Q9UGL1 | KDM5B_HUMAN | Lysine-specific demethylase 5B (KDM5B)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00628 | PHD - PHD-finger | 312~356 | |
| PF00628 | PHD - PHD-finger | 1179~1221 | |
| PF00628 | PHD - PHD-finger | 1492~1535 | |
| PF01388 | ARID - ARID/BRIGHT DNA binding domain | 100~182 | |
| PF02373 | JmjC - JmjC domain, hydroxylase | 486~602 | |
| PF02375 | JmjN - jmjN domain | 33~66 | |
| PF02928 | zf-C5HC2 - C5HC2 zinc finger | 692~744 | |
| PF08429 | PLU-1 - PLU-1-like protein | 757~1088 | |
| PF21323 | KDM5_C-hel - Lysine-specific demethylase 5, C-terminal helical domain | 606~660 |
3D structures mapped by conservation among orthologs
[ Domain: "Double-stranded beta-helix" // JmjC ]
[ Domain: "C-terminal helical domain in Jumonji domain-containing histone demethylases" // KOG1246_1st ]
[ Domain: "FYVE/PHD zinc finger" // PHD_5 ]
[ Domain: "FYVE/PHD zinc finger" // PHD_1 ]
[ Domain: "LIM domain-like" // zf-C5HC2 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4229271 |  |
IC50 | = | 0.6 | nM | 320.31 | N#Cc1ccc(COc2ccnn2-c2cc(C(=O)O)ccn2)cc1 | Homo sapiens | CHEMBL4223291 | single protein format |
| CHEMBL4228292 |  |
IC50 | = | 1.0 | nM | 359.77 | COc1cc(Cl)ccc1COc1ccnn1-c1cc(C(=O)O)ccn1 | Homo sapiens | CHEMBL4223291 | single protein format |
| CHEMBL4228806 |  |
IC50 | = | 1.0 | nM | 384.41 | CN(C)CCc1cnn(-c2cc(C(=O)O)ccn2)c1OCc1ccc(F)cc1 | Homo sapiens | CHEMBL4223291 | single protein format |
| CHEMBL4225358 |  |
IC50 | = | 1.0 | nM | 295.3 | O=C(O)c1ccnc(-n2nccc2OCc2ccccc2)c1 | Homo sapiens | CHEMBL4223291 | single protein format |
| CHEMBL4542928 |  |
IC50 | = | 1.34 | nM | 419.57 | CCCCCCN(C)CCc1ccc(-c2[nH]c3c(C#N)cnn3c(=O)c2C(C)C)cc1 | Homo sapiens | CHEMBL4424784 | cell-based format |
| CHEMBL4226978 |  |
IC50 | = | 2.0 | nM | 374.19 | O=C(O)c1ccnc(-n2nccc2OCc2ccc(Br)cc2)c1 | Homo sapiens | CHEMBL4223291 | single protein format |
| CHEMBL3786952 |  |
IC50 | = | 2.0 | nM | 343.77 | Cc1cc(Cl)ccc1COc1ccnn1-c1cc(C(=O)O)ccn1 | Homo sapiens | CHEMBL4223291 | single protein format |
| CHEMBL4227237 |  |
IC50 | = | 3.0 | nM | 323.35 | CCc1ccc(COc2ccnn2-c2cc(C(=O)O)ccn2)cc1 | Homo sapiens | CHEMBL4223291 | single protein format |
| CHEMBL4228610 |  |
IC50 | = | 4.0 | nM | 325.32 | COc1ccc(COc2ccnn2-c2cc(C(=O)O)ccn2)cc1 | Homo sapiens | CHEMBL4223291 | single protein format |
| CHEMBL4225013 |  |
IC50 | = | 4.0 | nM | 313.29 | O=C(O)c1ccnc(-n2nccc2OCc2ccc(F)cc2)c1 | Homo sapiens | CHEMBL4223291 | single protein format |
| CHEMBL4228087 |  |
IC50 | = | 4.0 | nM | 309.32 | Cc1ccc(COc2ccnn2-c2cc(C(=O)O)ccn2)cc1 | Homo sapiens | CHEMBL4223291 | single protein format |
| CHEMBL4228546 |  |
IC50 | = | 4.0 | nM | 347.73 | O=C(O)c1ccnc(-n2nccc2OCc2ccc(Cl)cc2F)c1 | Homo sapiens | CHEMBL4223291 | single protein format |
| CHEMBL5285949 |  |
IC50 | = | 4.0 | nM | 486.58 | CN(C)C/C=C/C(=O)Nc1cccc(CN(C)CCc2cnn(-c3nccc4c(=O)[nH]cnc34)c2)c1 | Homo sapiens | CHEMBL5231380 | single protein format |
| CHEMBL4227526 |  |
IC50 | = | 4.0 | nM | 435.87 | O=C(O)c1ccnc(-n2nccc2OCc2ccc(Cl)cc2OCc2ccccc2)c1 | Homo sapiens | CHEMBL4223291 | single protein format |
| CHEMBL4229264 |  |
IC50 | = | 4.0 | nM | 373.8 | CCOc1cc(Cl)ccc1COc1ccnn1-c1cc(C(=O)O)ccn1 | Homo sapiens | CHEMBL4223291 | single protein format |
| CHEMBL3785583 |  |
IC50 | = | 4.7 | nM | 324.39 | CC(C)c1c(-c2cnn(C(C)(C)C)c2)[nH]c2c(C#N)cnn2c1=O | Homo sapiens | CHEMBL4427162 | single protein format |
| CHEMBL4438830 |  |
IC50 | = | 6.0 | nM | 471.61 | CN(C)CCc1cccc(C2CCN(CCc3cnn(-c4nccc5c(=O)[nH]cnc45)c3)CC2)c1 | Homo sapiens | CHEMBL4353690 | single protein format |
| CHEMBL4225515 |  |
IC50 | = | 6.0 | nM | 399.83 | O=C(O)c1ccnc(-n2nccc2OCc2ccc(Cl)cc2OCC2CC2)c1 | Homo sapiens | CHEMBL4223291 | single protein format |
| CHEMBL5277258 |  |
IC50 | = | 7.0 | nM | 387.83 | CC(C)c1c(-c2cnn(CCNC(=O)CCl)c2)[nH]c2c(C#N)cnn2c1=O | Homo sapiens | CHEMBL5231380 | single protein format |
| CHEMBL3775814 |  |
IC50 | = | 7.0 | nM | 425.5 | N#Cc1ccc(C2CCN(CCc3cnn(-c4nccc5c(=O)[nH]cnc45)c3)CC2)cc1 | Homo sapiens | CHEMBL3778807 | single protein format |