Q9UHC3 | ASIC3_HUMAN | Acid-sensing ion channel 3 (ASIC3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00858 | ASC - Amiloride-sensitive sodium channel | 20~459 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1800440 |  |
IC50 | = | 190.0 | nM | 380.94 | CN(C)C1CCc2c(C#Cc3ccc4c(Cl)c(CN)sc4c3)cccc21 | Homo sapiens | CHEMBL1804676 | single protein format |
| CHEMBL1800430 |  |
IC50 | = | 220.0 | nM | 352.89 | NCc1sc2cc(C#Cc3ccc4c(c3)CNCC4)ccc2c1Cl | Homo sapiens | CHEMBL1804676 | single protein format |
| CHEMBL1800436 |  |
IC50 | = | 230.0 | nM | 394.97 | CN(C)C1CCCc2c(C#Cc3ccc4c(Cl)c(CN)sc4c3)cccc21 | Homo sapiens | CHEMBL1804676 | single protein format |
| CHEMBL1800432 |  |
IC50 | = | 230.0 | nM | 380.94 | CCN1CCc2ccc(C#Cc3ccc4c(Cl)c(CN)sc4c3)cc2C1 | Homo sapiens | CHEMBL1804676 | single protein format |
| CHEMBL1800428 |  |
IC50 | = | 270.0 | nM | 380.94 | CC1c2cc(C#Cc3ccc4c(Cl)c(CN)sc4c3)ccc2CCN1C | Homo sapiens | CHEMBL1804676 | single protein format |
| CHEMBL1800433 |  |
IC50 | = | 310.0 | nM | 394.97 | CC(C)N1CCc2ccc(C#Cc3ccc4c(Cl)c(CN)sc4c3)cc2C1 | Homo sapiens | CHEMBL1804676 | single protein format |
| CHEMBL1800331 |  |
IC50 | = | 460.0 | nM | 381.52 | CC(C)C1c2cc(C#Cc3ccc4cc(C(=N)N)ccc4c3)ccc2CCN1C | Homo sapiens | CHEMBL1804676 | single protein format |
| CHEMBL513153 |  |
IC50 | = | 490.0 | nM | 332.37 | NC(N)=NC(=O)c1ncc(-c2cccc(-c3ccccc3)c2)nc1N | Homo sapiens | CHEMBL970525 | assay format |
| CHEMBL466668 |  |
IC50 | = | 510.0 | nM | 355.79 | NC(N)=NC(=O)c1nc(Cl)c(Nc2ccc3ccccc3c2)nc1N | Homo sapiens | CHEMBL970525 | assay format |
| CHEMBL1800437 |  |
IC50 | = | 510.0 | nM | 424.01 | CCN(CC)N1CCCc2c(C#Cc3ccc4c(Cl)c(CN)sc4c3)cccc21 | Homo sapiens | CHEMBL1804676 | single protein format |
| CHEMBL467724 |  |
IC50 | = | 640.0 | nM | 338.4 | NC(N)=NC(=O)c1ncc(-c2cccc(-c3ccsc3)c2)nc1N | Homo sapiens | CHEMBL970525 | assay format |
| CHEMBL1800431 |  |
IC50 | = | 680.0 | nM | 366.92 | CN1CCc2ccc(C#Cc3ccc4c(Cl)c(CN)sc4c3)cc2C1 | Homo sapiens | CHEMBL1804676 | single protein format |