Q9UHC9 | NPCL1_HUMAN | NPC1-like intracellular cholesterol transporter 1 (NPC1L1)

Pfam Domain Table

AccessionDomainRangeColor
PF12349Sterol-sensing - Sterol-sensing domain of SREBP cleavage-activation661~814
PF16414NPC1_N - Niemann-Pick C1 N terminus31~282
PF22314NPC1_MLD - NPC1, middle luminal domain394~619

3D structures mapped by conservation among orthologs

[ Domain: "Frizzled cysteine-rich domain-related" // NPC1_N ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL578401 IC50 = 150.0 nM 571.58 [3H]c1cc([C@@H]2[C@@H](CC[C@H](O)c3ccc(F)cc3)C(=O)N2c2ccccc2[3H])ccc1O[C@@H]1O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]1O Homo sapiens CHEMBL1046285 assay format
CHEMBL321017 IC50 = 300.0 nM 585.56 O=C(O)[C@H]1O[C@@H](Oc2ccc([C@@H]3[C@@H](CC[C@H](O)c4ccc(F)cc4)C(=O)N3c3ccc(F)cc3)cc2)[C@H](O)[C@@H](O)[C@@H]1O Homo sapiens CHEMBL970539 cell-based format
CHEMBL1138 IC50 = 370.0 nM 409.43 O=C1[C@H](CC[C@H](O)c2ccc(F)cc2)[C@@H](c2ccc(O)cc2)N1c1ccc(F)cc1 Homo sapiens CHEMBL5127801 single protein format
CHEMBL466245 IC50 = 390.0 nM 526.68 O=C(c1cccc2ccccc12)N1CC(C(=O)N2CCC3(C=Cc4ccccc43)CC2)CC(c2ccccc2)C1 Homo sapiens CHEMBL970539 cell-based format
CHEMBL466849 IC50 = 660.0 nM 462.59 O=C([C@@H]1C[C@@H](c2ccccc2)CN1C(=O)c1ccccc1)N1CCC2(C=Cc3ccccc32)CC1 Homo sapiens CHEMBL970539 cell-based format
CHEMBL1629892 IC50 = 1000.0 nM 492.62 CC(C)(C)c1ccc(C(=O)N2CCC3(CC2)C(=O)N(CC(=O)NCCO)CN3c2ccccc2)cc1 Homo sapiens CHEMBL1638622 cell-based format