Q9UGN5 | PARP2_HUMAN | Poly [ADP-ribose] polymerase 2 (PARP2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00644 | PARP - Poly(ADP-ribose) polymerase catalytic domain | 376~577 | |
| PF02877 | PARP_reg - Poly(ADP-ribose) polymerase, regulatory domain | 232~362 | |
| PF05406 | WGR - WGR domain | 115~194 |
3D structures mapped by conservation among orthologs
[ Domain: "Domain of poly(ADP-ribose) polymerase" // PARP_reg ]
[ Domain: "WGR domain" // WGR ]
[ Domain: "ADP-ribosylation" // PARP ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5402698 |  |
IC50 | = | 0.001 | nM | 549.36 | O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCn2c(nnc2-c2ccc(Br)o2)C1 | Homo sapiens | CHEMBL5366428 | single protein format |
| CHEMBL5397373 |  |
IC50 | = | 0.1 | nM | 478.52 | O=C1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1CC1CCCC1 | Homo sapiens | CHEMBL5373884 | assay format |
| CHEMBL3984980 |  |
IC50 | = | 0.2 | nM | 364.49 | CC1(C)CC2=NNC(=O)c3cccc4c3c2c(n4CCN2CCCCC2)C1 | Homo sapiens | CHEMBL3887990 | single protein format |
| CHEMBL3907010 |  |
IC50 | = | 0.22 | nM | 486.43 | CC1CN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)Cc2nnc(C(F)(F)F)n21 | Homo sapiens | CHEMBL3887958 | single protein format |
| CHEMBL5423934 |  |
IC50 | = | 0.22 | nM | 492.55 | CC(C1CCCC1)N1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O | Homo sapiens | CHEMBL5373884 | assay format |
| CHEMBL5421335 |  |
IC50 | = | 0.24 | nM | 492.55 | O=C1CN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CCN1CC1CCCCC1 | Homo sapiens | CHEMBL5373884 | assay format |
| CHEMBL5423161 |  |
IC50 | = | 0.26 | nM | 506.58 | CC(C1CCCCC1)N1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O | Homo sapiens | CHEMBL5373884 | assay format |
| CHEMBL5439635 |  |
IC50 | = | 0.29 | nM | 464.5 | O=C(c1cc(Cn2c(=O)[nH]c(=O)c3ccccc32)ccc1F)N1CCN(C2CCCC2)C(=O)C1 | Homo sapiens | CHEMBL5373884 | assay format |
| CHEMBL5420649 |  |
IC50 | = | 0.3 | nM | 501.55 | C[C@@H]1CN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)Cc2nnc(-c3nccs3)n21 | Homo sapiens | CHEMBL5373882 | single protein format |
| CHEMBL3926240 |  |
IC50 | = | 0.3 | nM | 352.48 | CCN(CC)CCn1c2c3c4c(cccc41)C(=O)NN=C3CC(C)(C)C2 | Homo sapiens | CHEMBL3887990 | single protein format |
| CHEMBL3929889 |  |
IC50 | = | 0.3 | nM | 342.42 | CN(C)CCn1c2c3c4c(cc(F)cc41)C(=O)NN=C3CC(C)(C)C2 | Homo sapiens | CHEMBL4678540 | single protein format |
| CHEMBL3975917 |  |
IC50 | = | 0.3 | nM | 324.43 | CN(C)CCn1c2c3c4c(cccc41)C(=O)NN=C3CC(C)(C)C2 | Homo sapiens | CHEMBL4678540 | single protein format |
| CHEMBL3922789 |  |
IC50 | = | 0.3 | nM | 294.31 | O=C1NN=C2CN(C(=O)C3CC3)Cc3[nH]c4cccc1c4c32 | Homo sapiens | CHEMBL3887990 | single protein format |
| CHEMBL3933450 |  |
IC50 | = | 0.3 | nM | 378.36 | O=C1NN=C2CN(C(=O)OCc3ccccc3)Cc3[nH]c4cc(F)cc1c4c32 | Homo sapiens | CHEMBL3887990 | single protein format |
| CHEMBL5416806 |  |
IC50 | = | 0.33 | nM | 478.52 | O=C(c1cc(Cn2c(=O)[nH]c(=O)c3ccccc32)ccc1F)N1CCN(C2CCCCC2)C(=O)C1 | Homo sapiens | CHEMBL5373884 | assay format |
| CHEMBL5419831 |  |
IC50 | = | 0.33 | nM | 466.51 | CC(C)(C)CN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O | Homo sapiens | CHEMBL5373884 | assay format |
| CHEMBL5432851 |  |
IC50 | = | 0.38 | nM | 452.49 | CC(C)CN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O | Homo sapiens | CHEMBL5373884 | assay format |
| CHEMBL4107982 |  |
IC50 | = | 0.4 | nM | 280.33 | C[C@]12CCCN1CC1=NNC(=O)c3cccc4[nH]c2c1c34 | Homo sapiens | CHEMBL3887990 | single protein format |
| CHEMBL5432860 |  |
IC50 | = | 0.44 | nM | 452.49 | CCC(C)N1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O | Homo sapiens | CHEMBL5373884 | assay format |
| CHEMBL5394020 |  |
IC50 | = | 0.49 | nM | 452.49 | CCCCN1CCN(C(=O)c2cc(Cn3c(=O)[nH]c(=O)c4ccccc43)ccc2F)CC1=O | Homo sapiens | CHEMBL5373884 | assay format |