Q9UIQ6 | LCAP_HUMAN | Leucyl-cystinyl aminopeptidase (LNPEP)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01433 | Peptidase_M1 - Peptidase family M1 domain | 392~610 | |
| PF11838 | ERAP1_C - ERAP1-like C-terminal domain | 689~1008 | |
| PF17900 | Peptidase_M1_N - Peptidase M1 N-terminal domain | 173~358 |
3D structures mapped by conservation among orthologs
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // ERAP1_C ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // KOG1046 ]
[ Domain: "Baculovirus p35 protein-related" // Peptidase_M1_2 ]
[ Domain: "ARM repeat" // ERAP1_C_1 ]
[ Domain: "Metalloproteases ("zincins") catalytic domain" // Peptidase_M1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4101200 |  |
IC50 | = | 2.0 | nM | 455.5 | C#CC[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | Homo sapiens | CHEMBL4024807 | cell-based format |
| CHEMBL4095882 |  |
IC50 | = | 4.0 | nM | 590.62 | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cc(-c2ccc(O)cc2)no1)CP(=O)(O)[C@@H](N)CCc1ccccc1 | Homo sapiens | CHEMBL4024807 | cell-based format |
| CHEMBL4077855 |  |
IC50 | = | 9.0 | nM | 590.62 | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cc(-c2ccccc2O)no1)CP(=O)(O)[C@@H](N)CCc1ccccc1 | Homo sapiens | CHEMBL4024807 | cell-based format |
| CHEMBL4089555 |  |
IC50 | = | 14.0 | nM | 423.49 | CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N1CCC[C@H]1C(N)=O | Homo sapiens | CHEMBL4024807 | cell-based format |
| CHEMBL4069576 |  |
IC50 | = | 16.0 | nM | 563.68 | CC(C)C[C@H](NC(=O)[C@H](CC(c1ccccc1)c1ccccc1)CP(=O)(O)[C@@H](N)CCc1ccccc1)C(N)=O | Homo sapiens | CHEMBL4024807 | cell-based format |
| CHEMBL4069425 |  |
IC50 | = | 18.0 | nM | 574.62 | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cc(-c2ccccc2)no1)CP(=O)(O)[C@@H](N)CCc1ccccc1 | Homo sapiens | CHEMBL4024807 | cell-based format |
| CHEMBL4097268 |  |
IC50 | = | 29.0 | nM | 489.55 | CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O | Homo sapiens | CHEMBL4024807 | cell-based format |
| CHEMBL3416733 |  |
IC50 | = | 30.0 | nM | 512.59 | CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | Homo sapiens | CHEMBL3419982 | cell-based format |
| CHEMBL4065841 |  |
IC50 | = | 32.0 | nM | 597.7 | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(c1ccccc1)c1ccccc1)CP(=O)(O)[C@@H](N)CCc1ccccc1 | Homo sapiens | CHEMBL4024807 | cell-based format |
| CHEMBL4081682 |  |
IC50 | = | 32.0 | nM | 439.54 | CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O | Homo sapiens | CHEMBL4024807 | cell-based format |
| CHEMBL4099693 |  |
IC50 | = | 41.0 | nM | 473.55 | CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | Homo sapiens | CHEMBL4024807 | cell-based format |
| CHEMBL4074464 |  |
IC50 | = | 46.0 | nM | 565.69 | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC12CC3CC(CC(C3)C1)C2)CP(=O)(O)[C@@H](N)CCc1ccccc1 | Homo sapiens | CHEMBL4024807 | cell-based format |
| CHEMBL4091951 |  |
IC50 | = | 102.0 | nM | 397.46 | CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](C)C(N)=O | Homo sapiens | CHEMBL4024807 | cell-based format |
| CHEMBL3416692 |  |
IC50 | = | 105.0 | nM | 541.65 | CCCC[C@H](N)C(=O)Nc1cc(C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)OCc2ccccc2)ccc1N | Homo sapiens | CHEMBL3419982 | cell-based format |
| CHEMBL4077711 |  |
IC50 | = | 185.0 | nM | 473.55 | CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | Homo sapiens | CHEMBL4024807 | cell-based format |
| CHEMBL4096799 |  |
IC50 | = | 221.0 | nM | 597.7 | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(c1ccccc1)c1ccccc1)CP(=O)(O)[C@@H](N)CCc1ccccc1 | Homo sapiens | CHEMBL4024807 | cell-based format |
| CHEMBL3416693 |  |
IC50 | = | 296.0 | nM | 451.53 | CCCC[C@H](N)C(=O)Nc1cc(C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)ccc1N | Homo sapiens | CHEMBL3419982 | cell-based format |
| CHEMBL4066723 |  |
IC50 | = | 381.0 | nM | 463.52 | CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O | Homo sapiens | CHEMBL4024807 | cell-based format |
| CHEMBL4096656 |  |
IC50 | = | 434.0 | nM | 574.62 | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cc(-c2ccccc2)no1)CP(=O)(O)[C@@H](N)CCc1ccccc1 | Homo sapiens | CHEMBL4024807 | cell-based format |
| CHEMBL3416726 |  |
IC50 | = | 438.0 | nM | 541.65 | CCCC[C@H](N)C(=O)Nc1ccc(C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)OCc2ccccc2)cc1N | Homo sapiens | CHEMBL3419982 | cell-based format |