Q9UKP6 | UR2R_HUMAN | Urotensin-2 receptor (UTS2R)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 68~315 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1164032 |  |
IC50 | = | 3.6 | nM | 516.62 | Cc1cc(NC(=O)NCCN2CCC(O)(Cc3ccccc3)CC2)c2ccccc2n1.O=S(=O)(O)O | Homo sapiens | CHEMBL1167042 | single protein format |
| CHEMBL567303 |  |
IC50 | < | 5.0 | nM | 418.54 | Cc1cc(NC(=O)NCCN2CCC(O)(Cc3ccccc3)CC2)c2ccccc2n1 | Homo sapiens | CHEMBL2351683 | cell-based format |
| CHEMBL522770 |  |
IC50 | = | 6.0 | nM | 539.37 | COc1cc(Br)c(S(=O)(=O)Nc2ccc(C(F)(F)F)c(O[C@@H]3CCN(C)C3)c2)cc1OC | Homo sapiens | CHEMBL2351692 | cell-based format |
| CHEMBL4457118 |  |
IC50 | = | 6.0 | nM | 515.99 | O=C(c1ccc(-c2ccc(F)c(F)c2)o1)N1CCN(Cc2ccc(OC3CCNCC3)c(Cl)c2)CC1 | Homo sapiens | CHEMBL4332940 | cell-based format |
| CHEMBL4525919 |  |
IC50 | = | 9.0 | nM | 498.0 | O=C(c1ccc(-c2cccc(F)c2)o1)N1CCN(Cc2ccc(OC3CCNCC3)c(Cl)c2)CC1 | Homo sapiens | CHEMBL4332940 | cell-based format |
| CHEMBL3358687 |  |
IC50 | = | 13.0 | nM | 428.53 | O=C(NCCN1CCC(O)(Cc2ccc(F)cc2)CC1)Nc1ccnc2ccsc12 | Homo sapiens | CHEMBL3382934 | cell-based format |
| CHEMBL4463082 |  |
IC50 | = | 14.0 | nM | 508.06 | CCc1ccccc1-c1ccc(C(=O)N2CCN(Cc3ccc(OC4CCNCC4)c(Cl)c3)CC2)o1 | Homo sapiens | CHEMBL4332940 | cell-based format |
| CHEMBL4581735 |  |
IC50 | = | 15.0 | nM | 538.09 | CC(C)Oc1ccccc1-c1ccc(C(=O)N2CCN(Cc3ccc(OC4CCNCC4)c(Cl)c3)CC2)o1 | Homo sapiens | CHEMBL4332940 | cell-based format |
| CHEMBL4588098 |  |
IC50 | = | 15.0 | nM | 515.99 | O=C(c1ccc(-c2cccc(F)c2F)o1)N1CCN(Cc2ccc(OC3CCNCC3)c(Cl)c2)CC1 | Homo sapiens | CHEMBL4332940 | cell-based format |
| CHEMBL4437224 |  |
IC50 | = | 15.0 | nM | 510.03 | COc1cccc(-c2ccc(C(=O)N3CCN(Cc4ccc(OC5CCNCC5)c(Cl)c4)CC3)o2)c1 | Homo sapiens | CHEMBL4332940 | cell-based format |
| CHEMBL4461733 |  |
IC50 | = | 15.0 | nM | 548.01 | O=C(c1ccc(-c2ccccc2C(F)(F)F)o1)N1CCN(Cc2ccc(OC3CCNCC3)c(Cl)c2)CC1 | Homo sapiens | CHEMBL4332940 | cell-based format |
| CHEMBL4546510 |  |
IC50 | = | 18.0 | nM | 494.04 | Cc1ccccc1-c1ccc(C(=O)N2CCN(Cc3ccc(OC4CCNCC4)c(Cl)c3)CC2)o1 | Homo sapiens | CHEMBL4332940 | cell-based format |
| CHEMBL4580364 |  |
IC50 | = | 18.0 | nM | 524.06 | CCOc1ccccc1-c1ccc(C(=O)N2CCN(Cc3ccc(OC4CCNCC4)c(Cl)c3)CC2)o1 | Homo sapiens | CHEMBL4332940 | cell-based format |
| CHEMBL4543925 |  |
IC50 | = | 20.0 | nM | 514.45 | O=C(c1ccc(-c2cccc(Cl)c2)o1)N1CCN(Cc2ccc(OC3CCNCC3)c(Cl)c2)CC1 | Homo sapiens | CHEMBL4332940 | cell-based format |
| CHEMBL3358682 |  |
IC50 | = | 20.0 | nM | 424.57 | Cc1ccccc1CC1(O)CCN(CCNC(=O)Nc2ccnc3ccsc23)CC1 | Homo sapiens | CHEMBL3382934 | cell-based format |
| CHEMBL3358685 |  |
IC50 | = | 20.0 | nM | 489.44 | O=C(NCCN1CCC(O)(Cc2ccccc2Br)CC1)Nc1ccnc2ccsc12 | Homo sapiens | CHEMBL3382934 | cell-based format |
| CHEMBL2348501 |  |
IC50 | = | 23.0 | nM | 505.82 | COc1cc(Br)c(S(=O)(=O)Nc2ccc(Cl)c(O[C@@H]3CCN(C)C3)c2)cc1OC | Homo sapiens | CHEMBL2351692 | cell-based format |
| CHEMBL4449461 |  |
IC50 | = | 24.0 | nM | 556.11 | O=C(c1ccc(-c2cccc(-c3ccccc3)c2)o1)N1CCN(Cc2ccc(OC3CCNCC3)c(Cl)c2)CC1 | Homo sapiens | CHEMBL4332940 | cell-based format |
| CHEMBL4529337 |  |
IC50 | = | 24.0 | nM | 515.99 | O=C(c1ccc(-c2cc(F)ccc2F)o1)N1CCN(Cc2ccc(OC3CCNCC3)c(Cl)c2)CC1 | Homo sapiens | CHEMBL4332940 | cell-based format |
| CHEMBL3977330 |  |
IC50 | = | 25.0 | nM | 553.53 | N#Cc1ccc2sc(C(=O)NC3CCN(Cc4ccc(OC5CCNCC5)c(Br)c4)CC3)cc2c1 | Homo sapiens | CHEMBL3859200 | cell-based format |