Q9UEE5 | ST17A_HUMAN | Serine/threonine-protein kinase 17A (STK17A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 65~321 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5085430 |  |
IC50 | = | 4.47 | nM | 516.44 | O=C(NCCCNc1nc(Nc2cccc(NC(=O)N3CCCC3)c2)ncc1Br)C1CCC1 | Homo sapiens | CHEMBL5046586 | cell-based format |
| CHEMBL495727 |  |
IC50 | = | 10.0 | nM | 381.44 | O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 | Homo sapiens | CHEMBL1009907 | single protein format |
| CHEMBL3799585 |  |
IC50 | = | 12.0 | nM | 362.39 | CCCC(=O)Nc1ccc2c(c1)/C(=C1/Nc3ccccc3/C1=N\O)C(=O)N2 | Homo sapiens | CHEMBL3802095 | single protein format |
| CHEMBL3774448 |  |
IC50 | = | 12.8 | nM | 272.35 | O=C1NC(=S)S/C1=C\c1ccc2ncccc2c1 | Homo sapiens | CHEMBL3778422 | single protein format |
| CHEMBL4436188 |  |
IC50 | = | 15.0 | nM | 566.63 | C[C@H](c1ccnc(Nc2nc3ccc(-c4cnn(CC5CCC5)c4)cc3[nH]2)c1)N1CCN(C(=O)CC(F)(F)F)CC1 | Homo sapiens | CHEMBL4380526 | assay format |
| CHEMBL5191892 |  |
IC50 | = | 15.0 | nM | 444.5 | C[C@H](NC(=O)c1ccc2cc1OCCOCCNc1ccn3ncc-2c3n1)c1ccncc1 | Homo sapiens | CHEMBL5167578 | assay format |
| CHEMBL3799389 |  |
IC50 | = | 21.0 | nM | 360.37 | O=C1Nc2ccc(NC(=O)C3CC3)cc2/C1=C1/Nc2ccccc2/C1=N\O | Homo sapiens | CHEMBL3802095 | single protein format |
| CHEMBL3799505 |  |
IC50 | = | 24.0 | nM | 390.44 | CC(C)(C)CC(=O)Nc1ccc2c(c1)/C(=C1/Nc3ccccc3/C1=N\O)C(=O)N2 | Homo sapiens | CHEMBL3802095 | single protein format |
| CHEMBL3798563 |  |
IC50 | = | 24.0 | nM | 486.4 | O=C1Nc2ccc(NC(=O)c3cc([N+](=O)[O-])cc([N+](=O)[O-])c3)cc2/C1=C1/Nc2ccccc2/C1=N\O | Homo sapiens | CHEMBL3802095 | single protein format |
| CHEMBL4594167 |  |
IC50 | = | 25.0 | nM | 525.54 | CNc1cc(-c2ccc3nc(Nc4cc(CN5CCN(C(=O)CC(F)(F)F)CC5)ccn4)[nH]c3c2)ncn1 | Homo sapiens | CHEMBL4380526 | assay format |
| CHEMBL4566796 |  |
IC50 | = | 30.0 | nM | 554.58 | COCc1cc(-c2ccc3nc(Nc4cc([C@@H](C)N5CCN(C(=O)CC(F)(F)F)CC5)ccn4)[nH]c3c2)ncn1 | Homo sapiens | CHEMBL4380526 | assay format |
| CHEMBL388978 |  |
IC50 | = | 30.4 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328389 | single protein format |
| CHEMBL5193635 |  |
IC50 | = | 31.0 | nM | 443.51 | CC(NC(=O)c1ccc2cc1OCCOCCNc1ccn3ncc-2c3n1)c1ccccc1 | Homo sapiens | CHEMBL5167578 | assay format |
| CHEMBL513703 |  |
IC50 | = | 32.0 | nM | 376.42 | CC(C)(C)C(=O)Nc1ccc2c(c1)/C(=C1/Nc3ccccc3/C1=N\O)C(=O)N2 | Homo sapiens | CHEMBL3802095 | single protein format |
| CHEMBL3605057 |  |
IC50 | = | 43.2 | nM | 464.61 | O=C(NCCCNc1nc(Nc2cccc(CN3CCOCC3)c2)ncc1C1CC1)C1CCC1 | Homo sapiens | CHEMBL5046586 | cell-based format |
| CHEMBL5087558 |  |
IC50 | = | 49.0 | nM | 395.46 | CC(C)(C)NC(=O)c1ccc2cc1OCCOCCNc1ccn3ncc-2c3n1 | Homo sapiens | CHEMBL5167578 | assay format |
| CHEMBL3797480 |  |
IC50 | = | 51.0 | nM | 376.42 | CCCCC(=O)Nc1ccc2c(c1)/C(=C1/Nc3ccccc3/C1=N\O)C(=O)N2 | Homo sapiens | CHEMBL3802095 | single protein format |
| CHEMBL5090046 |  |
IC50 | = | 58.2 | nM | 477.61 | O=C(NCCCNc1nc(Nc2cccc(NC(=O)N3CCCC3)c2)ncc1C1CC1)C1CCC1 | Homo sapiens | CHEMBL5046586 | cell-based format |
| CHEMBL1231206 |  |
IC50 | = | 71.0 | nM | 374.47 | Cc1ccc(-c2ccc3c(ccc4sc5c(c43)NC[C@@H](C)NC5=O)n2)cn1 | Homo sapiens | CHEMBL5212748 | single protein format |
| CHEMBL5433785 |  |
IC50 | = | 100.0 | nM | 414.49 | COc1cnc(Nc2ccc(CS(C)(=O)=O)cc2)nc1Nc1cc(C2CC2)[nH]n1 | Homo sapiens | CHEMBL5318943 | single protein format |