Q9UJM8 | HAOX1_HUMAN | 2-Hydroxyacid oxidase 1 (HAO1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01070 | FMN_dh - FMN-dependent dehydrogenase | 15~361 |
3D structures mapped by conservation among orthologs
[ Domain: "TIM barrels" // IMPDH_1st ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4857427 |  |
IC50 | = | 6.7 | nM | 255.69 | O=C(O)c1[nH]nnc1Sc1ccc(Cl)cc1 | Homo sapiens | CHEMBL4827633 | assay format |
| CHEMBL5086346 |  |
IC50 | = | 21.0 | nM | 408.42 | CN(C)c1noc(-c2cccc(CN(C)c3ccc4[nH]nc(C(=O)O)c4c3)c2O)n1 | Homo sapiens | CHEMBL5036693 | single protein format |
| CHEMBL5078184 |  |
IC50 | = | 23.0 | nM | 380.43 | Cc1csc(-c2cccc(CNc3ccc4[nH]nc(C(=O)O)c4c3)c2O)n1 | Homo sapiens | CHEMBL5036693 | single protein format |
| CHEMBL5090889 |  |
IC50 | = | 24.0 | nM | 422.45 | CCN(Cc1cccc(-c2nc(N(C)C)no2)c1O)c1ccc2[nH]nc(C(=O)O)c2c1 | Homo sapiens | CHEMBL5036693 | single protein format |
| CHEMBL5083082 |  |
IC50 | = | 25.0 | nM | 394.46 | Cc1nc(-c2cccc(CNc3ccc4[nH]nc(C(=O)O)c4c3)c2O)sc1C | Homo sapiens | CHEMBL5036693 | single protein format |
| CHEMBL5079217 |  |
IC50 | = | 35.0 | nM | 422.51 | CC(C)c1csc(-c2cccc(CN(C)c3ccc4[nH]nc(C(=O)O)c4c3)c2O)n1 | Homo sapiens | CHEMBL5036693 | single protein format |
| CHEMBL5080894 |  |
IC50 | = | 35.0 | nM | 436.47 | CC(C)N(Cc1cccc(-c2nc(N(C)C)no2)c1O)c1ccc2[nH]nc(C(=O)O)c2c1 | Homo sapiens | CHEMBL5036693 | single protein format |
| CHEMBL5081182 |  |
IC50 | = | 37.0 | nM | 394.39 | CN(C)c1noc(-c2cccc(CNc3ccc4[nH]nc(C(=O)O)c4c3)c2O)n1 | Homo sapiens | CHEMBL5036693 | single protein format |
| CHEMBL5077149 |  |
IC50 | = | 47.0 | nM | 393.4 | CC(C)c1noc(-c2cccc(CNc3ccc4[nH]nc(C(=O)O)c4c3)c2O)n1 | Homo sapiens | CHEMBL5036693 | single protein format |
| CHEMBL5084900 |  |
IC50 | = | 65.0 | nM | 408.48 | CC(C)c1csc(-c2cccc(CNc3ccc4[nH]nc(C(=O)O)c4c3)c2O)n1 | Homo sapiens | CHEMBL5036693 | single protein format |
| CHEMBL5079471 |  |
IC50 | = | 87.0 | nM | 392.42 | CC(C)c1coc(-c2cccc(CNc3ccc4[nH]nc(C(=O)O)c4c3)c2O)n1 | Homo sapiens | CHEMBL5036693 | single protein format |
| CHEMBL5090196 |  |
IC50 | = | 110.0 | nM | 471.32 | CN(Cc1ccc(F)cc1-c1ccc(C(=O)O)c(Cl)c1)C(=O)c1cc2ccc(Cl)cc2[nH]1 | Homo sapiens | CHEMBL5036693 | single protein format |
| CHEMBL5075215 |  |
IC50 | = | 170.0 | nM | 378.39 | CN(C)c1noc(-c2cccc(CNc3ccc4[nH]nc(C(=O)O)c4c3)c2)n1 | Homo sapiens | CHEMBL5036693 | single protein format |
| CHEMBL5080981 |  |
IC50 | = | 180.0 | nM | 412.84 | CN(C)c1noc(-c2cccc(CNc3ccc4[nH]nc(C(=O)O)c4c3)c2Cl)n1 | Homo sapiens | CHEMBL5036693 | single protein format |
| CHEMBL5078643 |  |
IC50 | = | 190.0 | nM | 344.16 | O=C1NC(=O)C(c2ccc(-c3ccc(Br)cc3)cc2)C1=O | Homo sapiens | CHEMBL5036693 | single protein format |
| CHEMBL5072756 |  |
IC50 | = | 290.0 | nM | 392.48 | Cc1nc(-c2cccc(CN(C)c3ccc4[nH]nc(C(=O)O)c4c3)c2)sc1C | Homo sapiens | CHEMBL5036693 | single protein format |
| CHEMBL5075958 |  |
IC50 | = | 510.0 | nM | 340.38 | CCCOc1ncccc1CN(C)c1ccc2[nH]nc(C(=O)O)c2c1 | Homo sapiens | CHEMBL5036693 | single protein format |
| CHEMBL5084629 |  |
IC50 | = | 650.0 | nM | 378.46 | Cc1csc(-c2cccc(CN(C)c3ccc4[nH]nc(C(=O)O)c4c3)c2)n1 | Homo sapiens | CHEMBL5036693 | single protein format |
| CHEMBL5078345 |  |
IC50 | = | 710.0 | nM | 406.51 | CC(C)c1csc(-c2cccc(CN(C)c3ccc4[nH]nc(C(=O)O)c4c3)c2)n1 | Homo sapiens | CHEMBL5036693 | single protein format |
| CHEMBL5085053 |  |
IC50 | = | 860.0 | nM | 391.43 | CC(C)n1ccc(-c2cccc(CNc3ccc4[nH]nc(C(=O)O)c4c3)c2O)n1 | Homo sapiens | CHEMBL5036693 | single protein format |