Q9UK80 | UBP21_HUMAN | Ubiquitin carboxyl-terminal hydrolase 21 (USP21)

Helixβ‑strandTurn secondary structure

Pfam Domain Table

AccessionDomainRangeColor
PF00443UCH212–555

 3D structures mapped by conservation among orthologs

[ Domain: "Cysteine proteinases" // UCH ]

 PyMOL session


 [ Alpha Fold Model ] (go)



 Known binders annotated in ChEMBL

 IC50 CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL5279102 IC50 = 6.0 nM 507.58 CC(C)C[C@@H](NC(=O)C1(C(F)(F)F)CCCCC1)C(=O)Nc1nnc(Cc2ccc(C#N)cc2)s1 Homo sapiens CHEMBL5251097 single protein format
CHEMBL5268828 IC50 = 12.0 nM 519.59 N#Cc1ccc(Cc2nnc(NC(=O)[C@H](NC(=O)C3(C(F)(F)F)CCCCC3)C3CCCC3)s2)cc1 Homo sapiens CHEMBL5251097 single protein format
CHEMBL5286335 IC50 = 18.0 nM 481.5 N#Cc1ccc(Cc2nnc(NC(=O)[C@@H](CO)NC(=O)C3(C(F)(F)F)CCCCC3)s2)cc1 Homo sapiens CHEMBL5251097 single protein format
CHEMBL5277351 IC50 = 32.0 nM 455.58 CCC1(C(=O)N[C@H](COC)C(=O)Nc2nnc(Cc3ccc(C#N)cc3)s2)CCCCC1 Homo sapiens CHEMBL5251097 single protein format
CHEMBL5271965 IC50 = 45.0 nM 495.53 COC[C@@H](NC(=O)C1(C(F)(F)F)CCCCC1)C(=O)Nc1nnc(Cc2ccc(C#N)cc2)s1 Homo sapiens CHEMBL5251097 single protein format
CHEMBL5279700 IC50 = 65.0 nM 454.6 COC[C@@H](NC(=O)C1(C)CCCCC1)C(=O)Nc1sc(Cc2ccc(C#N)cc2)nc1C Homo sapiens CHEMBL5251097 single protein format
CHEMBL5280287 IC50 = 72.0 nM 454.6 COC[C@@H](NC(=O)C1(C)CCCCC1)C(=O)Nc1nc(C)c(Cc2ccc(C#N)cc2)s1 Homo sapiens CHEMBL5251097 single protein format
CHEMBL5275560 IC50 = 73.0 nM 441.56 COC[C@@H](NC(=O)C1(C)CCCCC1)C(=O)Nc1nnc(Cc2ccc(C#N)cc2)s1 Homo sapiens CHEMBL5251097 single protein format
CHEMBL5275910 IC50 = 74.0 nM 461.54 COC[C@@H](NC(=O)C1(C)CCCCC1)C(=O)Nc1nnc(Cc2ccc([N+](=O)[O-])cc2)s1 Homo sapiens CHEMBL5251097 single protein format
CHEMBL5267932 IC50 = 84.0 nM 477.54 COC[C@@H](NC(=O)C1(C(F)F)CCCCC1)C(=O)Nc1nnc(Cc2ccc(C#N)cc2)s1 Homo sapiens CHEMBL5251097 single protein format
CHEMBL5266176 IC50 = 100.0 nM 509.55 CC(C)(O)[C@@H](NC(=O)C1(C(F)(F)F)CCCCC1)C(=O)Nc1nnc(Cc2ccc(C#N)cc2)s1 Homo sapiens CHEMBL5251097 single protein format
CHEMBL5274527 IC50 = 119.0 nM 461.54 COCC(NC(=O)C1(C)CCCCC1)C(=O)Nc1nnc(Cc2ccc([N+](=O)[O-])cc2)s1 Homo sapiens CHEMBL5251097 single protein format
CHEMBL5278034 IC50 = 754.0 nM 447.52 COCC(NC(=O)C1CCCCC1)C(=O)Nc1nnc(Cc2ccc([N+](=O)[O-])cc2)s1 Homo sapiens CHEMBL5251097 single protein format