Q9UHP3 | UBP25_HUMAN | Ubiquitin carboxyl-terminal hydrolase 25 (USP25)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00443 | UCH - Ubiquitin carboxyl-terminal hydrolase | 169~654 | |
| PF21909 | USP_UIM_N - Ubiquitin-specific protease UIM domain | 70~132 | |
| PF22566 | UBA_8 - UBA-like domain | 16~60 |
3D structures mapped by conservation among orthologs
[ Domain: "RuvA-C, UBA, CRAL/TRIO-N, HBS1" // UBA_4 ]
[ Domain: "C-terminal domain of USP25" // UNK_F_TYPE ]
[ Domain: "Cysteine proteinases" // UCH ]
[ Domain: "UIM domain" // UIM_like ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4514675 |  |
IC50 | = | 200.0 | nM | 424.57 | CCNc1ccc2c(N)c(C(=O)NCCc3ccc(N4CCNCC4)cc3)sc2n1 | Homo sapiens | CHEMBL4477146 | single protein format |
| CHEMBL4541872 |  |
IC50 | = | 200.0 | nM | 438.57 | Cc1ccc2c(N)c(C(=O)NCCc3ccc([C@H]4C[C@H]5CC[C@@H](C4)N5)cc3F)sc2n1 | Homo sapiens | CHEMBL4477146 | single protein format |
| CHEMBL4553460 |  |
IC50 | = | 200.0 | nM | 355.42 | Cc1ccc2c(N)c(C(=O)NCCc3ccc(C(=O)O)cc3)sc2n1 | Homo sapiens | CHEMBL4477146 | single protein format |
| CHEMBL4539688 |  |
IC50 | = | 200.0 | nM | 395.48 | Cc1ccc2c(N)c(C(=O)NCCc3ccc4c(c3)C[C@H](C(=O)O)C4)sc2n1 | Homo sapiens | CHEMBL4477146 | single protein format |
| CHEMBL4521357 |  |
IC50 | = | 200.0 | nM | 395.48 | Cc1ccc2c(N)c(C(=O)NCCc3ccc4c(c3)C[C@@H](C(=O)O)C4)sc2n1 | Homo sapiens | CHEMBL4477146 | single protein format |
| CHEMBL4520108 |  |
IC50 | = | 200.0 | nM | 380.52 | Cc1ccc2c(N)c(C(=O)NCCc3ccc([C@H]4CCNC4)cc3)sc2n1 | Homo sapiens | CHEMBL4477146 | single protein format |
| CHEMBL4555997 |  |
IC50 | = | 200.0 | nM | 380.52 | Cc1ccc2c(N)c(C(=O)NCCc3ccc([C@@H]4CCNC4)cc3)sc2n1 | Homo sapiens | CHEMBL4477146 | single protein format |
| CHEMBL4513397 |  |
IC50 | = | 200.0 | nM | 410.55 | Cc1cc(N)nc2sc(C(=O)NCCc3ccc(N4CCNCC4)cc3)c(N)c12 | Homo sapiens | CHEMBL4477146 | single protein format |
| CHEMBL4546241 |  |
IC50 | = | 200.0 | nM | 396.52 | Nc1ccc2c(N)c(C(=O)NCCc3ccc(N4CCNCC4)cc3)sc2n1 | Homo sapiens | CHEMBL4477146 | single protein format |
| CHEMBL4519211 |  |
IC50 | = | 200.0 | nM | 412.53 | Cc1ccc2c(N)c(C(=O)NCCc3ccc(C4CCNCC4)cc3F)sc2n1 | Homo sapiens | CHEMBL4477146 | single protein format |
| CHEMBL4535426 |  |
IC50 | = | 200.0 | nM | 411.53 | COc1ccc2c(N)c(C(=O)NCCc3ccc(N4CCNCC4)cc3)sc2n1 | Homo sapiens | CHEMBL4477146 | single protein format |
| CHEMBL4514361 |  |
IC50 | = | 200.0 | nM | 447.51 | Nc1c(C(=O)NCCc2ccc(N3CCNCC3)cc2)sc2nc(OC(F)F)ccc12 | Homo sapiens | CHEMBL4477146 | single protein format |
| CHEMBL4546374 |  |
IC50 | = | 200.0 | nM | 423.59 | CNc1ccc2c(N)c(C(=O)NCCc3ccc(C4CCN(C)CC4)cc3)sc2n1 | Homo sapiens | CHEMBL4477146 | single protein format |
| CHEMBL4516491 |  |
IC50 | = | 200.0 | nM | 424.57 | CNc1ccc2c(N)c(C(=O)NCCc3ccc(N4CCN(C)CC4)cc3)sc2n1 | Homo sapiens | CHEMBL4477146 | single protein format |
| CHEMBL4535512 |  |
IC50 | = | 200.0 | nM | 409.56 | CNc1ccc2c(N)c(C(=O)NCCc3ccc(C4CCNCC4)cc3)sc2n1 | Homo sapiens | CHEMBL4477146 | single protein format |
| CHEMBL4584300 |  |
IC50 | = | 200.0 | nM | 431.51 | CNC1CN(c2cc(F)c(CCNC(=O)c3sc4nc(C)ccc4c3N)cc2F)C1 | Homo sapiens | CHEMBL4477146 | single protein format |
| CHEMBL4549526 |  |
IC50 | = | 200.0 | nM | 423.59 | CCN[C@@H]1CCN(c2ccc(CCNC(=O)c3sc4nc(C)ccc4c3N)cc2)C1 | Homo sapiens | CHEMBL4477146 | single protein format |
| CHEMBL4564585 |  |
IC50 | = | 200.0 | nM | 463.65 | Cc1ccc2c(N)c(C(=O)NCCc3ccc(N4CCCC5(CCCNC5)C4)cc3)sc2n1 | Homo sapiens | CHEMBL4477146 | single protein format |
| CHEMBL4533281 |  |
IC50 | = | 200.0 | nM | 436.59 | CCc1cnc2c(N)c(C(=O)NCCc3ccc(N4CC5CCC(C4)N5)cc3)sc2n1 | Homo sapiens | CHEMBL4418452 | single protein format |
| CHEMBL4556023 |  |
IC50 | = | 200.0 | nM | 437.61 | Cc1ccc2c(N)c(C(=O)NCCc3ccc(N4CCN[C@H](C(C)C)C4)cc3)sc2n1 | Homo sapiens | CHEMBL4477146 | single protein format |