Q9UHC9 | NPCL1_HUMAN | NPC1-like intracellular cholesterol transporter 1 (NPC1L1)
Pfam Domain Table
Accession | Domain | Range | Color |
---|---|---|---|
PF12349 | Sterol-sensing - Sterol-sensing domain of SREBP cleavage-activation | 661~814 | |
PF16414 | NPC1_N - Niemann-Pick C1 N terminus | 31~282 | |
PF22314 | NPC1_MLD - NPC1, middle luminal domain | 394~619 |
3D structures mapped by conservation among orthologs
[ Domain: "Frizzled cysteine-rich domain-related" // NPC1_N ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
---|---|---|---|---|---|---|---|---|---|---|
CHEMBL578401 | IC50 | = | 150.0 | nM | 571.58 | [3H]c1cc([C@@H]2[C@@H](CC[C@H](O)c3ccc(F)cc3)C(=O)N2c2ccccc2[3H])ccc1O[C@@H]1O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]1O | Homo sapiens | CHEMBL1046285 | assay format | |
CHEMBL321017 | IC50 | = | 300.0 | nM | 585.56 | O=C(O)[C@H]1O[C@@H](Oc2ccc([C@@H]3[C@@H](CC[C@H](O)c4ccc(F)cc4)C(=O)N3c3ccc(F)cc3)cc2)[C@H](O)[C@@H](O)[C@@H]1O | Homo sapiens | CHEMBL970539 | cell-based format | |
CHEMBL1138 | IC50 | = | 370.0 | nM | 409.43 | O=C1[C@H](CC[C@H](O)c2ccc(F)cc2)[C@@H](c2ccc(O)cc2)N1c1ccc(F)cc1 | Homo sapiens | CHEMBL5127801 | single protein format | |
CHEMBL466245 | IC50 | = | 390.0 | nM | 526.68 | O=C(c1cccc2ccccc12)N1CC(C(=O)N2CCC3(C=Cc4ccccc43)CC2)CC(c2ccccc2)C1 | Homo sapiens | CHEMBL970539 | cell-based format | |
CHEMBL466849 | IC50 | = | 660.0 | nM | 462.59 | O=C([C@@H]1C[C@@H](c2ccccc2)CN1C(=O)c1ccccc1)N1CCC2(C=Cc3ccccc32)CC1 | Homo sapiens | CHEMBL970539 | cell-based format | |
CHEMBL1629892 | IC50 | = | 1000.0 | nM | 492.62 | CC(C)(C)c1ccc(C(=O)N2CCC3(CC2)C(=O)N(CC(=O)NCCO)CN3c2ccccc2)cc1 | Homo sapiens | CHEMBL1638622 | cell-based format |