Q9UKK3 | PARP4_HUMAN | Protein mono-ADP-ribosyltransferase PARP4 (PARP4)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00092 | VWA - von Willebrand factor type A domain | 877~1029 | |
| PF00533 | BRCT - BRCA1 C Terminus (BRCT) domain | 3~81 | |
| PF00644 | PARP - Poly(ADP-ribose) polymerase catalytic domain | 389~565 | |
| PF08487 | VIT - Vault protein inter-alpha-trypsin domain | 623~733 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5402698 |  |
IC50 | = | 1.0 | nM | 549.36 | O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCn2c(nnc2-c2ccc(Br)o2)C1 | Homo sapiens | CHEMBL5366430 | single protein format |
| CHEMBL3764816 |  |
IC50 | = | 254.0 | nM | 380.36 | Cn1ncnc1[C@@H]1c2n[nH]c(=O)c3cc(F)cc(c23)N[C@H]1c1ccc(F)cc1 | Homo sapiens | CHEMBL3995363 | assay format |
| CHEMBL1094636 |  |
IC50 | = | 330.0 | nM | 320.4 | NC(=O)c1cccc2cn(-c3ccc([C@@H]4CCCNC4)cc3)nc12 | Homo sapiens | CHEMBL1116321 | single protein format |
| CHEMBL521686 |  |
IC50 | = | 410.0 | nM | 434.47 | O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCN(C(=O)C2CC2)CC1 | Homo sapiens | CHEMBL3995363 | assay format |
| CHEMBL595018 |  |
IC50 | = | 440.0 | nM | 307.35 | O=C1NCC2c3c(cccc31)CCN2C(=O)Cc1cccnc1 | Homo sapiens | CHEMBL1074656 | single protein format |
| CHEMBL5198711 |  |
IC50 | = | 500.0 | nM | 298.37 | Cc1cc(C)c2nc(CSc3ncccn3)[nH]c(=O)c2c1 | Homo sapiens | CHEMBL5108304 | assay format |
| CHEMBL609002 |  |
IC50 | = | 660.0 | nM | 322.37 | O=C1NCC2c3c(cccc31)CCN2C(=O)CCc1cnccn1 | Homo sapiens | CHEMBL1074656 | single protein format |
| CHEMBL5181770 |  |
IC50 | = | 800.0 | nM | 363.24 | Cc1cc(Br)cc2c(=O)[nH]c(CSc3ncccn3)nc12 | Homo sapiens | CHEMBL5108304 | assay format |
| CHEMBL5200299 |  |
IC50 | = | 800.0 | nM | 452.27 | Cc1cc(I)cc2c(=O)[nH]c(CSc3ccc(C(=O)O)cc3)nc12 | Homo sapiens | CHEMBL5108304 | assay format |
| CHEMBL1173055 |  |
IC50 | = | 839.0 | nM | 323.37 | CNCc1ccc(-c2[nH]c3cc(F)cc4c3c2CCNC4=O)cc1 | Homo sapiens | CHEMBL3995363 | assay format |