Q9UDY8 | MALT1_HUMAN | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00656 | Peptidase_C14 - Caspase domain | 343~556 | |
| PF13895 | Ig_2 - Immunoglobulin domain | 230~307 | |
| PF13927 | Ig_3 - Immunoglobulin domain | 128~194 | |
| PF18703 | MALT1_Ig - MALT1 Ig-like domain | 583~719 |
3D structures mapped by conservation among orthologs
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set_4 ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // EUF07710 ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set_2 ]
[ Domain: "DEATH domain" // Death ]
[ Domain: "Caspase-like" // Peptidase_C14 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3806155 |  |
IC50 | = | 0.023 | nM | 481.83 | CO[C@@H](C)c1c(NC(=O)Nc2cnc(-n3nccn3)c(C(F)(F)F)c2)cnc2cc(Cl)nn12 | Homo sapiens | CHEMBL3807231 | cell-based format |
| CHEMBL3805390 |  |
IC50 | = | 0.028 | nM | 488.34 | COCC(c1c(NC(=O)Nc2cnc(-n3nccn3)c(Cl)c2)cnc2cc(Cl)nn12)C1CC1 | Homo sapiens | CHEMBL3807231 | cell-based format |
| CHEMBL3806279 |  |
IC50 | = | 0.052 | nM | 394.36 | CO[C@@H](C)c1c(NC(=O)Nc2cncc(C(F)(F)F)c2)cnc2cc(C)nn12 | Homo sapiens | CHEMBL3807231 | cell-based format |
| CHEMBL3806235 |  |
IC50 | = | 0.094 | nM | 493.84 | O=C(Nc1cnc(-n2nccn2)c(C(F)(F)F)c1)Nc1cnc2cc(Cl)nn2c1C1CCCO1 | Homo sapiens | CHEMBL3807231 | cell-based format |
| CHEMBL3806299 |  |
IC50 | = | 0.134 | nM | 459.34 | CC(C)c1c(NC(=O)Nc2ccc(-n3cc(CN)cn3)c(Cl)c2)cnc2cc(Cl)nn12 | Homo sapiens | CHEMBL3807231 | cell-based format |
| CHEMBL3805576 |  |
IC50 | = | 0.248 | nM | 517.92 | CC(C)c1c(NC(=O)Nc2cnc(N3CCCS3(=O)=O)c(C(F)(F)F)c2)cnc2cc(Cl)nn12 | Homo sapiens | CHEMBL3807231 | cell-based format |
| CHEMBL4784740 |  |
IC50 | = | 2.0 | nM | 440.29 | O=C(Nc1cnc(-n2nccn2)c(Cl)c1)Nc1cnc2ccc(Cl)cc2c1C1CC1 | Homo sapiens | CHEMBL4667669 | single protein format |
| CHEMBL4781879 |  |
IC50 | = | 3.0 | nM | 462.3 | COC[C@H](C)c1c(NC(=O)Nc2cnc(-n3nccn3)c(Cl)c2)cnc2cc(Cl)nn12 | Homo sapiens | CHEMBL4705922 | single protein format |
| CHEMBL4745946 |  |
IC50 | = | 3.0 | nM | 432.28 | CC(C)c1c(NC(=O)Nc2cnc(-n3nccn3)c(Cl)c2)cnc2cc(Cl)nn12 | Homo sapiens | CHEMBL4705922 | single protein format |
| CHEMBL4128769 |  |
IC50 | = | 4.0 | nM | 418.29 | O=C(Nc1cnc(-n2nccn2)c(Cl)c1)C1CCN(c2ncccc2Cl)CC1 | Homo sapiens | CHEMBL4122924 | single protein format |
| CHEMBL4760571 |  |
IC50 | = | 4.0 | nM | 462.3 | COC[C@@H](C)c1c(NC(=O)Nc2cnc(-n3nccn3)c(Cl)c2)cnc2cc(Cl)nn12 | Homo sapiens | CHEMBL4705922 | single protein format |
| CHEMBL4746044 |  |
IC50 | = | 4.0 | nM | 414.78 | CO[C@@H](C)c1c(NC(=O)Nc2ccnc(C(F)(F)F)c2)cnc2cc(Cl)nn12 | Homo sapiens | CHEMBL4705922 | single protein format |
| CHEMBL5078790 |  |
IC50 | = | 5.0 | nM | 478.34 | CO[C@@H](C)c1c(NC(=O)Nc2cnc(C(=O)N3CCCC3)c(Cl)c2)cnc2cc(Cl)nn12 | Homo sapiens | CHEMBL5033381 | single protein format |
| CHEMBL4786953 |  |
IC50 | = | 5.0 | nM | 430.26 | O=C(Nc1cnc(-n2nccn2)c(Cl)c1)Nc1cnc2cc(Cl)nn2c1C1CC1 | Homo sapiens | CHEMBL4705922 | single protein format |
| CHEMBL4748253 |  |
IC50 | = | 6.0 | nM | 448.27 | CO[C@@H](C)c1c(NC(=O)Nc2cnc(-n3nccn3)c(Cl)c2)cnc2cc(Cl)nn12 | Homo sapiens | CHEMBL4667669 | single protein format |
| CHEMBL4741853 |  |
IC50 | = | 6.0 | nM | 423.84 | O=C(Nc1cnc(-n2nccn2)c(Cl)c1)Nc1cnc2ccc(F)cc2c1C1CC1 | Homo sapiens | CHEMBL4667669 | single protein format |
| CHEMBL4762086 |  |
IC50 | = | 7.0 | nM | 405.85 | O=C(Nc1cnc(-n2nccn2)c(Cl)c1)Nc1cnc2ccccc2c1C1CC1 | Homo sapiens | CHEMBL4667669 | single protein format |
| CHEMBL4779581 |  |
IC50 | = | 7.0 | nM | 427.83 | CC(O)c1c(NC(=O)Nc2cnc(-n3nccn3)c(Cl)c2)cnc2ccc(F)cc12 | Homo sapiens | CHEMBL4667669 | single protein format |
| CHEMBL4128888 |  |
IC50 | = | 7.0 | nM | 398.86 | Nc1cccnc1N1CCC(C(=O)Nc2cnc(-n3nccn3)c(Cl)c2)CC1 | Homo sapiens | CHEMBL4122924 | single protein format |
| CHEMBL4763128 |  |
IC50 | = | 10.0 | nM | 474.31 | O=C(Nc1cnc(-n2nccn2)c(Cl)c1)Nc1cnc2cc(Cl)nn2c1C1CCOCC1 | Homo sapiens | CHEMBL4705922 | single protein format |