Q9UBX1 | CATF_HUMAN | Cathepsin F (CTSF)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00112 | Peptidase_C1 - Papain family cysteine protease | 272~481 | |
| PF08246 | Inhibitor_I29 - Cathepsin propeptide inhibitor domain (I29) | 187~244 |
3D structures mapped by conservation among orthologs
[ Domain: "Cysteine proteinases" // Peptidase_C1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL399361 |  |
IC50 | = | 0.3 | nM | 571.67 | CC(C)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)N[C@H](C#N)Cc1ccccc1 | Homo sapiens | CHEMBL1290878 | cell-based format |
| CHEMBL1289660 |  |
IC50 | = | 12.0 | nM | 590.64 | CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)N[C@H](C#N)Cc1ccncc1 | Homo sapiens | CHEMBL1290878 | cell-based format |
| CHEMBL1289764 |  |
IC50 | = | 24.0 | nM | 501.53 | CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2cn[nH]c2)cc1)C(F)(F)F)C(=O)N[C@H](C#N)Cc1ccccc1 | Homo sapiens | CHEMBL1290878 | cell-based format |
| CHEMBL1288525 |  |
IC50 | = | 37.0 | nM | 594.65 | CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(C3(C(N)=O)CC3)cc2)cc1)C(F)(F)F)C(=O)N[C@H](C#N)Cc1ccccc1 | Homo sapiens | CHEMBL1290878 | cell-based format |
| CHEMBL1288528 |  |
IC50 | = | 51.0 | nM | 588.65 | CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(-c3ccncc3)cc2)cc1)C(F)(F)F)C(=O)N[C@H](C#N)Cc1ccccc1 | Homo sapiens | CHEMBL1290878 | cell-based format |
| CHEMBL1288527 |  |
IC50 | = | 64.0 | nM | 591.6 | CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc([C@@H](O)C(F)F)cc2)cc1)C(F)(F)F)C(=O)N[C@H](C#N)Cc1ccccc1 | Homo sapiens | CHEMBL1290878 | cell-based format |
| CHEMBL1289440 |  |
IC50 | = | 67.0 | nM | 589.66 | CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)N[C@H](C#N)Cc1ccccc1 | Homo sapiens | CHEMBL1290878 | cell-based format |
| CHEMBL3427166 |  |
IC50 | = | 74.0 | nM | 507.54 | CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(O)S(=O)(=O)[O-].[Na+] | Homo sapiens | CHEMBL5106613 | single protein format |
| CHEMBL1290303 |  |
IC50 | = | 80.0 | nM | 555.62 | CS(=O)(=O)c1ccc(-c2ccc([C@H](N[C@H](C(=O)N[C@H](C#N)Cc3ccccc3)C3CC3)C(F)(F)F)cc2)cc1 | Homo sapiens | CHEMBL1290878 | cell-based format |
| CHEMBL1289988 |  |
IC50 | = | 147.0 | nM | 569.65 | CS(=O)(=O)c1ccc(-c2ccc([C@H](N[C@@H](CC3CC3)C(=O)N[C@H](C#N)Cc3ccccc3)C(F)(F)F)cc2)cc1 | Homo sapiens | CHEMBL1290878 | cell-based format |
| CHEMBL1290191 |  |
IC50 | = | 174.0 | nM | 557.64 | CC(C)[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)N[C@H](C#N)Cc1ccccc1 | Homo sapiens | CHEMBL1290878 | cell-based format |
| CHEMBL390474 |  |
IC50 | = | 331.0 | nM | 247.29 | Cc1cccc(O[C@H]2CCN3C[C@H]2OC3=O)c1C | Homo sapiens | CHEMBL907577 | single protein format |
| CHEMBL230474 |  |
IC50 | = | 487.0 | nM | 219.24 | O=C1O[C@@H]2CN1CC[C@@H]2Oc1ccccc1 | Homo sapiens | CHEMBL907577 | single protein format |
| CHEMBL1289441 |  |
IC50 | = | 547.0 | nM | 499.53 | CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)NCC#N | Homo sapiens | CHEMBL1290878 | cell-based format |
| CHEMBL1289553 |  |
IC50 | = | 654.0 | nM | 581.55 | CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)N[C@H](C#N)CC(F)(F)F | Homo sapiens | CHEMBL1290878 | cell-based format |
| CHEMBL481611 |  |
IC50 | = | 795.0 | nM | 525.57 | CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)NC1(C#N)CC1 | Homo sapiens | CHEMBL945083 | single protein format |
| CHEMBL2153161 |  |
Ki | = | 21.0 | nM | 380.47 | CC(C)CS(=O)(=O)C[C@H](NC(=O)c1ccccc1)C(=O)N(C)N(C)C#N | Homo sapiens | CHEMBL2156365 | single protein format |