Q9UBN7 | HDAC6_HUMAN | Histone deacetylase 6 (HDAC6)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00850 | Hist_deacetyl - Histone deacetylase domain | 106~401 | |
| PF00850 | Hist_deacetyl - Histone deacetylase domain | 500~797 | |
| PF02148 | zf-UBP - Zn-finger in ubiquitin-hydrolases and other protein | 1133~1194 |
3D structures mapped by conservation among orthologs
[ Domain: "Arginase/deacetylase" // Hist_deacetyl ]
[ Domain: "RING/U-box" // zf-UBP ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4876454 |  |
IC50 | = | 0.002 | nM | 446.5 | CC(C)(C)OC(=O)Nc1ccc(-c2cc(NC(=O)CCCCCCC(=O)NO)no2)cc1 | Homo sapiens | CHEMBL4842905 | single protein format |
| CHEMBL511749 |  |
IC50 | = | 0.002 | nM | 446.5 | CC(C)(C)OC(=O)Nc1ccc(-c2cc(C(=O)NCCCCCCC(=O)NO)no2)cc1 | Homo sapiens | CHEMBL976445 | single protein format |
| CHEMBL469274 |  |
IC50 | < | 0.002 | nM | 446.5 | CC(C)(C)OC(=O)Nc1cccc(-c2cc(C(=O)NCCCCCCC(=O)NO)no2)c1 | Homo sapiens | CHEMBL976445 | single protein format |
| CHEMBL5198547 |  |
IC50 | = | 0.0095 | nM | 335.45 | CCN(CC)c1ccc(C(=O)NCCCCCCC(=O)NO)cc1 | Homo sapiens | CHEMBL5152095 | single protein format |
| CHEMBL4290831 |  |
IC50 | = | 0.1 | nM | 527.03 | CC(=O)Nc1ccc(-c2ccnc(Nc3ccc(NC(=O)CCCCCCC(=O)NO)cc3)n2)cc1.Cl | Homo sapiens | CHEMBL4268223 | single protein format |
| CHEMBL5195946 |  |
IC50 | = | 0.1 | nM | 376.37 | COc1ccc2c3c(cccc13)C(=O)N(Cc1ccc(C(=O)NO)cc1)C2=O | Homo sapiens | CHEMBL5096839 | single protein format |
| CHEMBL4098975 |  |
IC50 | = | 0.14 | nM | 504.6 | O=C(CCCCCCC(=O)Nc1ccc(NCCCn2cc(-c3ncnc4[nH]ccc34)cn2)cc1)NO | Homo sapiens | CHEMBL4031304 | cell-based format |
| CHEMBL4550526 |  |
IC50 | < | 0.17 | nM | 448.55 | CC(C)(C)OC(=O)Nc1cccc(-c2csc(NC(=O)CCCCCC(=O)NO)n2)c1 | Homo sapiens | CHEMBL4401311 | single protein format |
| CHEMBL3912061 |  |
IC50 | = | 0.17 | nM | 387.46 | CS(=O)(=O)NCCc1cn(Cc2ccc(C(=O)NO)cc2)c2ccccc12 | Homo sapiens | CHEMBL3888198 | single protein format |
| CHEMBL2417782 |  |
IC50 | < | 0.2 | nM | 462.57 | CC(C)(C)OC(=O)Nc1cccc(-c2csc(NC(=O)CCCCCCC(=O)NO)n2)c1 | Homo sapiens | CHEMBL2424285 | cell-based format |
| CHEMBL4243347 |  |
IC50 | = | 0.2 | nM | 462.51 | O=C(CCCCCCC(=O)Nc1ccc(Nc2nc(-c3cn[nH]c3)c3cc[nH]c3n2)cc1)NO | Homo sapiens | CHEMBL4233425 | single protein format |
| CHEMBL4247128 |  |
IC50 | = | 0.25 | nM | 516.61 | C=CCCn1cc(-c2nc(Nc3ccc(NC(=O)CCCCCCC(=O)NO)cc3)nc3[nH]ccc23)cn1 | Homo sapiens | CHEMBL4233425 | single protein format |
| CHEMBL4748025 |  |
IC50 | = | 0.275 | nM | 301.32 | O=C(NO)c1cnc(N[C@H](c2ccccc2)C2CC2)c(F)c1 | Homo sapiens | CHEMBL4715300 | single protein format |
| CHEMBL4104117 |  |
IC50 | = | 0.291 | nM | 293.33 | O=C(NO)c1ccc(CNc2cccc3cccnc23)cc1 | Homo sapiens | CHEMBL4028190 | cell-based format |
| CHEMBL4863515 |  |
IC50 | = | 0.3 | nM | 348.41 | O=C(NO)c1ccc(CN2CCCc3cc(-c4cc[nH]n4)ccc32)cc1 | Homo sapiens | CHEMBL4823888 | single protein format |
| CHEMBL3621294 |  |
IC50 | = | 0.323 | nM | 396.45 | O=C(CCCCCCC(=O)Nc1ccc2c(c1)/C(=C/c1ccc[nH]1)C(=O)N2)NO | Homo sapiens | CHEMBL3626713 | single protein format |
| CHEMBL4126811 |  |
IC50 | = | 0.33 | nM | 452.47 | CC(C)(C)OC(=O)Nc1ccc(-c2cc(C(=O)NCc3ccc(C(=O)NO)cc3)no2)cc1 | Homo sapiens | CHEMBL4355674 | cell-based format |
| CHEMBL4756236 |  |
IC50 | = | 0.351 | nM | 302.31 | O=C(NO)c1cnc(N[C@@H](c2ccccn2)C2CC2)c(F)c1 | Homo sapiens | CHEMBL4715300 | single protein format |
| CHEMBL5188297 |  |
IC50 | = | 0.4 | nM | 460.54 | O=C(CCCCCCC(=O)N/N=C/c1cnc(N(c2ccccc2)c2ccccc2)nc1)NO | Homo sapiens | CHEMBL5096791 | single protein format |
| CHEMBL4777296 |  |
IC50 | = | 0.4 | nM | 386.45 | NCc1ccc(NC(=O)N(CCCCO)Cc2ccc(C(=O)NO)cc2)cc1 | Homo sapiens | CHEMBL4729568 | cell-based format |