 | = | 4.2 | nM | 316.4 | CC(/C=C/c1ccccc1)=C\C(=O)NCCCCCC(=O)NO | Homo sapiens | CHEMBL960372 | single protein format |
| CHEMBL3309297 |  |
IC50 | = | 5.2 | nM | 399.49 | CC1(C)CC(=O)Nc2ccc(C(=O)NC[C@H]3CC[C@H](/C=C/C(=O)NO)CC3)cc21 | Homo sapiens | CHEMBL3373902 | single protein format |
| CHEMBL2105763 |  |
IC50 | = | 6.7 | nM | 394.48 | Cn1cc(CNCC2CCN(c3ncc(C(=O)NO)cn3)CC2)c2ccccc21 | Homo sapiens | CHEMBL4376742 | cell-based format |
| CHEMBL356066 |  |
IC50 | = | 8.24 | nM | 379.46 | O=C(/C=C/c1ccc(CN(CCO)CCc2c[nH]c3ccccc23)cc1)NO | Homo sapiens | CHEMBL1634307 | single protein format |
| CHEMBL3692671 |  |
IC50 | = | 10.0 | nM | 398.43 | CCCN(CCC)C[C@@H](C)NC(=O)c1ccc(-c2noc(C(F)(F)F)n2)cc1 | Homo sapiens | CHEMBL4689590 | single protein format |
| CHEMBL4751615 |  |
IC50 | = | 16.0 | nM | 456.42 | CC(C)(CNC(=O)c1cccc(-c2noc(C(F)(F)F)n2)c1)c1coc(-c2ccccc2)n1 | Homo sapiens | CHEMBL4737694 | single protein format |
| CHEMBL518821 |  |
IC50 | = | 20.0 | nM | 422.34 | O=C(c1ccc(-c2nc(COc3ccc(-c4nnco4)cc3)no2)s1)C(F)(F)F | Homo sapiens | CHEMBL3112171 | single protein format |
| CHEMBL4748500 |  |
IC50 | = | 20.0 | nM | 372.38 | O=C(NO)c1ccc(CN2C(=O)c3ccccc3C2=O)cc1-c1ccccc1 | Homo sapiens | CHEMBL4737694 | single protein format |
| CHEMBL3110004 |  |
IC50 | = | 20.0 | nM | 514.53 | O=C(NCC1(c2nc(-c3ccccc3)cs2)CCOCC1)c1cccc(-c2noc(C(F)(F)F)n2)c1 | Homo sapiens | CHEMBL3112171 | single protein format |
| CHEMBL3311465 |  |
IC50 | = | 25.0 | nM | 333.39 | O=C(CCCCCCC(=O)Nc1ccc2c(c1)CCC(=O)N2)NO | Homo sapiens | CHEMBL3373902 | single protein format |
| CHEMBL609583 |  |
IC50 | = | 28.0 | nM | 413.46 | O=C(NO)c1cnc(N2CCN(S(=O)(=O)c3ccc4ccccc4c3)CC2)nc1 | Homo sapiens | CHEMBL1068534 | single protein format |
| CHEMBL4798111 |  |
IC50 | = | 30.0 | nM | 382.39 | C[C@H](CN1CCC[C@@H]1C)NC(=O)c1ccc(-c2noc(C(F)(F)F)n2)cc1 | Homo sapiens | CHEMBL4689590 | single protein format |
| CHEMBL3110001 |  |
IC50 | = | 30.0 | nM | 305.34 | O=C(NO)[C@@H]1[C@H](c2ccccc2)[C@H]1c1ccc2nccnc2c1 | Homo sapiens | CHEMBL3112171 | single protein format |
| CHEMBL4437833 |  |
IC50 | = | 30.0 | nM | 337.35 | Cc1ncc(-c2ccc(C(C(=O)NO)c3ccccc3F)cc2)cn1 | Homo sapiens | CHEMBL4310911 | cell-based format |